The emerging field of epigenetics in neurodegeneration and neuroprotection

MicroRNA epigenetic signatures in human disease

(2016) Klara Piletič et al.   ARCHIVES OF TOXICOLOGY

Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics

(2016) Bisrat T. Woldemichael et al.   BIOCHEMICAL PHARMACOLOGY

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

(2016) K J Falkenberg et al.   CELL DEATH AND DIFFERENTIATION

Challenges in the analysis of long noncoding RNA functionality

(2016) Sergio Leone et al.   FEBS LETTERS

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

(2016) Melanie von Schimmelmann et al.   NATURE NEUROSCIENCE

Epigenome-wide Association Studies and the Interpretation of Disease -Omics

(2016) Ewan Birney et al.   PLoS Genetics

DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics

(2015) Jeremy J. Day et al.   Annual Review of Pharmacology and Toxicology

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

(2015) L. Formisano et al.   JOURNAL OF NEUROSCIENCE

Association of Single-Nucleotide Polymorphism in ANK1 with Late-Onset Alzheimer’s Disease in Han Chinese

(2015) Song Chi et al.   MOLECULAR NEUROBIOLOGY

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

(2015) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

(2015) Ian Maze et al.   NEURON

Promoting brain remodeling to aid in stroke recovery

(2015) Zheng Gang Zhang et al.   TRENDS IN MOLECULAR MEDICINE

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

(2015) Arshan Perera et al.   Cell Reports

DNA Methylation Inhibitor Zebularine Confers Stroke Protection in Ischemic Rats

(2015) Hua Dock et al.   Translational Stroke Research

The Gene Silencing Transcription Factor REST Represses miR-132 Expression in Hippocampal Neurons Destined to Die

(2014) Jee-Yeon Hwang et al.   JOURNAL OF MOLECULAR BIOLOGY

Casein Kinase 1 Suppresses Activation of REST in Insulted Hippocampal Neurons and Halts Ischemia-Induced Neuronal Death

(2014) N. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Histone H2A.Z subunit exchange controls consolidation of recent and remote memory

(2014) Iva B. Zovkic et al.   NATURE

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

Repressor element-1 silencing transcription factor (REST) is present in human control and Huntington's disease neurones

(2014) Davide Schiffer et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

MicroRNAs and synaptic plasticity--a mutual relationship

(2014) A. Aksoy-Aksel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease

(2014) T. C. Roberts et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation

(2014) Edmund Nesti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

Phenylbutyrate is a Multifaceted Drug that Exerts Neuroprotective Effects and Reverses the Alzheimer´s Disease-like Phenotype of a Commonly Used Mouse Model

(2013) Mar Cuadrado-Tejedor et al.   CURRENT PHARMACEUTICAL DESIGN

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

(2013) Fengli Wang et al.   HUMAN MOLECULAR GENETICS

Oral Administration of Histone Deacetylase Inhibitor MS-275 Ameliorates Neuroinflammation and Cerebral Amyloidosis and Improves Behavior in a Mouse Model

(2013) Zhi-Yuan Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

MicroRNAs in Cerebral Ischemia-Induced Neurogenesis

(2013) Xian Shuang Liu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCPE3 Ligase

(2013) Hao Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

The epigenetics pipeline

(2013) Vivian A. DeWoskin et al.   NATURE REVIEWS DRUG DISCOVERY

The Emerging Field of Neuroepigenetics

(2013) J. David Sweatt   NEURON

TET1 Controls CNS 5-Methylcytosine Hydroxylation, Active DNA Demethylation, Gene Transcription, and Memory Formation

(2013) Garrett A. Kaas et al.   NEURON

In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice

(2012) P Conforti et al.   GENE THERAPY

Neuroprotective effects of valproic acid following transient global ischemia in rats

(2012) Aiguo Xuan et al.   LIFE SCIENCES

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP

(2012) Mei Yu et al.   NEUROBIOLOGY OF AGING

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

(2012) Annamaria Lanzillotta et al.   NEUROBIOLOGY OF DISEASE

NCX1 is a new rest target gene: Role in cerebral ischemia

(2012) Luigi Formisano et al.   NEUROBIOLOGY OF DISEASE

Epigenetic Mechanisms in Stroke and Epilepsy

(2012) Jee-Yeon Hwang et al.   NEUROPSYCHOPHARMACOLOGY

Valproic acid increases white matter repair and neurogenesis after stroke

(2012) X.S. Liu et al.   NEUROSCIENCE

Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death

(2012) K.-M. Noh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

(2012) Constantin d'Ydewalle et al.   TRAFFIC

Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCFβ-TRCP in neuroblastoma cells

(2011) Akanksha Singh et al.   CANCER

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

microRNAs in neurons: manifold regulatory roles at the synapse

(2011) Gabriele Siegel et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

OPERating ON Chromatin, a Colorful Language where Context Matters

(2011) Kathryn E. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells

(2011) Zhi Huang et al.   NATURE CELL BIOLOGY

Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease

(2011) Chi-Tso Chiu et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

MicroRNA Profiling in Subventricular Zone after Stroke: MiR-124a Regulates Proliferation of Neural Progenitor Cells through Notch Signaling Pathway

(2011) Xian Shuang Liu et al.   PLoS One

Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia

(2011) Selva Baltan et al.   Translational Stroke Research

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Casein kinase 1: Complexity in the family

(2010) Jit Kong Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ischemic Preconditioning Regulates Expression of microRNAs and a Predicted Target, MeCP2, in Mouse Cortex

(2010) Theresa A Lusardi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition

(2010) Zhifei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator

(2010) Dimitrios Lagos et al.   NATURE CELL BIOLOGY

DNA methylation and memory formation

(2010) Jeremy J Day et al.   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

(2010) Noel J. Buckley et al.   NEUROBIOLOGY OF DISEASE

Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease

(2010) Tyisha Hathorn et al.   NEUROBIOLOGY OF DISEASE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions

(2010) J. J. Abrajano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

(2010) M. Stapels et al.   Science Signaling

Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb

(2010) R. S. Zukin   Science Signaling

Epigenetic influences on brain development and plasticity

(2009) Michela Fagiolini et al.   CURRENT OPINION IN NEUROBIOLOGY

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

(2009) Hyeon Ju Kim et al.   JOURNAL OF NEUROCHEMISTRY

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

The Polycomb Group Gene Bmi1 Regulates Antioxidant Defenses in Neurons by Repressing p53 Pro-Oxidant Activity

(2009) W. Chatoo et al.   JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

microRNAs at the synapse

(2009) Gerhard Schratt   NATURE REVIEWS NEUROSCIENCE

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease

(2009) Dénes Zádori et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Huntingtin Regulates RE1-silencing Transcription Factor/Neuron-restrictive Silencer Factor (REST/NRSF) Nuclear Trafficking Indirectly through a Complex with REST/NRSF-interacting LIM Domain Protein (RILP) and Dynactin p150Glued

(2008) Masahito Shimojo   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE

Control of chromosome stability by the β-TrCP–REST–Mad2 axis

(2008) Daniele Guardavaccaro et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

(2008) T. Miyawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies

(2008) J. N. Savas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury

(2007) Ferah Yildirim et al.   EXPERIMENTAL NEUROLOGY

Expression of Bmi-1 in Epidermis Enhances Cell Survival by Altering Cell Cycle Regulatory Protein Expression and Inhibiting Apoptosis

(2007) Kathy Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY