CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse

(2017) Sabine Ruehle et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

Functional selectivity of GPCR-directed drug action through location bias

(2017) Roshanak Irannejad et al.   Nature Chemical Biology

Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling

(2017) Stephanie C. Gantz et al.   NEURON

The CB1 Receptor as the Cornerstone of Exostasis

(2017) Pier Vincenzo Piazza et al.   NEURON

Effects of tetrahydrocannabinol on glucose uptake in the rat brain

(2017) I. Miederer et al.   NEUROPHARMACOLOGY

Synaptic functions of endocannabinoid signaling in health and disease

(2017) Alfonso Araque et al.   NEUROPHARMACOLOGY

Pregnenolone does not interfere with the effects of cannabinoids on synaptic transmission in the cerebellum and the nucleus accumbens

(2017) Anna Krohmer et al.   PHARMACOLOGICAL RESEARCH

An Introduction to the Endogenous Cannabinoid System

(2016) Hui-Chen Lu et al.   BIOLOGICAL PSYCHIATRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling

(2016) Carolina Inda et al.   JOURNAL OF CELL BIOLOGY

Cannabinoid Receptor Interacting Protein 1a Competition with β -Arrestin for CB 1 Receptor Binding Sites

(2016) Lawrence C. Blume et al.   MOLECULAR PHARMACOLOGY

The effects of Δ9-tetrahydrocannabinol on the dopamine system

(2016) Michael A. P. Bloomfield et al.   NATURE

A cannabinoid link between mitochondria and memory

(2016) Etienne Hebert-Chatelain et al.   NATURE

The Hyperpolarization-Activated Cation Current I h : The Missing Link Connecting Cannabinoids to Cognition

(2016) Geoffrey A. Vargish et al.   NEURON

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

(2016) Thomas J. Younts et al.   NEURON

Cannabinoid Control of Learning and Memory through HCN Channels

(2016) Mattia Maroso et al.   NEURON

Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent

(2016) Rene Nahum Caballero-Florán et al.   NEUROPHARMACOLOGY

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse

(2016) J.F. Oliveira da Cruz et al.   NEUROSCIENCE

Gβγ subunits—Different spaces, different faces

(2016) Shahriar M. Khan et al.   PHARMACOLOGICAL RESEARCH

Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation

(2016) Arnau Busquets-Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells

(2016) Loïs S Miraucourt et al.   eLife

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

(2016) Gemma Navarro et al.   Frontiers in Neuroscience

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex

(2016) Rebeca Diez-Alarcia et al.   Frontiers in Pharmacology

Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration

(2016) Juan Mendizabal-Zubiaga et al.   Frontiers in Physiology

Dissecting the cannabinergic control of behavior: Thewherematters

(2015) Arnau Busquets-Garcia et al.   BIOESSAYS

Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus

(2015) Stephan Guggenhuber et al.   Brain Structure & Function

G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes

(2015) Nikoleta G. Tsvetanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VGluT3-Expressing CCK-Positive Basket Cells Construct Invaginating Synapses Enriched with Endocannabinoid Signaling Proteins in Particular Cortical and Cortex-Like Amygdaloid Regions of Mouse Brains

(2015) Y. Omiya et al.   JOURNAL OF NEUROSCIENCE

Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release

(2015) S.-H. Lee et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Habenular CB1 Receptors Control the Expression of Aversive Memories

(2015) Edgar Soria-Gómez et al.   NEURON

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes

(2015) Sébastien Sultan et al.   NEURON

Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla

(2015) Stefanie C. Hofer et al.   NEUROPHARMACOLOGY

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

(2015) R. Martin et al.   SCIENCE

Mitochondrial synapses: intracellular communication and signal integration

(2015) Martin Picard   TRENDS IN NEUROSCIENCES

Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability

(2015) Martin Häring et al.   Frontiers in Behavioral Neuroscience

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

(2015) Xavier Viñals et al.   PLOS BIOLOGY

Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

(2014) Clemens Steegborn   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endocannabinoids Induce Lateral Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission

(2014) Marta Gómez-Gonzalo et al.   CEREBRAL CORTEX

Rising stars: Modulation of brain functions by astroglial type-1 cannabinoid receptors

(2014) Mathilde Metna-Laurent et al.   GLIA

Experience Salience Gates Endocannabinoid Signaling at Hypothalamic Synapses

(2014) J. I. Wamsteeker Cusulin et al.   JOURNAL OF NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Pregnenolone Can Protect the Brain from Cannabis Intoxication

(2014) Monique Vallée et al.   SCIENCE

Toward the Development of Bivalent Ligand Probes of Cannabinoid CB1 and Orexin OX1 Receptor Heterodimers

(2014) David A. Perrey et al.   ACS Medicinal Chemistry Letters

Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission

(2014) Michael V. Accardi et al.   Nature Communications

Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor

(2014) Etienne Hebert-Chatelain et al.   Molecular Metabolism

Endogenous lipid activated G protein-coupled receptors: Emerging structural features from crystallography and molecular dynamics simulations

(2013) Dow P. Hurst et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Co-expression of the human cannabinoid receptor coding region splice variants (hCB1) affects the function of hCB1 receptor complexes

(2013) Amina M. Bagher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delineation of Domains Within the Cannabinoid CB1 and Dopamine D2 Receptors That Mediate the Formation of the Heterodimer Complex

(2013) Shazina S. Khan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus

(2013) Frauke Steindel et al.   JOURNAL OF NEUROCHEMISTRY

CA1 Pyramidal Cell Theta-Burst Firing Triggers Endocannabinoid-Mediated Long-Term Depression at Both Somatic and Dendritic Inhibitory Synapses

(2013) T. J. Younts et al.   JOURNAL OF NEUROSCIENCE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes

(2013) Barbara Bosier et al.   Molecular Metabolism

Multiple Functions of Endocannabinoid Signaling in the Brain

(2012) István Katona et al.   Annual Review of Neuroscience

Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD

(2012) Jing Han et al.   CELL

Activation-Dependent Subcellular Distribution Patterns of CB1 Cannabinoid Receptors in the Rat Forebrain

(2012) Karine Thibault et al.   CEREBRAL CORTEX

Cannabinoid Receptors CB1and CB2Form Functional Heteromers in Brain

(2012) Lucía Callén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1Receptors

(2012) Mark Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors

(2012) W. Xiong et al.   JOURNAL OF NEUROSCIENCE

Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors

(2012) M. Metna-Laurent et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial CB1 receptors regulate neuronal energy metabolism

(2012) Giovanni Bénard et al.   NATURE NEUROSCIENCE

Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

(2012) Rogier Min et al.   NATURE NEUROSCIENCE

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Genetic Dissection of the Role of Cannabinoid Type-1 Receptors in the Emotional Consequences of Repeated Social Stress in Mice

(2012) Sarah Dubreucq et al.   NEUROPSYCHOPHARMACOLOGY

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission

(2012) Alejandro Aparisi Rey et al.   NEUROPSYCHOPHARMACOLOGY

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones

(2011) Alex Straiker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity

(2011) Emmanuel S Onaivi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Polymodal activation of the endocannabinoid system in the extended amygdala

(2011) Nagore Puente et al.   NATURE NEUROSCIENCE

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

(2011) Antonio Ortega-Alvaro et al.   NEUROPSYCHOPHARMACOLOGY

The major central endocannabinoid directly acts at GABAA receptors

(2011) E. Sigel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus

(2011) T. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Signaling

(2011) M. Laplante et al.   Cold Spring Harbor Perspectives in Biology

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Mitochondria and Neuroplasticity

(2010) Aiwu Cheng et al.   ASN Neuro

Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?

(2010) Tricia H Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endocannabinoid Binding to the Cannabinoid Receptors: What Is Known and What Remains Unknown

(2010) Patricia Reggio   CURRENT MEDICINAL CHEMISTRY

A synaptocentric view of the neuroendocrine response to stress

(2010) Jaclyn I. Wamsteeker et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor

(2010) Dow P. Hurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repeated Stress Impairs Endocannabinoid Signaling in the Paraventricular Nucleus of the Hypothalamus

(2010) J. I. Wamsteeker et al.   JOURNAL OF NEUROSCIENCE

Synaptic activation of kainate receptors gates presynaptic CB1 signaling at GABAergic synapses

(2010) Joana Lourenço et al.   NATURE NEUROSCIENCE

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

(2010) Andrés E Chávez et al.   NATURE NEUROSCIENCE

Bimodal control of stimulated food intake by the endocannabinoid system

(2010) Luigi Bellocchio et al.   NATURE NEUROSCIENCE

Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

(2010) Marta Navarrete et al.   NEURON

Human Sperm Anatomy: Ultrastructural Localization of the Cannabinoid1 Receptor and a Potential Role of Anandamide in Sperm Survival and Acrosome Reaction

(2009) Saveria Aquila et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

G protein-coupled receptors: the inside story

(2009) Kees Jalink et al.   BIOESSAYS

Location, Structure, and Dynamics of the Synthetic Cannabinoid Ligand CP-55,940 in Lipid Bilayers

(2009) Tomohiro Kimura et al.   BIOPHYSICAL JOURNAL

Signal transduction of the CB1 cannabinoid receptor

(2009) Gábor Turu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Ligand- and Heterodimer-Directed Signaling of the CB1 Cannabinoid Receptor

(2009) B. D. Hudson et al.   MOLECULAR PHARMACOLOGY

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

(2009) Emma Puighermanal et al.   NATURE NEUROSCIENCE

Self-modulation of neocortical pyramidal neurons by endocannabinoids

(2009) Silvia Marinelli et al.   NATURE NEUROSCIENCE

Metaplasticity of Hypothalamic Synapses following In Vivo Challenge

(2009) J. Brent Kuzmiski et al.   NEURON

Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system

(2009) Pauline Lafenêtre et al.   NEUROPHARMACOLOGY

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3

(2008) Raphael Rozenfeld et al.   FASEB JOURNAL

CB1cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes

(2008) Susana Mato et al.   GLIA

μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB1 Receptor: Electrophysiological and FRET Assay Analysis

(2008) Minoru Hojo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Role of CB2 receptors in neuroprotective effects of cannabinoids

(2008) Javier Fernández-Ruiz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

Endocannabinoids Mediate Neuron-Astrocyte Communication

(2008) Marta Navarrete et al.   NEURON

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Altered surface trafficking of presynaptic cannabinoid type 1 receptor in and out synaptic terminals parallels receptor desensitization

(2008) L. Mikasova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

(2008) B. D. Heifets et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA