Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

(2017) Yitshak I. Francis et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

(2010) P Gaub et al.   CELL DEATH AND DIFFERENTIATION

ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain

(2010) Kristin D. Kernohan et al.   DEVELOPMENTAL CELL

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

Epigenetic mechanisms in the dentate gyrus act as a molecular switch in hippocampus-associated memory formation

(2010) Johannes M.H.M. Reul et al.   Epigenetics

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Histone Methylation Regulates Memory Formation

(2010) S. Gupta et al.   JOURNAL OF NEUROSCIENCE

Cortical DNA methylation maintains remote memory

(2010) Courtney A Miller et al.   NATURE NEUROSCIENCE

DNA methylation and memory formation

(2010) Jeremy J Day et al.   NATURE NEUROSCIENCE

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

(2010) Heh-In Im et al.   NATURE NEUROSCIENCE

MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants

(2010) Jie V Deng et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation

(2010) Z. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

(2010) I. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Mouse Brain

(2010) C. Gregg et al.   SCIENCE

Sex-Specific Parent-of-Origin Allelic Expression in the Mouse Brain

(2010) C. Gregg et al.   SCIENCE

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Active DNA Demethylation Mediated by DNA Glycosylases

(2009) Jian-Kang Zhu   Annual Review of Genetics

SUMO association with repressor complexes, emerging routes for transcriptional control

(2009) Mario Garcia-Dominguez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The early life environment and the epigenome

(2009) Moshe Szyf   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

(2009) Tania L. Roth et al.   BIOLOGICAL PSYCHIATRY

Modulation of Chromatin Modification Facilitates Extinction of Cocaine-Induced Conditioned Place Preference

(2009) Melissa Malvaez et al.   BIOLOGICAL PSYCHIATRY

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Neuroscience of alcoholism: molecular and cellular mechanisms

(2009) Sachin Moonat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Coffin–Lowry syndrome

(2009) Patricia Marques Pereira et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging

(2009) Sjef Copray et al.   GLIA

DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation

(2009) Leah K. Hutnick et al.   HUMAN MOLECULAR GENETICS

Neuronal Differentiation Is Regulated by Leucine-rich Acidic Nuclear Protein (LANP), a Member of the Inhibitor of Histone Acetyltransferase Complex

(2009) Rupinder K. Kular et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

(2009) Zoya Marinova et al.   JOURNAL OF NEUROCHEMISTRY

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

(2009) Hyeon Ju Kim et al.   JOURNAL OF NEUROCHEMISTRY

The pathogenesis of Friedreich ataxia and the structure and function of frataxin

(2009) Massimo Pandolfo et al.   JOURNAL OF NEUROLOGY

Protein Phosphatase 1 Regulates the Histone Code for Long-Term Memory

(2009) K. Koshibu et al.   JOURNAL OF NEUROSCIENCE

Histone Deacetylases 1 and 2 Form a Developmental Switch That Controls Excitatory Synapse Maturation and Function

(2009) M. W. Akhtar et al.   JOURNAL OF NEUROSCIENCE

The Epigenetics of Sex Differences in the Brain

(2009) M. M. McCarthy et al.   JOURNAL OF NEUROSCIENCE

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome

(2009) M. Adachi et al.   JOURNAL OF NEUROSCIENCE

Comprehensive Mapping of Post-Translational Modifications on Synaptic, Nuclear, and Histone Proteins in the Adult Mouse Brain

(2009) Ry Y. Tweedie-Cullen et al.   JOURNAL OF PROTEOME RESEARCH

Histone acetylation is recruited in consolidation as a molecular feature of stronger memories

(2009) N. Federman et al.   LEARNING & MEMORY

Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region

(2009) W. M. U. Daniels et al.   METABOLIC BRAIN DISEASE

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

(2009) Daniel A. Lim et al.   NATURE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

A single standard for memory: the case for reconsolidation

(2009) Karim Nader et al.   NATURE REVIEWS NEUROSCIENCE

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations

(2009) Jennifer L. Larimore et al.   NEUROBIOLOGY OF DISEASE

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

(2009) William Renthal et al.   NEURON

Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex

(2009) Anne Schaefer et al.   NEURON

Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety

(2009) Brigitta B. Gundersen et al.   NEUROPHARMACOLOGY

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Chronic Cocaine-Induced H3 Acetylation and Transcriptional Activation of CaMKIIα in the Nucleus Accumbens Is Critical for Motivation for Drug Reinforcement

(2009) Lei Wang et al.   NEUROPSYCHOPHARMACOLOGY

Selective Boosting of Transcriptional and Behavioral Responses to Drugs of Abuse by Histone Deacetylase Inhibition

(2009) Carles Sanchis-Segura et al.   NEUROPSYCHOPHARMACOLOGY

Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury

(2009) P.K. Dash et al.   NEUROSCIENCE

HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells

(2009) Yong Wang et al.   NEUROSCIENCE LETTERS

Chronic Dietary Administration of Valproic Acid Protects Neurons of the Rat Nucleus Basalis Magnocellularis from Ibotenic Acid Neurotoxicity

(2009) Simona Eleuteri et al.   NEUROTOXICITY RESEARCH

Exercise Improves Cognitive Responses to Psychological Stress through Enhancement of Epigenetic Mechanisms and Gene Expression in the Dentate Gyrus

(2009) Andrew Collins et al.   PLoS One

HDAC6 is a target for protection and regeneration following injury in the nervous system

(2009) M. A. Rivieccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of long-term memory for object recognition via HDAC inhibition

(2009) D. P. Stefanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed

(2009) Simone R. Alt et al.   PSYCHONEUROENDOCRINOLOGY

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

(2009) S. H. Fatemi et al.   SCHIZOPHRENIA BULLETIN

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Epigenetic mechanisms in glioblastoma multiforme

(2009) Raman P. Nagarajan et al.   SEMINARS IN CANCER BIOLOGY

Epigenetic codes in cognition and behaviour

(2008) Johannes Gräff et al.   BEHAVIOURAL BRAIN RESEARCH

NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression

(2008) Yulong L. Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes

(2008) Michael O. Poulter et al.   BIOLOGICAL PSYCHIATRY

The Cognitive Neuroscience of Working Memory: Relevance to CNTRICS and Schizophrenia

(2008) Deanna M. Barch et al.   BIOLOGICAL PSYCHIATRY

Experience-Dependent Epigenetic Modifications in the Central Nervous System

(2008) J. David Sweatt   BIOLOGICAL PSYCHIATRY

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

(2008) Agda KB Lucio-Eterovic et al.   BMC CANCER

RASSF1A,BLU, NORE1A,PTENandMGMTExpression and Promoter Methylation in Gliomas and Glioma Cell Lines and Evidence of Deregulated Expression ofde novo DNMTs

(2008) Aiala Lorente et al.   BRAIN PATHOLOGY

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

HDAC4 inhibits cell-cycle progression and protects neurons from cell death

(2008) Nazanin Majdzadeh et al.   Developmental Neurobiology

Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations

(2008) Elisabetta Tabolacci et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Rett Syndrome: From the Gene to the Disease

(2008) Tanja Matijevic et al.   EUROPEAN NEUROLOGY

GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability

(2008) Erminio Costa et al.   Expert Review of Neurotherapeutics

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

(2008) Anne Granger et al.   FASEB JOURNAL

Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor ( BDNF) gene and histone acetylation at its promoters in the rat hippocampus

(2008) Manabu Fuchikami et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Epigenetic Regulation of the Stem Cell Mitogen Fgf-2 by Mbd1 in Adult Neural Stem/Progenitor Cells

(2008) Xuekun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic programming of μ-opioid receptor gene in mouse brain is regulated by MeCP2 and brg1 chromatin remodelling factor

(2008) Cheol Kyu Hwang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat

(2008) Maria Pascual et al.   JOURNAL OF NEUROCHEMISTRY

Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors

(2008) S. M. Fernandez et al.   JOURNAL OF NEUROSCIENCE

Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition

(2008) Y. Leng et al.   JOURNAL OF NEUROSCIENCE

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

 FosB Mediates Epigenetic Desensitization of the c-fos Gene After Chronic Amphetamine Exposure

(2008) W. Renthal et al.   JOURNAL OF NEUROSCIENCE

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation

(2008) E. D. Nelson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

(2008) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

(2008) B. R. Mueller et al.   JOURNAL OF NEUROSCIENCE

Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism

(2008) S. C. Pandey et al.   JOURNAL OF NEUROSCIENCE

Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction

(2008) M. Lutter et al.   JOURNAL OF NEUROSCIENCE

Epigenetic modifications ofSOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation

(2008) Marianna Sikorska et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

(2008) T. W. Bredy et al.   LEARNING & MEMORY

Histone Ubiquitination: Triggering Gene Activity

(2008) Vikki M. Weake et al.   MOLECULAR CELL

The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes

(2008) M. Kundakovic et al.   MOLECULAR PHARMACOLOGY

Cyclical DNA methylation of a transcriptionally active promoter

(2008) Raphaël Métivier et al.   NATURE

Transient cyclical methylation of promoter DNA

(2008) Sara Kangaspeska et al.   NATURE

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

(2008) Alexi Nott et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress

(2008) Johan Jakobsson et al.   NEURON

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Physical and mental health outcomes of prenatal maternal stress in human and animal studies: a review of recent evidence

(2008) Hind Beydoun et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Epigenetic mechanisms regulating fate specification of neural stem cells

(2008) M. Namihira et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model

(2008) Myriam Rai et al.   PLoS One

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment

(2008) Thomas Burgold et al.   PLoS One

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One

Astrocyte-Specific Genes Are Generally Demethylated in Neural Precursor Cells Prior to Astrocytic Differentiation

(2008) Izuho Hatada et al.   PLoS One

Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome

(2008) Rocio G. Urdinguio et al.   PLoS One

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

(2008) E. A. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Epigenetic programming of the stress response in male and female rats by prenatal restraint stress

(2007) Muriel Darnaudéry et al.   BRAIN RESEARCH REVIEWS

DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity

(2007) Courtney A. Miller et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Epigenetic regulation of kappa opioid receptor gene in neuronal differentiation

(2007) S.W. Park et al.   NEUROSCIENCE

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection

(2007) Rajiv P. Sharma et al.   SCHIZOPHRENIA RESEARCH

Epigenetic memory loss in aging oligodendrocytes in the corpus callosum

(2006) Siming Shen et al.   NEUROBIOLOGY OF AGING

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

(2003) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY