Recent advances in N-heterocyclic carbene catalyzed achiral synthesis

N-Heterocyclic Carbene Catalyzed γ-Dihalomethylenation of Enals by Single-Electron Transfer

(2016) Wen Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α-Fluoroallenoate Synthesis via N-Heterocyclic Carbene-Catalyzed Fluorination Reaction of Alkynals

(2016) Xu Wang et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Convenient Benzonitrile Assembly

(2016) Qianfa Jia et al.   ORGANIC LETTERS

N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

(2016) Fangyi Li et al.   Organic Chemistry Frontiers

N-Heterocyclic Carbene Catalyzed Synthesis of δ-Sultones via α,β-Unsaturated Sulfonyl Azolium Intermediates

(2015) Andrei Ungureanu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

N-Heterocyclic Carbene-Catalyzed δ-Carbon LUMO Activation of Unsaturated Aldehydes

(2015) Tingshun Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N -Heterocyclic carbene catalyzed tail-to-tail oligomerization of N , N -dimethylacrylamide (DMAA) and the search for the Stetter reaction of DMAA with benzaldehyde

(2015) Oue-artorn Rajachan et al.   TETRAHEDRON LETTERS

N-Heterocyclic carbene catalysed redox isomerisation of esters to functionalised benzaldehydes

(2015) Lisa Candish et al.   Chemical Science

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic-Carbene-Catalyzed Synthesis of 2-Aryl Indoles

(2014) M. Todd Hovey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cascade Olefin Isomerization/Intramolecular Diels-Alder Reaction Catalyzed by N-Heterocyclic Carbenes

(2014) Marcin Kowalczyk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters

(2014) Jun-Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon–sulfur bonds

(2014) Lin He et al.   CHEMICAL COMMUNICATIONS

Cooperative N-Heterocyclic Carbene/Brønsted Acid Catalysis for the Tail-to-Tail (Co)dimerization of Methacrylonitrile

(2014) Terumasa Kato et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective All-Carbon (4+2) Annulation by N-Heterocyclic Carbene Catalysis

(2014) Lisa Candish et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective N-Heterocyclic Carbene-Catalyzed Cross-Benzoin Reactions: Importance of the Fused Ring in Triazolium Salts

(2014) Steven M. Langdon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

N-Heterocyclic Carbene Catalyzed Umpolung of Styrenes: Mechanistic Elucidation and Selective Tail-to-Tail Dimerization

(2014) Michael Schedler et al.   ORGANIC LETTERS

N-Heterocyclic Carbene Catalyzed Intramolecular Acylation of Allylic Electrophiles

(2014) Ming Zhao et al.   ORGANIC LETTERS

Facile Synthesis of γ-Ketophosphonates by an Intermolecular Stetter Reaction onto Vinylphosphonates

(2014) Atanu Patra et al.   ORGANIC LETTERS

Metal and carbene organocatalytic relay activation of alkynes for stereoselective reactions

(2014) Kayambu Namitharan et al.   Nature Communications

Benzene construction via organocatalytic formal [3+3] cycloaddition reaction

(2014) Tingshun Zhu et al.   Nature Communications

NHC catalysed trimethylsilylation of terminal alkynes and indoles with Ruppert's reagent under solvent free conditions

(2014) Panjab Arde et al.   RSC Advances

N-heterocyclic carbene catalysed oxidative esterification of aliphatic aldehydes

(2014) Ramesh C. Samanta et al.   Organic Chemistry Frontiers

NHC-Catalyzed Hydroacylation of Styrenes

(2013) Michael Schedler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diaminocyclopropenylidene Organocatalysts: Beyond N-Heterocyclic Carbenes

(2013) Stephen J. Connon   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

Catalysis with N-Heterocyclic Carbenes under Oxidative Conditions

(2013) Suman De Sarkar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Divergent NHC-Catalyzed Oxidative Transformations of 3-Bromoenal: Selective Synthesis of 2H-Pyran-2-ones and Chiral Dihydropyranones

(2013) Gang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Experimental Mechanistic Studies of the Tail-to-Tail Dimerization of Methyl Methacrylate Catalyzed by N-Heterocyclic Carbene

(2013) Terumasa Kato et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Activation of Carbohydrates as Formaldehyde Equivalents for Stetter Reaction with Enones

(2013) Junmin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

(2013) Zhenqian Fu et al.   Nature Chemistry

An internal affair

(2013) Jeffrey W. Bode   Nature Chemistry

Catalytic MBH reaction of β-substituted nitroalkenes with azodicarboxylates

(2013) Xiang-Yu Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic Carbene-Catalyzed Cyclotetramerization of Acrylates

(2013) Shin-ichi Matsuoka et al.   ORGANIC LETTERS

Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals

(2013) Philip Wheeler et al.   Chemical Science

Exploiting Acyl and Enol Azolium Intermediates via N-Hetero- cyclic Carbene-Catalyzed Reactions of α-Reducible Aldehydes

(2012) Harit U. Vora et al.   ADVANCED SYNTHESIS & CATALYSIS

Conjugate-Addition Organopolymerization: Rapid Production of Acrylic Bioplastics by N-Heterocyclic Carbenes

(2012) Yuetao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of β,γ-Unsaturated α-Fluoroesters Catalyzed by N-Heterocyclic Carbenes

(2012) Yu-Ming Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Concise Assembly of Electron-Deficient 2,4-Dienes and 2,4-Dienals: Regio- and Stereoselectiveexo-Diels-Alder and Redox Reactions through Sequential Amine and Carbene Catalysis

(2012) Chao Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic-Carbene-Catalyzed Asymmetric Oxidative Hetero-Diels-Alder Reactions with Simple Aliphatic Aldehydes

(2012) Xiaodan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide

(2012) Kiyoun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-catalyzed thioesterification of aldehydes by external redox activation

(2012) Takuya Uno et al.   CHEMICAL COMMUNICATIONS

Non-asymmetric organocatalysis

(2012) Polyssena Renzi et al.   CHEMICAL COMMUNICATIONS

Asymmetric oxidative Lewis base catalysis—unifying iminium and enamine organocatalysis with oxidations

(2012) Magnus Rueping et al.   CHEMICAL COMMUNICATIONS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene-Catalyzed Ireland–Coates Claisen Rearrangement: Synthesis of Functionalized β-Lactones

(2012) Lisa Candish et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative γ-Addition of Enals to Trifluoromethyl Ketones: Enantioselectivity Control via Lewis Acid/N-Heterocyclic Carbene Cooperative Catalysis

(2012) Junming Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene catalyzed synthesis of oxime esters

(2012) Dieter Enders et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic Carbene-Catalyzed Internal Redox Reaction of Alkynals: An Efficient Synthesis of Allenoates

(2012) Yu-Ming Zhao et al.   ORGANIC LETTERS

Extending NHC-Catalysis: Coupling Aldehydes with Unconventional Reaction Partners

(2011) Akkattu T. Biju et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene Catalyzed Intramolecular Hydroacylation of Activated Alkynes: Synthesis of Chromones

(2011) Seenuvasan Vedachalam et al.   ADVANCED SYNTHESIS & CATALYSIS

Designing N-Heterocyclic Carbenes: Simultaneous Enhancement of Reactivity and Enantioselectivity in the Asymmetric Hydroacylation of Cyclopropenes

(2011) Fan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α,β-Unsaturated Acyl Azoliums from N-Heterocyclic Carbene Catalyzed Reactions: Observation and Mechanistic Investigation

(2011) Jessada Mahatthananchai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Asymmetric NHC-Catalyzed Hydroacylation of Unactivated Alkenes

(2011) Isabel Piel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Umpolung of Michael Acceptors for Intermolecular Reactions

(2011) Akkattu T. Biju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple Recipe for Sophisticated Cocktails: Organocatalytic One-Pot Reactions-Concept, Nomenclature, and Future Perspectives

(2011) Łukasz Albrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

Computational Mechanistic Study of PMe3andN-Heterocyclic Carbene Catalyzed Intramolecular Morita−Baylis−Hillman-Like Cycloalkylations: The Origins of the Different Reactivity

(2011) Lili Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene-Catalyzed (4 + 2) Cycloaddition/Decarboxylation of Silyl Dienol Ethers with α,β-Unsaturated Acid Fluorides

(2011) Sarah J. Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes

(2011) Xavier Bugaut et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: a facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles

(2011) Shravankumar Kankala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

(2011) Sun Min Kim et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones

(2011) Olga Bortolini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-Catalyzed Oxidative Cyclization Reactions of 2-Alkynylbenzaldehydes under Aerobic Conditions: Synthesis of O-Heterocycles

(2011) Jong Hyub Park et al.   ORGANIC LETTERS

On the Role of CO2in NHC-Catalyzed Oxidation of Aldehydes

(2011) Pei-Chen Chiang et al.   ORGANIC LETTERS

Efficient Synthesis of Benzofuranones: N-Heterocyclic Carbene (NHC)/Base-Catalyzed Hydroacylation–Stetter–Rearrangement Cascade

(2011) Mohan Padmanaban et al.   ORGANIC LETTERS

Organocatalytic Tail-to-Tail Dimerization of Olefin: Umpolung of Methyl Methacrylate Mediated by N-Heterocyclic Carbene

(2011) Shin-ichi Matsuoka et al.   ORGANIC LETTERS

N-heterocyclic carbene-catalyzed rearrangements of vinyl sulfones

(2011) Roxanne L. Atienza et al.   Chemical Science

Cooperative Lewis acid/N-heterocyclic carbene catalysis

(2011) Daniel T. Cohen et al.   Chemical Science

N-heterocyclic carbene cascade catalysis: Dual Brønsted/Lewis base rearrangement of cyclopropyl enol esters to dihydropyranones

(2011) Lisa Candish et al.   Chemical Science

Intermolecular N-Heterocyclic Carbene Catalyzed Hydroacylation of Arynes

(2010) Akkattu T. Biju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes by Redox Activation

(2010) Suman De Sarkar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alane-Based Classical and Frustrated Lewis Pairs in Polymer Synthesis: Rapid Polymerization of MMA and Naturally Renewable Methylene Butyrolactones into High-Molecular-Weight Polymers

(2010) Yuetao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes

(2010) Nadine Kuhl et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Domino Michael-Henry Reaction: Enantioselective Access to Bicycles with Consecutive Quaternary Centers by Using Bifunctional Catalysts

(2010) Magnus Rueping et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene Catalyzed Asymmetric Hydration: Direct Synthesis of α-Protio and α-Deuterio α-Chloro and α-Fluoro Carboxylic Acids

(2010) Harit U. Vora et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Conjugate Additions of Alcohols

(2010) Eric M. Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Cascade Reaction Involving the Hydroacylation of Unactivated Alkynes

(2010) Akkattu T. Biju et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NHC Catalyzed Oxidations of Aldehydes to Esters: Chemoselective Acylation of Alcohols in Presence of Amines

(2010) Suman De Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

NHC-Catalyzed Intramolecular Redox Amidation for the Synthesis of Functionalized Lactams

(2010) Karen Thai et al.   ORGANIC LETTERS

NHC-Catalyzed Spiro Bis-Indane Formation via Domino Stetter−Aldol−Michael and Stetter−Aldol−Aldol Reactions

(2010) Eduardo Sánchez-Larios et al.   ORGANIC LETTERS

Oxidative Amidation and Azidation of Aldehydes by NHC Catalysis

(2010) Suman De Sarkar et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aromatic Aldehydes with Activated Alkyl Halides

(2010) Mohan Padmanaban et al.   ORGANIC LETTERS

The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones

(2010) Lu Lin et al.   TETRAHEDRON LETTERS

Nucleophilic acylation of α-haloketones with aldehydes: an umpolung strategy for the synthesis of 1,3-diketones

(2010) Santosh Singh et al.   TETRAHEDRON LETTERS

A Direct Intermolecular Cross-Benzoin Type Reaction: N-Heterocyclic Carbene-Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones

(2009) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

Conversion of Carbon Dioxide into Methanol with Silanes over N-Heterocyclic Carbene Catalysts

(2009) Siti Nurhanna Riduan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective Synthesis of 2,6-cis-Tetrahydropyrans through a Tandem Allylic Oxidation/Oxa-Michael Reaction Promoted by thegem-Disubstituent Effect: Synthesis of (+)-Neopeltolide Macrolactone

(2009) Hyoungsu Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Organocatalytic Domino Michael/Aldol Reactions: Enantioselective Synthesis of Chiral Cycloheptanones, Tetrahydrochromenones, and Polyfunctionalized Bicyclo[3.2.1]octanes

(2009) Magnus Rueping et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic amide formation with α′-hydroxyenones as acylating reagents

(2009) Pei-Chen Chiang et al.   CHEMICAL COMMUNICATIONS

Organocatalysis—after the gold rush

(2009) Søren Bertelsen et al.   CHEMICAL SOCIETY REVIEWS

Diastereoselective Synthesis of Indanes via a Domino Stetter−Michael Reaction

(2009) Eduardo Sánchez-Larios et al.   JOURNAL OF ORGANIC CHEMISTRY

An Efficient Carbene-Catalyzed Access to 3,4-Dihydrocoumarins

(2009) Kirsten Zeitler et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalysis in Organic Synthesis

(2009) Louis S. Hegedus   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Generation of α,β-Unsaturated Acyl Imidazoliums: Synthesis of Dihydropyranones by their Reaction with Enolates

(2009) Sarah J. Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Hydroacylation of Unactivated Double Bonds

(2009) Keiichi Hirano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NHC-Catalyzed Ring Expansion of Oxacycloalkane-2-carboxaldehydes: A Versatile Synthesis of Lactones

(2009) Li Wang et al.   ORGANIC LETTERS

Impact of Solvent Polarity on N-Heterocyclic Carbene-Catalyzed β-Protonations of Homoenolate Equivalents

(2009) Brooks E. Maki et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Intramolecular Aldehyde−Nitrile Cross Coupling: An Easy Access to 3- Aminochromones†

(2009) Seenuvasan Vedachalam et al.   ORGANIC LETTERS

Diastereoselective Synthesis of Trifluoromethylated γ-Butyrolactonesvia N-Heterocyclic Carbene-Catalyzed Conjugated Umpolung of α,β-Unsaturated Aldehydes

(2008) Keiichi Hirano et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Organocatalysis: From Infancy to Adolescence

(2008) Alessandro Dondoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomimetic Carbene-Catalyzed Oxidations of Aldehydes Using TEMPO

(2008) Joyram Guin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in carbon–carbon bond-forming reactions involving homoenolates generated by NHC catalysis

(2008) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene-Catalyzed Nucleophilic Aroylation of Fluorobenzenes

(2008) Yumiko Suzuki et al.   JOURNAL OF ORGANIC CHEMISTRY

Cyclic Ketimines as Superior Electrophiles for NHC-Catalyzed Homoenolate Additions with Broad Scope and Low Catalyst Loadings

(2008) Michael Rommel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orthogonal Synthesis of Indolines and Isoquinolines via Aryne Annulation

(2008) Christopher D. Gilmore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Amination of Homoenolates Catalyzed byN-Heterocyclic Carbenes

(2008) Audrey Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Oxidation of Unactivated Aldehydes to Esters

(2008) Brooks E. Maki et al.   ORGANIC LETTERS

Nucleophilic carbene-catalysed oxidative esterification reactions

(2008) Conor Noonan et al.   TETRAHEDRON LETTERS