Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells

Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition

(2016) Yi-ming Ma et al.   ACTA PHARMACOLOGICA SINICA

Caspase dependent apoptotic inhibition of melanoma and lung cancer cells by tropical Rubus extracts

(2016) Blassan Plackal Adimuriyil George et al.   BIOMEDICINE & PHARMACOTHERAPY

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction

(2016) Pavla Plačková et al.   FREE RADICAL BIOLOGY AND MEDICINE

Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways

(2016) HANA OH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

(2016) Chi-Ming Chan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway

(2016) KA HWI KIM et al.   ONCOLOGY REPORTS

Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1)

(2015) Ra Ham Lee et al.   DRUG DEVELOPMENT RESEARCH

Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives

(2015) Debarshi Kar Mahapatra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

(2015) D.X. Li et al.   GENETICS AND MOLECULAR RESEARCH

Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft

(2015) Jin Hyoung Cho et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma

(2015) JUNG JAE CHO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1

(2015) WOONG BANG et al.   ONCOLOGY REPORTS

Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

(2015) Ammad Ahmad Farooqi et al.   TUMOR BIOLOGY

Antimetastatic Effects of Licochalcone B on Human Bladder Carcinoma T24 by Inhibition of Matrix Metalloproteinases-9 and NF-кB Activity

(2014) Hong Zhao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Short and Efficient Synthesis of Licochalcone B and D Through Acid-Mediated Claisen-Schmidt Condensation

(2014) Zengtao Wang et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

(2014) Ju-Hyung Park et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis

(2014) Xuan Yuan et al.   FOOD AND CHEMICAL TOXICOLOGY

Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma

(2014) JUNG JAE CHO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells

(2014) Hyeon-Ok Jin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Apoptotic effects of 7,8-dihydroxyflavone in human oral squamous cancer cells through suppression of Sp1

(2014) RA HAM LEE et al.   ONCOLOGY REPORTS

Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells

(2013) Min Ho Han et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice

(2013) Yu Fu et al.   FOOD CHEMISTRY

Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells

(2013) Yuan Zhou et al.   Asian Pacific Journal of Tropical Medicine

Cell cycle regulation by the intrinsically disordered proteins p21 and p27

(2012) Mi-Kyung Yoon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A systematic review of worldwide incidence of nonmelanoma skin cancer

(2012) A. Lomas et al.   BRITISH JOURNAL OF DERMATOLOGY

Does hormone replacement therapy and use of oral contraceptives increase the risk of non-melanoma skin cancer?

(2012) Fatima Birch-Johansen et al.   CANCER CAUSES & CONTROL

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

PKC  Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4-ATF3/CHOP Axis in Human Lung Cancer Cells

(2012) L. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2

(2012) YONG-SIK KIM et al.   ONCOLOGY REPORTS

Small Hepatocellular Carcinomas: Improved Sensitivity by Combining Gadoxetic Acid–enhanced and Diffusion-weighted MR Imaging Patterns

(2012) Min Jung Park et al.   RADIOLOGY

Targeting Mcl-1 for the therapy of cancer

(2011) Bridget A Quinn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The use of brachytherapy in the treatment of nonmelanoma skin cancer: A review

(2011) Murad Alam et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation

(2011) In Young Kim et al.   NEURO-ONCOLOGY

Activation of Multiple Apoptotic Pathways in Human Nasopharyngeal Carcinoma Cells by the Prenylated Isoflavone, Osajin

(2011) Tsung-Teng Huang et al.   PLoS One

Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L

(2010) Hong Zhu et al.   CANCER LETTERS

ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteins

(2010) Sahdeo Prasad et al.   CANCER RESEARCH

Signaling through C/EBP Homologous Protein and Death Receptor 5 and Calpain Activation Differentially Regulate THP-1 Cell Maturation-Dependent Apoptosis Induced by Shiga Toxin Type 1

(2010) M.-S. Lee et al.   INFECTION AND IMMUNITY

Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1

(2010) J-A Shin et al.   ORAL DISEASES

Skin Cancer of the Head and Neck

(2010) Yun-Hsuan Ouyang   Seminars in Plastic Surgery

Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-κB p65 in LPS signaling pathway

(2009) Jun-ichi Furusawa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sumoylation of Specificity Protein 1 Augments Its Degradation by Changing the Localization and Increasing the Specificity Protein 1 Proteolytic Process

(2008) Yi-Ting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY