The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways

Autophagy plays a protective role during zVAD-induced necrotic cell death

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The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Autophagy is a survival force via suppression of necrotic cell death

(2012) Han-Ming Shen et al.   EXPERIMENTAL CELL RESEARCH

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Neuroprotective effects of valproic acid following transient global ischemia in rats

(2012) Aiguo Xuan et al.   LIFE SCIENCES

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

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Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation

(2011) Szu-Ying Chen et al.   Autophagy

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

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TNFα-Induced Necroptosis and Autophagy via Supression of the p38–NF-κB Survival Pathway in L929 Cells

(2011) Yuan-Chao Ye et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

The Ripoptosome: Death Decision in the Cytosol

(2011) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Ripped to death

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Ripoptosome: a novel IAP-regulated cell death-signalling platform

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TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

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Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma

(2010) Yuan-Ling Liu et al.   Autophagy

Necroptosis as an alternative form of programmed cell death

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The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy

(2010) Erik R. Sampson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Valproate Administered after Traumatic Brain Injury Provides Neuroprotection and Improves Cognitive Function in Rats

(2010) Pramod K. Dash et al.   PLoS One

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

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High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo

(2009) Annika Lehmann et al.   BMC CANCER

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines

(2009) Melissa J LaBonte et al.   BMC Medical Genomics

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

NEMO/IKKγ regulates an early NF-κB-independent cell-death checkpoint during TNF signaling

(2009) D Legarda-Addison et al.   CELL DEATH AND DIFFERENTIATION

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo

(2009) Giuseppe Faraco et al.   NEUROBIOLOGY OF DISEASE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Necroptosis: A Specialized Pathway of Programmed Necrosis

(2008) Lorenzo Galluzzi et al.   CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

TNFα and reactive oxygen species in necrotic cell death

(2008) Michael J Morgan et al.   CELL RESEARCH

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor κB

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