Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

(2017) Adam H. Courtney et al.   MOLECULAR CELL

Optical control of cell signaling by single-chain photoswitchable kinases

(2017) Xin X. Zhou et al.   SCIENCE

Engineering extrinsic disorder to control protein activity in living cells

(2016) Onur Dagliyan et al.   SCIENCE

Expanding and Reprogramming the Genetic Code of Cells and Animals

(2014) Jason W. Chin   Annual Review of Biochemistry

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1

(2014) Wolfgang H. Schmied et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vitro membrane reconstitution of the T-cell receptor proximal signaling network

(2014) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells

(2013) Fatima Talab et al.   MOLECULAR CANCER RESEARCH

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

(2013) A. Stirnweiss et al.   Science Signaling

Disentangling nestedness from models of ecological complexity

(2012) Alex James et al.   NATURE

Conformational states of the kinase Lck regulate clustering in early T cell signaling

(2012) Jérémie Rossy et al.   NATURE IMMUNOLOGY

Wnt Signalling Pathway Parameters for Mammalian Cells

(2012) Chin Wee Tan et al.   PLoS One

The T Cell Receptor Triggering Apparatus Is Composed of Monovalent or Monomeric Proteins

(2011) John R. James et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells

(2011) Arnaud Gautier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

Genetically Encoded Photocontrol of Protein Localization in Mammalian Cells

(2010) Arnaud Gautier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered allosteric activation of kinases in living cells

(2010) Andrei V Karginov et al.   NATURE BIOTECHNOLOGY

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

(2010) M. N. Artyomov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45

(2009) A.E. Saunders et al.   CELLULAR SIGNALLING

Genetically Encoded Forster Resonance Energy Transfer Sensors for the Conformation of the Src Family Kinase Lck

(2009) W. Paster et al.   JOURNAL OF IMMUNOLOGY