Article
Plant Sciences
Renato Dantas-Medeiros, Allanny Alves Furtado, Ana C. Zanatta, Manoela Torres-Rego, Estela Mariana Guimaraes Lourenco, Jovelina Samara Ferreira Alves, Eder Galinari, Hugo Alexandre de Oliveira Rocha, Gerlane Coelho Bernardo Guerra, Wagner Vilegas, Thiago Antonio de Sousa Araujo, Matheus de Freitas Fernandes-Pedrosa, Silvana Maria Zucolotto
Summary: The study aimed to characterize the phytochemical profile, anti-inflammatory and antioxidant potential of Commiphora leptophloeos leaf extract. The results showed that the extract exhibited significant anti-inflammatory effects by modulating cytokine levels, decreasing TNF-alpha levels, increasing IL-10 levels, and inhibiting nitric oxide production in RAW 264.7 cells activated by LPS.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shi-Fa Ruan, Yi Hu, Wen-Feng Wu, Qun-Qun Du, Zhu-Xian Wang, Ting-Ting Chen, Qun Shen, Li Liu, Cui-Ping Jiang, Hui Li, Yankui Yi, Chun-Yan Shen, Hong-Xia Zhu, Qiang Liu
Summary: This study revealed the mechanism of licorice flavonoids in treating acne by regulating metabolic balance and microbial balance, providing theoretical guidance for the development and clinical application of the drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Agriculture, Multidisciplinary
Weisong Wu, Limei Liu, Yingwei Zhu, Jingbin Ni, Jian Lu, Xiaoli Wang, Li Ma, Yanjun Jiang
Summary: In patients with inflammatory bowel diseases (IBDs), the immune system is disrupted and the intestinal barrier function is compromised. Six zinc-flavonoid particles were produced and tested for their cytocompatibility and ability to scavenge H2O2, free radicals, and LPS-induced ROS. The zinc-rutin particles (W-ZnRT) showed promising results, exhibiting high cell viability, efficient scavenging abilities, and the ability to restore normal levels of intracellular ROS. In addition, W-ZnRT was found to be more effective than rutin alone in treating chronic colitis in mice, improving intestinal permeability, reducing proinflammatory factors, and maintaining intestinal barrier function. Overall, these findings suggest that W-ZnRT is a safe and efficient therapeutic strategy for IBD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Fangfang Yang, Yameng Song, Mengting Ma, Qin Wang, Yan Liu, Aiping Hui, Aiqin Wang
Summary: This study incorporated licorice flavonoids (LF) into ZnO/attapulgite (APT) to form organic-inorganic nanocomposites. The results showed that LF/ZnO/APT had enhanced antimicrobial and antioxidant activities, making it a potential alternative to antibiotics for preventing and treating bacterial infections in animals.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Shenggang Yin, Ting You, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, Gang Tian, Xiaoling Chen, Jingyi Cai, Bo Kang, Hua Zhao
Summary: This study investigated the effects of dietary licorice flavonoids powder (LFP) supplementation on antioxidant capacity and immunity in weaned piglets. The results showed that LFP supplementation improved the liver index and antioxidant capacity, reduced serum cholesterol levels, and alleviated inflammation in immune organs of piglets.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Plant Sciences
Zhixin Zhang, Lin Yang, Jiaming Hou, Shaokai Tian, Ying Liu
Summary: Licorice flavonoids demonstrate anticancer activities by inhibiting cancer cells through regulating cell cycle and multiple signaling pathways. They have pleiotropic effects on cell growth, survival, and signaling, showing great therapeutic potential in cancer treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yi Hu, Yufan Wu, CuiPing Jiang, Zhuxian Wang, Chunyan Shen, Zhaoming Zhu, Hui Li, Quanfu Zeng, Yaqi Xue, Yuan Wang, Li Liu, Yankui Yi, Hongxia Zhu, Qiang Liu
Summary: This study used multiple methods to explore the molecular mechanism of licorice flavonoids (LCFs) in anti-melanoma activity. The results showed that LCF has anti-melanoma activity and identified the active components and targets. Pharmacophore models were established to predict the activity of LCF compounds, and molecular docking and dynamics simulation confirmed the effectiveness of the pharmacophore.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yi Hu, Zhuxian Wang, Chunyan Shen, CuiPing Jiang, Zhaoming Zhu, Peiyi Liang, Hui Li, Quanfu Zeng, Yaqi Xue, Yufan Wu, Yuan Wang, Li Liu, Hongxia Zhu, Yankui Yi, Qiang Liu
Summary: Licorice flavonoids (LCFs) have been studied for their antioxidant activity using various methods including network pharmacology, ADMET, density functional theory (DFT), molecular docking, and molecular dynamics (MD) simulation. The study identified kumatakenin, licoflavonol, and topazolin as key antioxidant components in LCF, and demonstrated their interaction with target proteins to form stable complexes. The study also established the relationship between the pK(a) value of LCF and its antioxidant activity under solvent-mediated effects.
ARCHIV DER PHARMAZIE
(2023)
Review
Medicine, Research & Experimental
Abhijit Das, Ratna Baidya, Tania Chakraborty, Akash Kumar Samanta, Souvik Roy
Summary: The pharmacological characteristics of phytochemicals have sparked interest in their application in disease management, particularly in anticancer potential. Taxifolin, a phytochemical, has shown significant activity in inhibiting inflammation, cancer, and other diseases. Research indicates that taxifolin exhibits relatively important activity in suppressing cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Payam Bayat, Maral Farshchi, Mozhdeh Yousefian, Mahmoud Mahmoudi, Rezvan Yazdian-Robati
Summary: Research indicates that flavonoids can effectively alleviate the severity of multiple sclerosis and experimental autoimmune encephalomyelitis, showing potential therapeutic effects and paving the way for improving MS therapeutic strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Tri Nhut Pham, Xuan Tuyen Nguyen, Trong Doan Phan, Tien Dung Le, Thi Bach Tuyet Nguyen, Thi Phuong Lien Hoang, Long Giang Bach
Summary: The study tested an aqueous extract from Coptosapelta flavescens Korth for antioxidant and anti-inflammatory activities, finding significant effects on arthritis in mice induced by Complete Freund's adjuvant. The extract showed a reduction in inflammatory symptoms and limited cartilage tissue damage.
Article
Agricultural Engineering
Zhonghua Luo, Xude Wang, Qingqing Gao, Zhenghong Guo, Wei Li, Yuqing Zhao
Summary: The study focused on the ultrasound-assisted adsorption/desorption of licorice flavonoids (LFs) on HPD-100 resins, finding that higher ultrasonic power density and lower temperature enhanced the process. With an ultrasonic power density of 0.5 W/cm2, the recovery of LFs with ultrasonic treatment was 9.99% higher than without. Licochalcone A (LicA) had the highest adsorption capacities, while liquiritigenin showed the highest desorption capacities. The activities of LFs increased with the enhancement of ultrasonic power density, and they were found to have a protective effect on H9c2 cardiomyocytes.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Jie-Wei He, Ping Guo, Li Yang, Jun-Wei He
Summary: In this study, six compounds were isolated from the flowers of Hosta plantaginea, and compounds 1-4 showed significant inhibition on NO production in LPS-induced RAW 264.7 cells. Additionally, compounds 1 and 3 were found to reduce the levels of inflammatory factors and phosphorylation of NF-kB p65, suggesting their potential as anti-inflammatory candidates.
Article
Biochemistry & Molecular Biology
Sang Gu Kang, Gi Baek Lee, Ramachandran Vinayagam, Geum Sook Do, Se Yong Oh, Su Jin Yang, Jun Bum Kwon, Mahendra Singh
Summary: Quercetin (Qu), a plant polyphenol, can improve bioavailability in nanosuspensions, exhibiting antioxidant, anti-inflammatory, and antibacterial effects.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.