Article
Biochemistry & Molecular Biology
Irina V. Zhigacheva, Irina F. Rusina, Natalia I. Krikunova, Aleksandr N. Goloschapov, Timur L. Veprintsev, Olga I. Yablonskaya, Aleksei V. Trofimov
Summary: Increased generation of reactive oxygen species (ROS) by stressed mitochondria causes lipid peroxidation (LPO), damaging cell membranes' lipid bilayer due to interactions with polyunsaturated fatty acids. Chemical preparations reducing excessive ROS production by mitochondria are believed to protect against oxidative stress. Resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were investigated as potential protectors, maintaining mitochondrial functionality under stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Feng Wei, Qing Nian, Maoyuan Zhao, Yueqiang Wen, Yi Yang, Jundong Wang, Zhelin He, Xiaoyan Chen, Xiang Yin, Jian Wang, Xiao Ma, Yu Chen, Peimin Feng, Jinhao Zeng
Summary: Research has found that many natural products can suppress the progression, metastasis, and invasion of colorectal cancer by targeting mitochondria. These natural products inhibit the mitochondrial respiratory chain, increase ROS, and disrupt mitochondrial membrane potential. They also induce cell apoptosis by targeting mitochondria through various apoptotic signaling pathways. Natural products with low toxicity, high efficacy, and multi-targeted properties have great potential for overcoming the challenges of colorectal cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Review
Cardiac & Cardiovascular Systems
Elizabeth Murphy, Julia Liu
Summary: Cardiomyocytes have a high density of mitochondria, which play a crucial role in energy production and cellular functions. The regulation of mitochondrial calcium and reactive oxygen species is important in the development of cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Shuo Geng, RuiCi Lin, Yajun Wu, Jing Wang, Liwu Li
Summary: Innate immune cells adopt distinct memory states during the pathogenesis of acute and chronic inflammatory diseases, with reactive oxygen species (ROS) playing key roles in their programming dynamics. ROS modulate the adaptation of innate leukocytes to inflammatory signals and facilitate fundamental processes such as priming, tolerance, and exhaustion. They can be generated at different subcellular compartments and may differentially facilitate innate memory dynamics.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Giulio Bresciani, Jakub Cervinka, Hana Kostrhunova, Lorenzo Biancalana, Marco Bortoluzzi, Guido Pampaloni, Vojtech Novohradsky, Viktor Brabec, Fabio Marchetti, Jana Kasparkova
Summary: This study reports the synthesis of novel diiron complexes with an indole-functionalized vinyliminium ligand and investigates their antiproliferative activity and mechanism of action. The complexes display selective cytostatic effects towards cancer cells, induce apoptosis, and interact with mitochondrial DNA and proteins, as well as exhibit reactive oxygen species (ROS)-scavenging properties and antioxidant activity. This study highlights the importance and therapeutic potential of these diiron complexes as anticancer agents.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Wu-Sheng Sun, Hoon Jang, Mi-Ryung Park, Keon Bong Oh, Haesun Lee, Seongsoo Hwang, Li-Jie Xu, In-Sul Hwang, Jeong-Woong Lee
Summary: The study suggests that N-acetyl-L-cysteine (NAC) supplementation during in vitro culture has beneficial effects on bovine oocytes and embryos by reducing intracellular reactive oxygen species (ROS) and promoting intracellular glutathione levels. NAC also influences early embryonic development with both dose-dependent and stage-specific effects, leading to improved developmental rates and reduced apoptosis.
Article
Chemistry, Multidisciplinary
Shu Song, Yue Ding, Guo-liang Dai, Yue Zhang, Meng-ting Xu, Jie-ru Shen, Ting-ting Chen, Yun Chen, Guo-liang Meng
Summary: The study showed that reduced expression of SIRT3 in diabetic cardiomyopathy worsens cardiac dysfunction, myocardial injury, ROS accumulation, necroptosis, and inflammation, ultimately exacerbating the condition. This suggests SIRT3 could be a potential molecular target for preventing and treating diabetic cardiomyopathy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Takashi Matsumura, Masaya Ono, Satoshi Osada, Fumikazu Matsuhisa, Masanori Ochiai, Yoichi Hayakawa
Summary: This study demonstrates that N-acetyloxfenicine (NAO) is a potent inducer of mitohormesis, exhibiting higher thermotolerance than the endogenous mitohormesis inducer, N-acetyltyrosine (NAT). NAO triggers hormetic effects through transient perturbation of mitochondria, leading to increased ROS production and enhanced expression of antioxidant enzyme genes via activation of FoxO transcription factors. Moreover, NAO pretreatment effectively suppresses lipid peroxidation in mice and inhibits the growth of colorectal cancer cells in nude mice.
Article
Medicine, Research & Experimental
Reyes Benot-Dominguez, Maria Grazia Tupone, Vanessa Castelli, Michele d'Angelo, Elisabetta Benedetti, Massimiliano Quintiliani, Benedetta Cinque, Iris Maria Forte, Maria Grazia Cifone, Rodolfo Ippoliti, Barbara Barboni, Antonio Giordano, Annamaria Cimini
Summary: The study revealed the potential of Olive Leaf Extract in inhibiting the viability of breast and ovarian cancer cells through anti-proliferative and pro-apoptotic activities. The extract induced cell cycle arrest and increased apoptotic cell death by affecting mitochondrial functionality and causing oxidative stress. Mitochondrial ROS generation was identified as the primary mechanism of the extract's antitumor activity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Simona Reina, Stefano Conti Nibali, Marianna Flora Tomasello, Andrea Magri, Angela Messina, Vito De Pinto
Summary: Unraveling the role of VDAC3 within living cells is challenging but it is certain that this protein plays an important role in mitochondrial ROS homeostasis. Experimental evidence shows that VDAC3 cysteines are indispensable for the protein's ability to counteract ROS-induced oxidative stress.
Review
Biochemistry & Molecular Biology
Marcos Martinez-Banaclocha
Summary: Significant progress has been made in understanding the pathophysiology of age-associated neurodegenerative diseases in the last twenty years. However, there is still a lack of clinically significant therapeutic advancement in the prevention and treatment of these diseases. It is important to focus on early diagnosis and prompt intervention to slow down disease progression and improve patients' quality of life.
Review
Biochemistry & Molecular Biology
Yoichi Hayakawa
Summary: Insects have adaptations to survive in harsh terrestrial environments, including the ability to rapidly acclimate to temperature changes. Recent research has identified N-acetyltyrosine (NAT) as a factor inducing thermotolerance in insects, with NAT treatment also improving heat stress responses in mice.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Xiaoxi Li, Sai Luo, Xinyao Chen, Shasha Li, Lijun Hao, Dan Yang
Summary: This study found that adipose-derived stem cells (ADSCs) can inhibit skin inflammation induced by Propionibacterium acnes by blocking the NLRP3 inflammasome and reducing the secretion of IL-1 beta.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Gastroenterology & Hepatology
Emily S. Wires, Kathleen A. Trychta, Susanne Back, Agnieszka Sulima, Kenner C. Rice, Brandon K. Harvey
JOURNAL OF HEPATOLOGY
(2017)
Article
Biochemical Research Methods
Christopher T. Richie, Leslie R. Whitaker, Keith W. Whitaker, Julie Necarsulmer, Heather A. Baldwin, Yajun Zhang, Lowella Fortuno, Josh J. Hinkle, Pyry Koivula, Mark J. Henderson, Wenzhi Sun, Kai Wang, Jeffrey C. Smith, Jim Pickel, Na Ji, Bruce T. Hope, Brandon K. Harvey
JOURNAL OF NEUROSCIENCE METHODS
(2017)
Review
Neurosciences
Maryna Koskela, Susanne Back, Vootele Voikar, Christopher T. Richie, Andrii Domanskyi, Brandon K. Harvey, Mikko Airavaara
NEUROBIOLOGY OF DISEASE
(2017)
Article
Multidisciplinary Sciences
Emily S. Wires, Mark J. Henderson, Xiaokang Yan, Susanne Back, Kathleen A. Trychta, Molly H. Lutrey, Brandon K. Harvey
Article
Clinical Neurology
Jenni E. Anttila, Keith W. Whitaker, Emily S. Wires, Brandon K. Harvey, Mikko Airavaara
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2017)
Article
Multidisciplinary Sciences
Juan L. Gomez, Jordi Bonaventura, Wojciech Lesniak, William B. Mathews, Polina Sysa-Shah, Lionel A. Rodriguez, Randall J. Ellis, Christopher T. Richie, Brandon K. Harvey, Robert F. Dannals, Martin G. Pomper, Antonello Bonci, Michael Michaelides
Article
Neurosciences
Xuan Li, Maria B. Carreria, Kailyn R. Witonsky, Tamara Zeric, Olivia M. Lofaro, Jennifer M. Bossert, Jianjun Zhang, Felicia Surjono, Christopher T. Richie, Brandon K. Harvey, Hyeon Son, Christopher W. Cowan, Eric J. Nestler, Yavin Shaham
BIOLOGICAL PSYCHIATRY
(2018)
Article
Endocrinology & Metabolism
L. J. Zallar, B. J. Tunstall, C. T. Richie, Y. J. Zhang, Z. B. You, E. L. Gardner, M. Heilig, J. Pickel, G. F. Koob, L. F. Vendruscolo, B. K. Harvey, L. Leggio
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Clinical Neurology
Anna-Maija Penttinen, Ilmari Parkkinen, Merja H. Voutilainen, Maryna Koskela, Susanne Back, Anna Their, Christopher T. Richie, Andrii Domanskyi, Brandon K. Harvey, Raimo K. Tuominen, Liina Nevalaita, Mart Saarma, Mikko Airavaara
FRONTIERS IN NEUROLOGY
(2018)
Article
Multidisciplinary Sciences
Kert Matlik, Jenni E. Anttila, Tseng Kuan-Yin, Olli-Pekka Smolander, Emmi Pakarinen, Leevi Lehtonen, Usama Abo-Ramadan, Paivi Lindholm, Congjun Zheng, Brandon Harvey, Urmas Arumae, Maria Lindahl, Mikko Airavaara
Article
Neurosciences
Craig Myrum, Joshua Kittleson, Supriyo De, Bonnie R. Fletcher, James Castellano, Gautam Kundu, Kevin G. Becker, Peter R. Rapp
MOLECULAR NEUROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Emily S. Wires, Kathleen A. Trychta, Lacey M. Kennedy, Brandon K. Harvey
Summary: The KDEL receptor retrieval pathway is crucial for maintaining ER resident proteins, but can be disrupted by perturbations like calcium depletion and UPR activation. Recent data shows that KDEL receptors are activated through the IRE1/XBP1 signaling pathway during UPR as an adaptive response to cellular stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Yun-Hsiang Chen, Kuo-Jen Wu, Wei Hsieh, Brandon K. Harvey, Barry J. Hoffer, Yun Wang, Seong-Jin Yu
Summary: The study demonstrates that intervention with AAV-NAC32 on alpha-Synuclein in animals can improve PD-like symptoms, including reducing bradykinesia and restoring tyrosine hydroxylase loss. This research provides hope for this intervention technique as a potential therapeutic candidate for PD.
Article
Biology
BreAnna Cameron, Elin Lehrmann, Tien Chih, Joseph Walters, Richard Buksch, Sara Snyder, Joy Goffena, Frances Lefcort, Kevin G. Becker, Lynn George
Summary: Elongator dysfunction is linked to various neurodevelopmental and neurodegenerative disorders, mainly through the modification of tRNA and translational regulation of specific genes. H2a.z is identified as an indirect target of Elongator, affecting Notch signaling. Using histone deacetylase inhibitor during neurogenesis can correct gene expression and rescue neuron development in Elongator-deficient embryos.
Article
Neurosciences
Jenni E. Anttila, Katrina Albert, Emily S. Wires, Kert Matlik, Lisa C. Loram, Linda R. Watkins, Kenner C. Rice, Yun Wang, Brandon K. Harvey, Mikko Airavaara