The histone deacetylase SIRT2 stabilizes Myc oncoproteins

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

SIRT2 activity is required for the survival of C6 glioma cells

(2011) Xin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile

(2011) Dante Rotili et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

(2011) L. Dan et al.   HAEMATOLOGICA

Nicotinamide Inhibits Growth of Carcinogen Induced Mouse Bladder Tumor and Human Bladder Tumor Xenograft Through Up-Regulation of RUNX3 and p300

(2011) Wun-Jae Kim et al.   JOURNAL OF UROLOGY

SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

(2011) Glenn M. Marshall et al.   PLoS Genetics

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

(2010) Yanze Li et al.   GENES TO CELLS

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

(2010) G M Marshall et al.   ONCOGENE

Myc proteins as therapeutic targets

(2010) W C Gustafson et al.   ONCOGENE

Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity

(2009) Yingjia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

(2009) B Yang et al.   CELL DEATH AND DIFFERENTIATION

Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors

(2009) Tao Liu et al.   EUROPEAN JOURNAL OF CANCER

Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation

(2009) Andrew E. L. Tee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY

Transcription-independent functions of MYC: regulation of translation and DNA replication

(2008) Michael D. Cole et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE