Palmitoylation of caspase-6 by HIP14 regulates its activation

C-Terminal Cleavage of the Amyloid-β Protein Precursor at Asp664: A Switch Associated with Alzheimer's Disease

(2017) Surita Banwait et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits

(2015) Israel Aharony et al.   HUMAN MOLECULAR GENETICS

In Silico Identification of Protein S-Palmitoylation Sites and Their Involvement in Human Inherited Disease

(2015) Shuyan Li et al.   Journal of Chemical Information and Modeling

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

(2015) Bibiana K.Y. Wong et al.   NEUROBIOLOGY OF DISEASE

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

(2015) Shaun S. Sanders et al.   PLoS Computational Biology

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

(2014) Stefanie L. Butland et al.   HUMAN MOLECULAR GENETICS

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-6 as a novel early target in the treatment of Alzheimer's disease

(2013) Andrea C. LeBlanc   EUROPEAN JOURNAL OF NEUROSCIENCE

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

(2013) Dagmar E. Ehrnhoefer et al.   HUMAN MOLECULAR GENETICS

Forcefield_PTM: Ab Initio Charge and AMBER Forcefield Parameters for Frequently Occurring Post-Translational Modifications

(2013) George A. Khoury et al.   Journal of Chemical Theory and Computation

Specific Inhibition of Caspase-3 by a Competitive DARPin: Molecular Mimicry between Native and Designed Inhibitors

(2013) Thilo Schroeder et al.   STRUCTURE

An Optimized Activity-Based Probe for the Study of Caspase-6 Activation

(2012) Laura E. Edgington et al.   CHEMISTRY & BIOLOGY

Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease

(2012) Liza M. Sutton et al.   HUMAN MOLECULAR GENETICS

Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the Same Effect on Inhibition of Apoptosis

(2012) Zhe-Min Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin

(2012) E. Waldron-Roby et al.   JOURNAL OF NEUROSCIENCE

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

(2012) Karen Stanger et al.   Nature Chemical Biology

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

(2012) Christopher E. Heise et al.   PLoS One

Phosphorylation Regulates Assembly of the Caspase-6 Substrate-Binding Groove

(2012) Elih M. Velázquez-Delgado et al.   STRUCTURE

Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation

(2011) Ilka Müller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

(2011) R. R. Singaraja et al.   HUMAN MOLECULAR GENETICS

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14

(2011) Kun Huang et al.   HUMAN MOLECULAR GENETICS

Ion Channel Regulation by Protein Palmitoylation

(2011) Michael J. Shipston   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Apo-Caspase-6 Crystal Form Reveals the Active Conformation of the Apoenzyme

(2011) Ilka Müller et al.   JOURNAL OF MOLECULAR BIOLOGY

Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-Dependent Axon/Neuron Loss and Improves Neurological Function after Stroke

(2011) N. Akpan et al.   JOURNAL OF NEUROSCIENCE

Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

(2011) Jeffrey B Carroll et al.   MOLECULAR THERAPY

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

(2011) Dagmar E. Ehrnhoefer et al.   PLoS One

Caspase-6 and neurodegeneration

(2011) Rona K. Graham et al.   TRENDS IN NEUROSCIENCES

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

(2010) Xiao-Jun Wang et al.   EMBO REPORTS

Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A

(2010) Andrea W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

(2010) Sravanti Vaidya et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

(2010) M. Metzler et al.   JOURNAL OF NEUROSCIENCE

Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

(2010) R. K. Graham et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

(2010) Katya J Park et al.   NATURE NEUROSCIENCE

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease

(2009) Andreas Weiss et al.   ANALYTICAL BIOCHEMISTRY

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience

(2009) Junli Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

The crystal structure of caspase-6, a selective effector of axonal degeneration

(2009) Renato Baumgartner et al.   BIOCHEMICAL JOURNAL

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin

(2009) M. A. Pouladi et al.   BRAIN

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway

(2009) S Inoue et al.   CELL DEATH AND DIFFERENTIATION

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function

(2009) Roshni R. Singaraja et al.   CIRCULATION RESEARCH

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

(2009) Kun Huang et al.   FASEB JOURNAL

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

(2009) Sarah J Tabrizi et al.   LANCET NEUROLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664

(2008) Veronica Galvan et al.   BEHAVIOURAL BRAIN RESEARCH

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

(2008) Guy Klaiman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

(2008) Simon C. Warby et al.   HUMAN MOLECULAR GENETICS

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

(2008) Haipeng Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer Disease Aβ Production in the Absence ofS-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

(2008) Kulandaivelu S. Vetrivel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY