The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Effects of amino acid starvation on RelA diffusive behavior in liveEscherichia coli

(2015) Wenting Li et al.   MOLECULAR MICROBIOLOGY

Structure of the E. coli ribosome–EF-Tu complex at

(2015) Niels Fischer et al.   NATURE

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone

(2015) Wieland Steinchen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution

(2015) Stefan Arenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

(2014) Stefan Arenz et al.   MOLECULAR CELL

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

(2014) Stefan Arenz et al.   Nature Communications

The ribosome triggers the stringent response by RelA via a highly distorted tRNA

(2013) Xabier Agirrezabala et al.   EMBO REPORTS

Design, synthesis and structure–activity relationship of novel Relacin analogs as inhibitors of Rel proteins

(2013) Ezequiel Wexselblatt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

Bacterial stress responses as determinants of antimicrobial resistance

(2012) K. Poole   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

(2012) Thomas Becker et al.   NATURE

Relacin, a Novel Antibacterial Agent Targeting the Stringent Response

(2012) Ezequiel Wexselblatt et al.   PLoS Pathogens

The Stringent Response of Staphylococcus aureus and Its Impact on Survival after Phagocytosis through the Induction of Intracellular PSMs Expression

(2012) Tobias Geiger et al.   PLoS Pathogens

Dependence of RelA-Mediated (p)ppGpp Formation on tRNA Identity

(2011) Roshani Payoe et al.   BIOCHEMISTRY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Single-molecule investigations of the stringent response machinery in living bacterial cells

(2011) B. P. English et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ppGpp Conjures Bacterial Virulence

(2010) Z. D. Dalebroux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

GTPase activation of elongation factor EF-Tu by the ribosome during decoding

(2009) Jan-Christian Schuette et al.   EMBO JOURNAL

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

(2009) T. M. Schmeing et al.   SCIENCE

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Molecular Mechanism of Drug-Dependent Ribosome Stalling

(2008) Nora Vazquez-Laslop et al.   MOLECULAR CELL