Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells

(2015) Yu-Jia Chang et al.   TUMOR BIOLOGY

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling

(2015) Elizabeth Rico-Bautista et al.   Oncotarget

Restoring TRAIL Mediated Signaling in Ovarian Cancer Cells

(2014) Ammad Ahmad Farooqi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

ω-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells

(2014) Kyung Mi Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells

(2014) Jia Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WITHDRAWN: Hypericin-based Photodynamic Therapy Induces a Tumor-Specific Immune Response and an Effective DC-based cancer Immunotherapy

(2014) Yuanhong Zheng et al.   BIOCHEMICAL PHARMACOLOGY

Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways

(2014) Huai-Min Chen et al.   BMC Complementary and Alternative Medicine

Targeting Cancer Cells via the Reactive Oxygen Species-Mediated Unfolded Protein Response with a Novel Synthetic Polyphenol Conjugate

(2014) S. Y. Shin et al.   CLINICAL CANCER RESEARCH

Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis through Up-regulation of Death Receptor 5 (DR5) by Zerumbone and Celecoxib

(2014) Makoto Edagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells

(2014) Xiaofei Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs

(2014) Ammad Farooqi et al.   Marine Drugs

Methanolic Extracts of Solieria robusta Inhibits Proliferation of Oral Cancer Ca9-22 Cells via Apoptosis and Oxidative Stress

(2014) Yii-Huei Yen et al.   MOLECULES

Brefeldin A Reduces Anchorage-Independent Survival, Cancer Stem Cell Potential and Migration of MDA-MB-231 Human Breast Cancer Cells

(2014) Chao-Neng Tseng et al.   MOLECULES

Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

(2014) Tae Hyong Kim et al.   NEURO-ONCOLOGY

The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells

(2014) Mei Ling Jin et al.   NEUROTOXICOLOGY

Ampelopsin Induces Cell Growth Inhibition and Apoptosis in Breast Cancer Cells through ROS Generation and Endoplasmic Reticulum Stress Pathway

(2014) Yong Zhou et al.   PLoS One

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades

(2014) Shaohua Chen et al.   PLoS One

Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells

(2014) Eun-Ryeong Hahm et al.   PROSTATE

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway

(2014) Juan Xie et al.   TUMOR BIOLOGY

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Therapeutic Implications of Immunogenic Cell Death in Human Cancer

(2014) Fabio Palombo et al.   Frontiers in Immunology

Trial Watch

(2014) Erika Vacchelli et al.   OncoImmunology

Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells

(2013) A-Young Choi et al.   APOPTOSIS

Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells

(2013) Shuying Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer immunogenicity, danger signals, and DAMPs: What, when, and how?

(2013) Abhishek D. Garg et al.   BIOFACTORS

Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

(2013) Jin-Ching Lee et al.   Cancer Cell International

Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model

(2013) Hung-Chuan Pan et al.   CARCINOGENESIS

Proteomic analysis reveals that pardaxin triggers apoptotic signaling pathways in human cervical carcinoma HeLa cells: cross talk among the UPR, c-Jun and ROS

(2013) Tsui-Chin Huang et al.   CARCINOGENESIS

Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation

(2013) Mi Jin Yoon et al.   CARCINOGENESIS

Mapping the crossroads of immune activation and cellular stress response pathways

(2013) Nuno Cláudio et al.   EMBO JOURNAL

Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells

(2013) Toshio Inoue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cariporide sensitizes leukemic cells to tumor necrosis factor related apoptosis-inducing ligand by up-regulation of death receptor 5 via endoplasmic reticulum stress–CCAAT/enhancer binding protein homologous protein dependent mechanism

(2013) Huawen Li et al.   LEUKEMIA & LYMPHOMA

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Brefeldin A Effectively Inhibits Cancer Stem Cell-Like Properties and MMP-9 Activity in Human Colorectal Cancer Colo 205 Cells

(2013) Chao-Neng Tseng et al.   MOLECULES

Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution

(2013) Hyung Lim Elfrink et al.   MOLECULES AND CELLS

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Natural Compounds as Modulators of NADPH Oxidases

(2013) Tullia Maraldi   Oxidative Medicine and Cellular Longevity

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

(2013) Hongmei Luo et al.   PLoS One

Casticin Potentiates TRAIL-Induced Apoptosis of Gastric Cancer Cells through Endoplasmic Reticulum Stress

(2013) Yuan Zhou et al.   PLoS One

Nuclear Translocation of B-Cell-Specific Transcription Factor, BACH2, Modulates ROS Mediated Cytotoxic Responses in Mantle Cell Lymphoma

(2013) Zheng Chen et al.   PLoS One

Many faces of DAMPs in cancer therapy

(2013) O Krysko et al.   Cell Death & Disease

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

(2013) W Hou et al.   Cell Death & Disease

Abstract 1321: A novel prevention method against re-obstruction of titanium alloy stent for biliary malignancy using generation of hydroxyl radical under ultrasonic irradiation

(2012) Tomonori Fujimura et al.   CANCER RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

NG, a novel PABA/NO-based oleanolic acid derivative, induces Human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway

(2012) Ling Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of Apoptosis by 11-Dehydrosinulariolide via Mitochondrial Dysregulation and ER Stress Pathways in Human Melanoma Cells

(2012) Tzu-Rong Su et al.   Marine Drugs

Pardaxin, a Fish Antimicrobial Peptide, Exhibits Antitumor Activity toward Murine Fibrosarcoma in Vitro and in Vivo

(2012) Shu-Ping Wu et al.   Marine Drugs

PKC  Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4-ATF3/CHOP Axis in Human Lung Cancer Cells

(2012) L. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of Peroxiredoxin 4 in Glioblastoma Cells Increases Apoptosis and Reduces Tumor Growth

(2012) Tae Hyong Kim et al.   PLoS One

Wogonin Induced Calreticulin/Annexin A1 Exposure Dictates the Immunogenicity of Cancer Cells in a PERK/AKT Dependent Manner

(2012) Yong Yang et al.   PLoS One

Honokiol Attenuates the Severity of Acute Pancreatitis and Associated Lung Injury via Acceleration of Acinar Cell Apoptosis

(2012) Te I Weng et al.   SHOCK

Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines

(2012) Mu-Yun Pan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2α/CHOP-dependent manner

(2012) Dong-Oh Moon et al.   TOXICOLOGY IN VITRO

Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase

(2011) Jung Lee Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: Involvement of ROS-dependent ER-stress

(2011) Dong-Oh Moon et al.   BIOCHEMICAL PHARMACOLOGY

5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells

(2011) Jian-Feng Yang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer

(2011) Luiz Fernando Zerbini et al.   CELL CYCLE

Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1

(2011) Zhengguang Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Ubiquitin-Proteasomal Degradation of COX-2 in TGF-β Stimulated Human Endometrial Cells Is Mediated Through Endoplasmic Reticulum Mannosidase I

(2011) Mohan Singh et al.   ENDOCRINOLOGY

Pardaxin, an Antimicrobial Peptide, Triggers Caspase-Dependent and ROS-Mediated Apoptosis in HT-1080 Cells

(2011) Tsui-Chin Huang et al.   Marine Drugs

Targeting Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase 2 by Curcumin Induces ER Stress-Associated Apoptosis for Treating Human Liposarcoma

(2011) L. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Protective effects of atypical antipsychotic drugs against MPP+-induced oxidative stress in PC12 cells

(2011) Sung Woo Park et al.   NEUROSCIENCE RESEARCH

Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells

(2011) Jung-Chieh Hsu et al.   PEPTIDES

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells

(2011) Jin-Woo Jeong et al.   TOXICOLOGY IN VITRO

Modulating stress responses by the UPRosome: A matter of life and death

(2011) Ute Woehlbier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway

(2010) Dong-Oh Moon et al.   CANCER LETTERS

Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

(2010) Ji Hyun Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Molecular Symbiosis of CHOP and C/EBP  Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced Apoptosis

(2010) C.-B. Chiribau et al.   MOLECULAR AND CELLULAR BIOLOGY

Cannabidiol Enhances the Inhibitory Effects of  9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival

(2010) J. P. Marcu et al.   MOLECULAR CANCER THERAPEUTICS

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation

(2009) Bao-Qin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress

(2009) Ying-Ju Chen et al.   CANCER LETTERS

Nitrosative Stress-Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

(2009) D. M. Townsend et al.   CANCER RESEARCH

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway

(2008) Song-Shei Lin et al.   CANCER LETTERS

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of α-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death

(2008) Kunio Miyake et al.   NEUROTOXICOLOGY