Pitfalls of predicting complex traits from SNPs

Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

(2013) Nilanjan Chatterjee et al.   NATURE GENETICS

The heritability of human disease: estimation, uses and abuses

(2013) Albert Tenesa et al.   NATURE REVIEWS GENETICS

Polygenic Modeling with Bayesian Sparse Linear Mixed Models

(2013) Xiang Zhou et al.   PLoS Genetics

Alzheimer Disease Susceptibility Loci: Evidence for a Protein Network under Natural Selection

(2012) Towfique Raj et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimating Kinship in Admixed Populations

(2012) Timothy Thornton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

Estimating the Genetic Variance of Major Depressive Disorder Due to All Single Nucleotide Polymorphisms

(2012) Gitta H. Lubke et al.   BIOLOGICAL PSYCHIATRY

SparSNP: Fast and memory-efficient analysis of all SNPs for phenotype prediction

(2012) Gad Abraham et al.   BMC BIOINFORMATICS

Partitioning additive genetic variance into genomic and remaining polygenic components for complex traits in dairy cattle

(2012) Just Jensen et al.   BMC GENETICS

Genomic Prediction in Animals and Plants: Simulation of Data, Validation, Reporting, and Benchmarking

(2012) H. D. Daetwyler et al.   GENETICS

Comparing linkage and association analyses in sheep points to a better way of doing GWAS

(2012) KATHRYN E. KEMPER et al.   Genetics Research

Comparison of heritabilities of dairy traits in Australian Holstein-Friesian cattle from genomic and pedigree data and implications for genomic evaluations

(2012) M. Haile-Mariam et al.   JOURNAL OF ANIMAL BREEDING AND GENETICS

Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panels

(2012) M. Erbe et al.   JOURNAL OF DAIRY SCIENCE

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

(2012) Michael C Turchin et al.   NATURE GENETICS

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Genomic and metabolic prediction of complex heterotic traits in hybrid maize

(2012) Christian Riedelsheimer et al.   NATURE GENETICS

Comparison of Statistical Tests for Association between Rare Variants and Binary Traits

(2012) Silviu-Alin Bacanu et al.   PLoS One

Genome-enabled prediction of genetic values using radial basis function neural networks

(2012) J. M. González-Camacho et al.   THEORETICAL AND APPLIED GENETICS

Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster

(2012) Ulrike Ober et al.   PLoS Genetics

Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening

(2011) Hon-Cheong So et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bayesian variable selection regression for genome-wide association studies and other large-scale problems

(2011) Yongtao Guan et al.   Annals of Applied Statistics

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities

(2011) Frauke Becker et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A review of a multifactorial probability-based model for classification of BRCA1 and BRCA2 variants of uncertain significance (VUS)

(2011) Noralane M. Lindor et al.   HUMAN MUTATION

Predicting mutation outcome from early stochastic variation in genetic interaction partners

(2011) Alejandro Burga et al.   NATURE

Genome partitioning of genetic variation for complex traits using common SNPs

(2011) Jian Yang et al.   NATURE GENETICS

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

Beyond Missing Heritability: Prediction of Complex Traits

(2011) Robert Makowsky et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prediction of Genetic Values of Quantitative Traits in Plant Breeding Using Pedigree and Molecular Markers

(2010) J. Crossa et al.   GENETICS

Genetic risk sum score comprised of common polygenic variation is associated with body mass index

(2010) Roseann E. Peterson et al.   HUMAN GENETICS

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes

(2010) Lu Qi et al.   HUMAN MOLECULAR GENETICS

Association Between a Literature-Based Genetic Risk Score and Cardiovascular Events in Women

(2010) Nina P. Paynter   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

A de novo paradigm for mental retardation

(2010) Lisenka E L M Vissers et al.   NATURE GENETICS

Predicting genetic predisposition in humans: the promise of whole-genome markers

(2010) Gustavo de los Campos et al.   NATURE REVIEWS GENETICS

Performance of Common Genetic Variants in Breast-Cancer Risk Models

(2010) Sholom Wacholder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estimating Effects and Making Predictions from Genome-Wide Marker Data

(2010) Michael E. Goddard et al.   STATISTICAL SCIENCE

A Commentary on ‘Common SNPs Explain a Large Proportion of the Heritability for Human Height’ by Yang et al. (2010)

(2010) Peter M. Visscher et al.   Twin Research and Human Genetics

The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling

(2010) Naomi R. Wray et al.   PLoS Genetics

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

(2009) Bruce M. Psaty et al.   Circulation-Cardiovascular Genetics

Predicting Quantitative Traits With Regression Models for Dense Molecular Markers and Pedigree

(2009) G. de los Campos et al.   GENETICS

Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk

(2009) David M. Evans et al.   HUMAN MOLECULAR GENETICS

Invited review: Genomic selection in dairy cattle: Progress and challenges

(2009) B.J. Hayes et al.   JOURNAL OF DAIRY SCIENCE

Maintaining evolvability

(2009) James F. Crow   JOURNAL OF GENETICS

Bayesian statistical methods for genetic association studies

(2009) Matthew Stephens et al.   NATURE REVIEWS GENETICS

Genetic Risk Prediction — Are We There Yet?

(2009) Peter Kraft et al.   NEW ENGLAND JOURNAL OF MEDICINE

From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes

(2009) Zhi Wei et al.   PLoS Genetics

Genomic selection: prediction of accuracy and maximisation of long term response

(2008) Mike Goddard   GENETICA

Natural selection has driven population differentiation in modern humans

(2008) Luis B Barreiro et al.   NATURE GENETICS

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

(2008) Paul D.P. Pharoah et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discerning the Ancestry of European Americans in Genetic Association Studies

(2008) Alkes L. Price et al.   PLoS Genetics

Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach

(2008) Hans D. Daetwyler et al.   PLoS One