O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation

(2016) H J Lee et al.   Cell Death & Disease

High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation

(2015) Sujith Dassanayaka et al.   BIOCHEMICAL JOURNAL

Post-translationally-modified structures in the autophagy machinery: an integrative perspective

(2015) Hana Popelka et al.   FEBS Journal

O-GlcNAcomic Profiling Identifies WidespreadO-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

(2015) Junfeng Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A little sugar goes a long way: The cell biology of O-GlcNAc

(2015) Michelle R. Bond et al.   JOURNAL OF CELL BIOLOGY

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer

(2015) V. L. Sodi et al.   MOLECULAR CANCER RESEARCH

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

(2015) Nicholas P. Marotta et al.   Nature Chemistry

Diabetes-associated dysregulation ofO-GlcNAcylation in rat cardiac mitochondria

(2015) Partha S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches

(2015) Jianhua Zhang   Redox Biology

O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling

(2015) Jianhua Shi et al.   Scientific Reports

The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells

(2014) Michaël Boyer-Guittaut et al.   Autophagy

Inhibition of mTOR affects protein stability of OGT

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Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

(2014) Stéphan Hardivillé et al.   Cell Metabolism

DecreasedO-Linked GlcNAcylation Protects from Cytotoxicity Mediated by Huntingtin Exon1 Protein Fragment

(2014) Amit Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ProteinO-GlcNAcylation and Cardiovascular (Patho)physiology

(2014) Susan A. Marsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioenergetic adaptation in response to autophagy regulators during rotenone exposure

(2014) Samantha Giordano et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of autophagy by protein post-translational modification

(2014) Willayat Yousuf Wani et al.   LABORATORY INVESTIGATION

O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation

(2014) Bin Guo et al.   NATURE CELL BIOLOGY

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

Three Decades of Research on O-GlcNAcylation – A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism

(2014) Gerald W. Hart   Frontiers in Endocrinology

O-GlcNAcase Expression is Sensitive to Changes in O-GlcNAc Homeostasis

(2014) Zhen Zhang et al.   Frontiers in Endocrinology

Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells

(2013) Tanecia Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells

(2013) Matthew Dodson et al.   Autophagy

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons

(2013) Gloria A. Benavides et al.   FREE RADICAL BIOLOGY AND MEDICINE

Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells

(2013) Donna Crabtree et al.   JOURNAL OF NEUROCHEMISTRY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

(2013) Peter Borghgraef et al.   PLoS One

Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart

(2012) Susan A. Marsh et al.   LIFE SCIENCES

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases

(2012) P. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

(2012) J. F. Alfaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Assessing bioenergetic function in response to oxidative stress by metabolic profiling

(2011) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inhibition of lysosomal functions reduces proteasomal activity

(2009) Liyan Qiao et al.   NEUROSCIENCE LETTERS

Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats

(2008) Norbert Fülöp et al.   BIOGERONTOLOGY

Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose

(2008) Yong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain

Cytosolic O-glycosylation is abundant in nerve terminals

(2003) Robert N. Cole et al.   JOURNAL OF NEUROCHEMISTRY