Miscoding-induced stalling of substrate translocation on the bacterial ribosome

Thio-Modification of tRNA at the Wobble Position as Regulator of the Kinetics of Decoding and Translocation on the Ribosome

(2017) Namit Ranjan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale

(2016) Manuel F Juette et al.   NATURE METHODS

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways

(2015) Shannon Yan et al.   CELL

Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis

(2015) Anneli Borg et al.   JOURNAL OF MOLECULAR BIOLOGY

Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome

(2015) Lili K. Doerfel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The quantitative and condition-dependent Escherichia coli proteome

(2015) Alexander Schmidt et al.   NATURE BIOTECHNOLOGY

Mechanisms of ribosome rescue in bacteria

(2015) Kenneth C. Keiler   NATURE REVIEWS MICROBIOLOGY

Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome

(2015) Jingji Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance in Pseudomonas aeruginosa

(2015) Andrei Rajkovic et al.   mBio

Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

(2015) Michael R. Wasserman et al.   Nature Communications

Structural and binding studies of peptidyl-tRNA hydrolase fromPseudomonas aeruginosaprovide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase

(2014) Avinash Singh et al.   BIOCHEMICAL JOURNAL

Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis

(2014) Wolf Holtkamp et al.   BIOESSAYS

Programmed –1 Frameshifting by Kinetic Partitioning during Impeded Translocation

(2014) Neva Caliskan et al.   CELL

Elongation Factor P and Modifying Enzyme PoxA Are Necessary for Virulence of Shigella flexneri

(2014) Hannah E. Marman et al.   INFECTION AND IMMUNITY

Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome

(2014) Anneli Borg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic pathways of −1 translational frameshifting

(2014) Jin Chen et al.   NATURE

The safety dance: biophysics of membrane protein folding and misfolding in a cellular context

(2014) Jonathan P. Schlebach et al.   QUARTERLY REVIEWS OF BIOPHYSICS

How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation

(2014) J. Zhou et al.   SCIENCE

Protein mistranslation: friend or foe?

(2014) Liuís Ribas de Pouplana et al.   TRENDS IN BIOCHEMICAL SCIENCES

tmRNA-mediated trans-translation as the major ribosome rescue system in a bacterial cell

(2014) Hyouta Himeno et al.   Frontiers in Genetics

Bacterial Toxin RelE: A Highly Efficient Ribonuclease with Exquisite Substrate Specificity Using Atypical Catalytic Residues

(2013) Meghan A. Griffin et al.   BIOCHEMISTRY

Elongation Factor Ts Directly Facilitates the Formation and Disassembly of theEscherichia coliElongation Factor Tu·GTP·Aminoacyl-tRNA Ternary Complex

(2013) Benjamin J. Burnett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii

(2013) Sanket Kaushik et al.   PLoS One

Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation

(2013) D. J. F. Ramrath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the ribosome with elongation factor G trapped in the pretranslocation state

(2013) A. F. Brilot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

(2013) L. Peil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies of translational misreading in vivo show that the ribosome very efficiently discriminates against most potential errors

(2013) N. Manickam et al.   RNA

Crystal Structures of EF-G-Ribosome Complexes Trapped in Intermediate States of Translocation

(2013) J. Zhou et al.   SCIENCE

Unraveling the dynamics of ribosome translocation

(2012) Jin Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A new understanding of the decoding principle on the ribosome

(2012) Natalia Demeshkina et al.   NATURE

The complex of tmRNA–SmpB and EF-G on translocating ribosomes

(2012) David J. F. Ramrath et al.   NATURE

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rotation of the head of the 30S ribosomal subunit during mRNA translocation

(2012) Z. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

(2012) P. Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

(2012) A. G. Hinnebusch et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms and implications of programmed translational frameshifting

(2012) Jonathan D. Dinman   Wiley Interdisciplinary Reviews-RNA

Loss of Elongation Factor P Disrupts Bacterial Outer Membrane Integrity

(2011) S. B. Zou et al.   JOURNAL OF BACTERIOLOGY

The ribosome uses two active mechanisms to unwind messenger RNA during translation

(2011) Xiaohui Qu et al.   NATURE

Messenger RNA interactions in the decoding center control the rate of translocation

(2011) Prashant K Khade et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

mRNA translocation occurs during the second step of ribosomal intersubunit rotation

(2011) Dmitri N Ermolenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic code translation displays a linear trade-off between efficiency and accuracy of tRNA selection

(2011) M. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the molecular determinants of EF-G catalyzed translocation

(2011) L. Wang et al.   RNA

Conformational Sampling of Aminoacyl-tRNA during Selection on the Bacterial Ribosome

(2010) Peter Geggier et al.   JOURNAL OF MOLECULAR BIOLOGY

PoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica

(2010) William Wiley Navarre et al.   MOLECULAR CELL

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

(2010) Andreas H. Ratje et al.   NATURE

Cellular mechanisms that control mistranslation

(2010) Noah M. Reynolds et al.   NATURE REVIEWS MICROBIOLOGY

Correlated conformational events in EF-G and the ribosome regulate translocation

(2010) James B Munro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosomal Translocation: One Step Closer to the Molecular Mechanism

(2009) Shinichiro Shoji et al.   ACS Chemical Biology

Mitigating Unwanted Photophysical Processes for Improved Single-Molecule Fluorescence Imaging

(2009) Richa Dave et al.   BIOPHYSICAL JOURNAL

A fast dynamic mode of the EF-G-bound ribosome

(2009) James B Munro et al.   EMBO JOURNAL

Aminoglycoside activity observed on single pre-translocation ribosome complexes

(2009) Michael B Feldman et al.   Nature Chemical Biology

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spontaneous formation of the unlocked state of the ribosome is a multistep process

(2009) J. B. Munro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome

(2009) G. Blaha et al.   SCIENCE

Structures of the Ribosome in Intermediate States of Ratcheting

(2009) W. Zhang et al.   SCIENCE

The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State

(2009) Y.-G. Gao et al.   SCIENCE

Navigating the ribosome's metastable energy landscape

(2009) James B. Munro et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Spontaneous Intersubunit Rotation in Single Ribosomes

(2008) Peter V. Cornish et al.   MOLECULAR CELL

Quality control by the ribosome following peptide bond formation

(2008) Hani S. Zaher et al.   NATURE

An Oxygen Scavenging System for Improvement of Dye Stability in Single-Molecule Fluorescence Experiments

(2007) Colin Echeverría Aitken et al.   BIOPHYSICAL JOURNAL