Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
出版年份 2016 全文链接
标题
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
作者
关键词
-
出版物
NATURE
Volume 535, Issue 7612, Pages 448-452
出版商
Springer Nature
发表日期
2016-07-12
DOI
10.1038/nature18636
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling
- (2015) Aashish Manglik et al. CELL
- Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)
- (2014) Ryan T. Strachan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tracing an allosteric pathway regulating the activity of the HslV protease
- (2014) Lichi Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling
- (2014) H. Ongun Onaran et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- Ligands Raise the Constraint That Limits Constitutive Activation in G Protein-coupled Opioid Receptors
- (2013) Vanessa Vezzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
- (2013) Aaron M. Ring et al. NATURE
- A three-stage biophysical screening cascade for fragment-based drug discovery
- (2013) Ellene H Mashalidis et al. Nature Protocols
- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
- (2012) Yutaka Kofuku et al. Nature Communications
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Multiple ligand-specific conformations of the β2-adrenergic receptor
- (2011) Alem W Kahsai et al. Nature Chemical Biology
- Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor
- (2011) R. Moukhametzianov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Allosteric Coupling and Conformational Fluctuations in Proteins
- (2009) H. Onaran et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Identification of two distinct inactive conformations of the 2-adrenergic receptor reconciles structural and biochemical observations
- (2009) R. O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started