Regulation of autophagy by protein post-translational modification

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

DecreasedO-Linked GlcNAcylation Protects from Cytotoxicity Mediated by Huntingtin Exon1 Protein Fragment

(2014) Amit Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

(2014) Nicol Birsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress

(2014) Rafah Mackeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between Two Essential Nutrient-sensitive Enzymes

(2014) John W. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy

(2014) Batool Ossareh-Nazari et al.   JOURNAL OF CELL BIOLOGY

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

LC3B-II deacetylation by histone deacetylase 6 is involved in serum-starvation-induced autophagic degradation

(2013) Kun-Peng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria

(2013) Melissa K. McCoy et al.   HUMAN MOLECULAR GENETICS

TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy

(2013) K. Shirahama-Noda et al.   JOURNAL OF CELL SCIENCE

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

(2013) Min Fu et al.   MOLECULAR BIOLOGY OF THE CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation

(2013) K. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy

(2013) T. Tasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage

(2013) Martina Wirth et al.   SEMINARS IN CANCER BIOLOGY

Emerging roles of E3 ubiquitin ligases in autophagy

(2013) Ersheng Kuang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

(2012) Yong Ryoul Yang et al.   AGING CELL

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins

(2012) David Colecchia et al.   Autophagy

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

(2012) Kei Okatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAc Modification Prevents Peptide-Dependent Acceleration of α-Synuclein Aggregation

(2012) Nicholas P. Marotta et al.   CHEMBIOCHEM

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart

(2012) Susan A. Marsh et al.   LIFE SCIENCES

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling

(2012) Shuai Wang et al.   PLoS One

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

(2012) Yang Yu et al.   PLoS One

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain

(2012) Ying Liu et al.   PLoS One

O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases

(2012) P. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection

(2012) Ersheng Kuang et al.   PLoS Genetics

ULK1, Mammalian Target of Rapamycin, and Mitochondria: Linking Nutrient Availability and Autophagy

(2011) Mondira Kundu   ANTIOXIDANTS & REDOX SIGNALING

Redox-Based Regulation of Apoptosis: S-Glutathionylation As a Regulatory Mechanism to Control Cell Death

(2011) Vikas Anathy et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

(2011) Harald W. Platta et al.   BIOCHEMICAL JOURNAL

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function

(2011) Victor M. Darley-Usmar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

RNF185, a Novel Mitochondrial Ubiquitin E3 Ligase, Regulates Autophagy through Interaction with BNIP1

(2011) Fei Tang et al.   PLoS One

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Protein kinase C inhibits autophagy and phosphorylates LC3

(2010) Houbo Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

(2010) Y.-Y. Park et al.   JOURNAL OF CELL SCIENCE

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL

(2009) Einat Zalckvar et al.   Autophagy

Characterization of the Atg17–Atg29–Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae

(2009) Yukiko Kabeya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats

(2008) Norbert Fülöp et al.   BIOGERONTOLOGY

Self-Interaction Is Critical for Atg9 Transport and Function at the Phagophore Assembly Site during Autophagy

(2008) Congcong He et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA