The Contribution of Necroptosis in Neurodegenerative Diseases

Is Necroptosis a Death Pathway in Aluminum-Induced Neuroblastoma Cell Demise?

(2017) Q.L. Zhang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

(2016) Katharina Rohde et al.   CELL DEATH AND DIFFERENTIATION

Palmitoylation of caspase-6 by HIP14 regulates its activation

(2016) Niels H Skotte et al.   CELL DEATH AND DIFFERENTIATION

Developmental checkpoints guarded by regulated necrosis

(2016) Christopher P. Dillon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Necrosome core machinery: MLKL

(2016) Jing Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulated cell death and adaptive stress responses

(2016) Lorenzo Galluzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy

(2016) Deyan Kong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Axonal Degeneration: RIPK1 Multitasking in ALS

(2016) Kristin Politi et al.   CURRENT BIOLOGY

Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors

(2016) Andrea Barabino et al.   DEVELOPMENT

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain

(2016) Yi Qu et al.   EXPERIMENTAL NEUROLOGY

Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation

(2016) Filip Petković et al.   GLIA

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

(2016) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation

(2016) Takeshi Funakoshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury

(2016) Shihong Wen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Walking the tightrope: proteostasis and neurodegenerative disease

(2016) Justin J. Yerbury et al.   JOURNAL OF NEUROCHEMISTRY

Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43

(2016) Mathieu Meessen-Pinard et al.   JOURNAL OF VIROLOGY

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Upregulation of PSMB4 is Associated with the Necroptosis after Spinal Cord Injury

(2016) Chunshuai Wu et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effect of NecroX-5 against retinal degeneration in rodents

(2016) Hyung Il Kim et al.   NEUROREPORT

β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38MAPK–p53 Signaling Pathway

(2016) Zhi Pan et al.   NEUROTOXICITY RESEARCH

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion

(2016) Jeong-Min Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Necroptosis contributes to methamphetamine-induced cytotoxicity in rat cortical neurons

(2016) Kun Xiong et al.   TOXICOLOGY IN VITRO

Post-translational modifications as key regulators of TNF-induced necroptosis

(2016) X Liu et al.   Cell Death & Disease

Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target

(2016) A Cougnoux et al.   Cell Death & Disease

Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis

(2016) Robert W. Button et al.   Oncotarget

Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells

(2016) Xue‑tao Li et al.   Oncotarget

Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells

(2016) Jaydeep Bhat et al.   Oncotarget

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells

(2016) Feiyan Liu et al.   Oncotarget

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

(2016) Tao Liu et al.   Scientific Reports

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

(2016) Wei Lu et al.   PLoS One

RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss and Chronic Kidney Disease Progression in Rats

(2016) Yongjun Zhu et al.   PLoS One

RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF

(2016) Yang Xu et al.   Scientific Reports

Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway

(2015) Xin Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells

(2015) Sofie Steinwascher et al.   CANCER LETTERS

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain

(2015) Claire Thornton et al.   CLINICA CHIMICA ACTA

Death in the fast lane: what's next for necroptosis?

(2015) Andrew Oberst   FEBS Journal

New aspects of 24( S )-hydroxycholesterol in modulating neuronal cell death

(2015) Noriko Noguchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway

(2015) Qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RIP1 Inhibition Rescues from LPS-Induced RIP3-Mediated Programmed Cell Death, Distributed Energy Metabolism and Spatial Memory Impairment

(2015) Sara Nikseresht et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway

(2015) Dominique Bollino et al.   JOURNAL OF NEUROCHEMISTRY

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

Oligogenic inheritance of optineurin (OPTN) andC9ORF72mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions ofC9ORF72-ALS

(2015) Joanna J. Bury et al.   NEUROPATHOLOGY

Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury

(2015) H. Fan et al.   NEUROSCIENCE

Transcriptional dysregulation in Huntington’s disease: The role of histone deacetylases

(2015) Sorabh Sharma et al.   PHARMACOLOGICAL RESEARCH

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Sorafenib-induced defective autophagy promotes cell death by necroptosis

(2015) Pedram Kharaziha et al.   Oncotarget

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Diverse functions of 24(S)-hydroxycholesterol in the brain

(2014) Noriko Noguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Akt and Mammalian Target of Rapamycin in Functional Outcome after Concussive Brain Injury in Mice

(2014) Xiaoxia Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Motor Neuron Death in ALS: Programmed by Astrocytes?

(2014) Sheila K. Pirooznia et al.   NEURON

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state

(2014) D. Jantas et al.   NEUROPHARMACOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways

(2013) Di Wang et al.   APOPTOSIS

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Inhibition of ERK Activation Mediates the Protection of Necrostatin-1 on Glutamate Toxicity in HT-22 Cells

(2013) Min Zhang et al.   NEUROTOXICITY RESEARCH

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

(2013) Johanna Viiri et al.   PLoS One

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Multifaceted deaths orchestrated by mitochondria in neurones

(2009) Phillip Nagley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necroptosis: A Specialized Pathway of Programmed Necrosis

(2008) Lorenzo Galluzzi et al.   CELL

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin-mediated regulation of TNFR1 signaling

(2008) Ingrid E. Wertz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA