Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
出版年份 2017 全文链接
标题
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
作者
关键词
-
出版物
Nature Communications
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-12-01
DOI
10.1038/s41467-017-01489-1
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- HTS-compatible FRET-based conformational sensors clarify membrane receptor activation
- (2017) Pauline Scholler et al. Nature Chemical Biology
- Opportunities for therapeutic antibodies directed at G-protein-coupled receptors
- (2017) Catherine J. Hutchings et al. NATURE REVIEWS DRUG DISCOVERY
- Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
- (2017) David Moreno Delgado et al. eLife
- Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
- (2016) Dean P. Staus et al. NATURE
- Organization and functions of mGlu and GABAB receptor complexes
- (2016) Jean-Philippe Pin et al. NATURE
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex
- (2016) Nikhil J. Pandya et al. PROTEOMICS
- Multicolor time-resolved Förster resonance energy transfer microscopy reveals the impact of GPCR oligomerization on internalization processes
- (2015) Orestis Faklaris et al. FASEB JOURNAL
- Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
- (2015) James A. Monn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS
- (2014) S. Yin et al. JOURNAL OF NEUROSCIENCE
- Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
- (2014) Li Xue et al. Nature Chemical Biology
- GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics
- (2014) Azra Mujić-Delić et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Conformational biosensors reveal GPCR signalling from endosomes
- (2013) Roshanak Irannejad et al. NATURE
- Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
- (2013) E. Doumazane et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs
- (2012) Peter J. Flor et al. BIOCHEMICAL PHARMACOLOGY
- Opportunities for functional selectivity in GPCR antibodies
- (2012) David R. Webb et al. BIOCHEMICAL PHARMACOLOGY
- Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging
- (2012) Tengfei Li et al. FASEB JOURNAL
- CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography
- (2012) Rebecca A. Wright et al. NEUROPHARMACOLOGY
- Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling
- (2012) D. El Moustaine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nanobody stabilization of G protein-coupled receptor conformational states
- (2011) Jan Steyaert et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Accelerating Protein Docking in ZDOCK Using an Advanced 3D Convolution Library
- (2011) Brian G. Pierce et al. PLoS One
- A highly selective agonist for the metabotropic glutamate receptor mGluR2
- (2011) Simon D. Nielsen et al. MedChemComm
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
- (2010) Colleen M. Niswender et al. Annual Review of Pharmacology and Toxicology
- A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
- (2010) Etienne Doumazane et al. FASEB JOURNAL
- Therapeutic antibodies directed at G protein-coupled receptors
- (2010) Catherine J. Hutchings et al. mAbs
- Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation
- (2010) Francesca Fallarino et al. NATURE MEDICINE
- The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors
- (2010) Philippe Rondard et al. NEUROPHARMACOLOGY
- Metabotropic glutamate receptors: From the workbench to the bedside
- (2010) F. Nicoletti et al. NEUROPHARMACOLOGY
- CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
- (2010) S. Jahnichen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Jalview Version 2--a multiple sequence alignment editor and analysis workbench
- (2009) A. M. Waterhouse et al. BIOINFORMATICS
- Therapeutic antibodies: successes, limitations and hopes for the future
- (2009) Patrick Chames et al. BRITISH JOURNAL OF PHARMACOLOGY
- Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen
- (2009) Ghislaine Behar et al. FEBS Journal
- Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation
- (2009) S. Daumas et al. LEARNING & MEMORY
- Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers
- (2009) T. Moore-Morris et al. MOLECULAR PHARMACOLOGY
- Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
- (2008) Damien Maurel et al. NATURE METHODS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started