RIP1 Inhibition Rescues from LPS-Induced RIP3-Mediated Programmed Cell Death, Distributed Energy Metabolism and Spatial Memory Impairment

Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury

(2014) Y. Wang et al.   NEUROSCIENCE

Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice

(2014) Yue Hou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fingolimod affects gene expression profile associated with LPS-induced memory impairment

(2014) Rana Omidbakhsh et al.   EXPERIMENTAL BRAIN RESEARCH

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

Mevalonate Kinase Deficiency and Neuroinflammation: Balance between Apoptosis and Pyroptosis

(2013) Paola Tricarico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

(2013) Michael Fricker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Necroptosis Chemical Necrostatin-1 Can Also Suppress Apoptotic and Autophagic Pathway to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model

(2013) Pan Chang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice

(2013) Yingqun Zhou et al.   MEDIATORS OF INFLAMMATION

Molecular Basis of Etiological Implications in Alzheimer’s Disease: Focus on Neuroinflammation

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia

(2013) S J Kim et al.   Cell Death & Disease

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia–reperfusion in vivo

(2012) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

Signal transduction by tumor necrosis factor receptors

(2012) Lucía Cabal-Hierro et al.   CELLULAR SIGNALLING

Nec-1 Enhances Shikonin-Induced Apoptosis in Leukemia Cells by Inhibition of RIP-1 and ERK1/2

(2012) Weidong Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protease Activity of Procaspase-8 Is Essential for Cell Survival by Inhibiting Both Apoptotic and Nonapoptotic Cell Death Dependent on Receptor-interacting Protein Kinase 1 (RIP1) and RIP3

(2012) Mina Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Death receptor signalling in central nervous system inflammation and demyelination

(2011) Conor Mc Guire et al.   TRENDS IN NEUROSCIENCES

S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats

(2010) Qi-Hai Gong et al.   BRAIN BEHAVIOR AND IMMUNITY

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

(2010) Frances J Northington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice

(2010) Ryoichi Kimura et al.   JOURNAL OF NEUROCHEMISTRY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

(2009) Weidong Han et al.   APOPTOSIS

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

(2009) Daniel M. Rosenbaum et al.   JOURNAL OF NEUROSCIENCE RESEARCH

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents

(2008) Takashi Iwai et al.   NEUROSCIENCE RESEARCH