Article
Biochemistry & Molecular Biology
Ssu-Yu Chen, Yung-Lung Chang, Shu-Ting Liu, Gunng-Shinng Chen, Shiao-Pieng Lee, Shih-Ming Huang
Summary: DSF-Cu+/Cu2+ complex induces cytotoxicity in oral epidermoid carcinoma cells but not in human gingival epithelial cells. It affects cell cycle, cell proliferation, and ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Meixu Chen, Zeqian Huang, Meng Xia, Yaqing Ding, Ting Shan, Zilin Guan, Xiuling Dai, Xiaoyu Xu, Yanjuan Huang, Min Huang, Chunshun Zhao
Summary: The FDA-approved drug Disulfiram has been found to have potent antitumor therapeutic effect by generating Cu(DTC)2, but its poor tumor selectivity and lack of sufficient endogenous Cu2+ concentration within the tumor site hinder its application. A GSH-responsive coordination nanoparticles (Cu-IXZ@DSF) was established to achieve selective triggered tumor in situ Cu(DTC)2 generation for antitumor therapy, showing good biosafety and excellent antitumor effect via endoplasmic reticulum stress (ERS) and reactive oxygen species (ROS) generation pathway. This nanocarrier provides a specific-triggered antitumor Cu(DTC)2 generation for DSF-based chemotherapy with high therapeutic effect and biosafety, showing great potential of treating cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Sheila S. Fontes, Mateus L. Nogueira, Rosane B. Dias, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Marcos A. Vannier-Santos, Daniel P. Bezerra
Summary: This study investigated the combination of curcumin and disulfiram in the treatment of melanoma and found synergistic anti-tumor effects. The combination promoted apoptosis and DNA fragmentation in melanoma cells and increased oxidative stress. In animal experiments, the combination therapy inhibited tumor growth.
Article
Engineering, Biomedical
Jie Chen, Xiaomin Tan, Yanjuan Huang, Congjun Xu, Zishan Zeng, Ting Shan, Zilin Guan, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao
Summary: In this study, a reactive oxygen species-activatable self-amplifying prodrug nanoagent was developed for the tumor-specific dual-activation of chemotherapy and photodynamic therapy. The results showed a significant tumor-killing effect with little systemic toxicity.
Article
Chemistry, Multidisciplinary
Jiaojiao Xu, Binbin Zheng, Sihang Zhang, Xueling Liao, Qinli Tong, Guoguang Wei, Sheng Yu, Gaoxian Chen, Aihua Wu, Shuai Gao, Yuyi Qian, Zeyu Xiao, Wei Lu
Summary: The study presents a novel adoptive macrophage therapy using copper sulfide nanoparticles to induce ROS production and inhibit tumor growth, improve the tumor microenvironment, elicit systemic antitumor immunity, thus prolonging the survival time of tumor patients.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Medicinal
Iftekhar Hassan, Hossam Ebaid, Ibrahim M. Alhazza, Jameel Al-Tamimi, Ahmed M. Rady
Summary: The present study investigated the potential of combining the anticancer drug 5-FU with copper and its chelating agent, disulfiram, in treating hepatocellular carcinoma in rats. The combination treatment showed significant improvement in most parameters, improving histological details and triggering apoptosis in cancer cells to a remarkable extent. Manipulating copper levels greatly enhances the antineoplastic activity of 5-FU and sensitizes cancer cells to the increased efficacy of the drug.
Review
Chemistry, Medicinal
Peng Ji, Peng Wang, Hao Chen, Yajing Xu, Jianwen Ge, Zechong Tian, Zhirong Yan
Summary: Researchers have explored the potential value of metal elements in inducing cell death, with iron and copper particularly attracting attention. They can induce tumor cell death through different mechanisms, making them promising for cancer treatment.
Article
Biochemistry & Molecular Biology
Biao Xiang, Daowen Li, Yiqiang Chen, Meng Li, Yuan Zhang, Tun Sun, Shusheng Tang
Summary: The study demonstrated that curcumin has neuroprotective properties against copper-induced neurotoxicity and apoptosis. The potential mechanisms may involve the reduction of oxidative stress and mitochondrial apoptosis.
NEUROCHEMICAL RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Sen Lin, Dahao Wang, Chang Xu, Peng Zhang, Kai Gao, Chang Liu, Xifan Mei
Summary: In this study, folic acid modified celastrol-loaded nanoparticles were developed, which can release RA symptoms and have validated anti-inflammatory effects. These nanoparticles modify the polarization of macrophages and significantly reduce inflammation levels in serum and joints.
MATERIALS & DESIGN
(2022)
Article
Medicine, Research & Experimental
Lanlan Wang, Li Wang, Yang Zhang, Zhiyu Zhao, Cong Liu, Mengqi Li, Jiajing Liu, Shengyu Wang, Dong Yang, Fanghong Luo, Jianghua Yan
Summary: The newly identified photosensitizer LS-HB, derived from chlorin e6, was found to possess optimal spectral properties for photosensitization and excellent photostability. Photodynamic therapy with LS-HB demonstrated a potent dose-dependent phototoxic effect by generating excess reactive oxygen species in the mitochondria of tumor cells and subsequently inducing apoptosis. In vivo studies showed that LS-HB-PDT significantly inhibited the growth of melanoma.
MOLECULAR PHARMACEUTICS
(2022)
Article
Food Science & Technology
Pawan Kumar Raut, Hui Seong Lee, Sang Hoon Joo, Kyung-Soo Chun
Summary: Melanoma is a highly aggressive and treatment-resistant cancer, and a new study found that TQ can induce apoptosis in melanoma cells by hindering the Jak2/STAT3 signaling pathway through ROS generation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sukkum Ngullie Chang, Imran Khan, Chang Geon Kim, Seon Min Park, Dong Kyu Choi, Heejin Lee, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park
Summary: The study demonstrates the effectiveness of decursinol angelate (DA) in inhibiting melanoma cells and inducing autophagy and apoptosis, while blocking cell cycle progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Wei-Nan Zhao, Hongjuan Li, Shiguo Sun, Yongqian Xu
Summary: The nanotherapeutic approach GOx-CuCaP-DSF is designed to overcome challenges in chemodynamic therapy by self-supplying H2O2 and providing low valence metal ions. It enhances the efficiency of CDT through promoting the Cu+-based Fenton reaction and harnessing the therapeutic effect of a chemotherapeutic drug.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Dermatology
Joyce H. Park, Amanda Bienenfeld, Seth J. Orlow, Arielle R. Nagler
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2018)
Review
Dermatology
Thomas Stringer, Arielle Nagler, Seth J. Orlow, Vikash S. Oza
JOURNAL OF DERMATOLOGICAL TREATMENT
(2018)
Editorial Material
Dermatology
Oluwatobi A. Ogbechie-Godec, Jason F. Wang, Hao Feng, Seth J. Orlow
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Letter
Dermatology
Lauren E. Wiznia, Shields W. Callahan, David E. Cohen, Seth J. Orlow
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Article
Dermatology
Lauren E. Wiznia, Suneet Bhansali, Nooshin Brinster, Yasir M. Al-Qaqaa, Seth J. Orlow, Vikash Oza
PEDIATRIC DERMATOLOGY
(2019)
Article
Dermatology
Nekma Meah, Dmitri Wall, Katherine York, Bevin Bhoyrul, Laita Bokhari, Daniel Asz Sigall, Wilma F. Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Jeff Donovan, Samantha Eisman, Paul Farrant, Jack Green, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan D. Irvine, Satoshi Itami, Victoria Jolliffe, Brett King, Won-Soo Lee, Amy McMichael, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J. Orlow, Bianca Maria Piraccini, Adriana Rakowska, Pascal Reygagne, Janet L. Roberts, Lidia Rudnicka, Jerry Shapiro, Pooja Sharma, Antonella Tosti, Annika Vogt, Martin Wade, Leona Yip, Abraham Zlotogorski, Rodney Sinclair
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Article
Dermatology
Jorge Roman, Loren D. Krueger, Trevor K. Young, Evan A. Rieder, Lisa R. Rothman, Nikita Lakdawala, Arielle R. Nagler, Shane A. Meehan, Seth J. Orlow, Vikash S. Oza
Summary: This study identified a novel clinical phenotype called nasal papules, which are skin-colored dome-shaped papules concentrated on the nose and chin, potentially an under-recognized sequelae of acne disproportionately affecting adolescents with skin of color. Histopathologically, these lesions are indistinguishable from angiofibromas, indicating a need for further research and awareness of this condition.
PEDIATRIC DERMATOLOGY
(2021)
Article
Dermatology
Nekma Meah, Dmitri Wall, Katherine York, Bevin Bhoyrul, Laita Bokhari, Daniel Asz-Sigall, Wilma F. Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Jeff Donovan, Samantha Eisman, Paul Farrant, Jack Green, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan D. Irvine, Satoshi Itami, Victoria Jolliffe, Brett King, Won-Soo Lee, Amy McMichael, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J. Orlow, Bianca Maria Piraccini, Adriana Rakowska, Pascal Reygagne, Janet L. Roberts, Lidia Rudnicka, Jerry Shapiro, Pooja Sharma, Antonella Tosti, Annika Vogt, Martin Wade, Leona Yip, Abraham Zlotogorski, Rodney D. Sinclair
Summary: The international expert consensus on diagnosis and laboratory evaluation of alopecia areata revealed a high level of agreement in these aspects, while showing lower consensus in etiopathogenesis. This study highlights areas where future clinical research could focus to address unresolved hypotheses in patient care for alopecia areata.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Trevor K. Young, Katharina S. Shaw, Jinal K. Shah, Asif Noor, Risa A. Alperin, Adam J. Ratner, Seth J. Orlow, Rebecca A. Betensky, Gail F. Shust, Philip J. Kahn, Vikash S. Oza
Summary: During the peak of the COVID-19 pandemic in New York City in 2020, a study of 35 hospitalized children with suspected MIS-C found that 83% of them exhibited a variety of transient mucocutaneous symptoms including conjunctival injection, palmoplantar erythema, and lip hyperemia. These findings, occurring on average 2.7 days after the onset of fever, can be important clues for the recognition of MIS-C.
Article
Dermatology
Nkemjika Ugonabo, Elyse Love, Priscilla W. Wong, Evan A. Rieder, Seth J. Orlow, Randie H. Kim, Arielle R. Nagler
Summary: Acne patients prescribed isotretinoin were less likely to have psychiatric disorders and engage in suicidal behavior compared to the general population and acne patients prescribed antibiotics. The prevalence of suicidal behavior was lower during isotretinoin treatment than before or after treatment, highlighting the need for further exploration into the increase in suicidal behavior seen in isotretinoin patients one year after therapy.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Jason F. Wang, Trevor K. Young, Laura E. Melnick, Seth J. Orlow, Vikash S. Oza
Summary: The study found that most pediatric patients presenting to the emergency department for AD were either not prescribed a topical corticosteroid (TCS) or were prescribed a weak TCS, often over-the-counter. This may indicate a practice gap in AD management in the pediatric emergency department.
PEDIATRIC DERMATOLOGY
(2021)
Review
Dermatology
Dmitri Wall, Nekma Meah, Katherine York, Bevin Bhoyrul, Laita Bokhari, Leonardo Spagnol Abraham, Roisin Adams, Wilma Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Chel Campbell, Jen Chambers, Gang Chen, Vijaya Chitreddy, George Cotsarelis, Brittany Craiglow, Rachita Dhurat, Ncoza Dlova, Jeff Donovan, Bruna Duque-Estrada, Samantha Eisman, Abby Ellison, Paul Farrant, Juan Ferrando Barbera, Aida Gadzhigoroeva, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan D. Irvine, Victoria Jolliffe, Leslie Jones, Brett King, Won-Soo Lee, Nino Lortkipanidze, Amy McMichael, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J. Orlow, Yuliya Ovcharenko, Bianca Maria Piraccini, Rodrigo Pirmez, Adriana Rakowska, Pascal Reygagne, Melissa Riley, Lidia Rudnicka, David Saceda Corralo, Jerry Shapiro, Pooja Sharma, Tatiana Silyuk, Spartak Kaiumov, Desmond J. Tobin, Antonella Tosti, Sergio Vano-Galvan, Annika Vogt, Martin Wade, Leona Yip, Abraham Zlotogorski, Cheng Zhou, Rodney Sinclair
Summary: This study identified the domains and domain items needed to develop a global network of alopecia areata registries, which will facilitate a standardized approach for recording comprehensive, comparable data sets. This will enable oversight of new therapies introduction and utilization of real-world evidence, supporting the positive disruption in the alopecia areata treatment paradigm.
Article
Pharmacology & Pharmacy
Olga Lavinda, Prashiela Manga, Seth J. Orlow, Timothy Cardozo
Summary: The study demonstrates the importance of the TYR-TYRP1-TYRP2 complex in melanogenesis, suggesting that the formation of this complex may help stabilize the TYR protein and influence melanin production.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Dermatology
Christine C. Akoh, Seth J. Orlow
JOURNAL OF DRUGS IN DERMATOLOGY
(2020)
Review
Dermatology
Thomas Stringer, Julia K. Gittler, Seth J. Orlow