Review
Cell Biology
Devesh C. Pant, Taras Y. Nazarko
Summary: Selective autophagy is the specific elimination of certain intracellular substrates through autophagic pathways. Zebrafish has been recognized as an excellent model for studying these processes, shedding light on the understanding of selective autophagy mechanisms.
Review
Medicine, General & Internal
Yizhi Zhang, Yu Chen
Summary: NAFLD is a disorder caused by lipid metabolism, where autophagy plays a crucial role in maintaining intracellular homeostasis, and the activation of hepatocyte autophagy may serve as a treatment for NAFLD.
CHINESE MEDICAL JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Abdul Alim Al-Bari, Yuko Ito, Paul G. Thomes, Manoj B. Menon, Marina Garcia-Macia, Raouf Fadel, Alfreda Stadlin, Nicholas Peake, MoezAlIslam Ezzat Faris, Nabil Eid, Daniel J. Klionsky
Summary: Autophagy is a conserved metabolic process that regulates cellular homeostasis by degrading dysfunctional constituents and invading pathogens. It selectively recycles specific organelles and eliminates liver diseases-related pathogens. Autophagy plays a crucial role in the pathogenesis and treatment of liver diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Wenwen Han, Haiyu Li, Hanqi Jiang, Hang Xu, Yifeng Lin, Jiahuan Chen, Chenchen Bi, Zheng Liu
Summary: Alcohol-related liver disease (ALD) is a chronic liver damage caused by long-term heavy drinking with complex pathogenesis. Autophagy plays a critical role in the occurrence and development of ALD. Some studies have shown that traditional Chinese medicine extracts improve ALD by inducing autophagy and improving oxidative stress and lipid droplet clearance.
Review
Biochemistry & Molecular Biology
Hui Qian, Xiaojuan Chao, Jessica Williams, Sam Fulte, Tiangang Li, Ling Yang, Wen-Xing Ding
Summary: The liver is a crucial metabolic organ, where autophagy plays a significant role in maintaining cellular and metabolic homeostasis. Autophagy in the liver fluctuates with hormonal cues, nutrient availability, and circadian activities. Dysfunctional autophagy may lead to various liver diseases.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Zoology
Sara Falvo, Debora Latino, Alessandra Santillo, Gabriella Chieffi Baccari, Rosalba Senese, Francesca Nuzzolillo, Maria Maddalena Di Fiore
Summary: This study investigated the effects of a high-fat diet on the different regions (caput, corpus, and cauda) of the epididymis in rats. The results showed that the high-fat diet increased oxidative stress and affected the normal function of the epididymis.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Angela Trovato Salinaro, Emanuela Raffone, Tiziana Genovese, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paola
Summary: The study aimed to assess the effects of autophagy and mitophagy induction in a rat model of endometriosis, finding that rapamycin reduced lesion volume, area, and diameter by activating these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Wen Li, Pengcheng He, Yuge Huang, Yi-Fang Li, Jiahong Lu, Min Li, Hiroshi Kurihara, Zhuo Luo, Tian Meng, Mashun Onishi, Changle Ma, Lei Jiang, Yongquan Hu, Qing Gong, Dongxing Zhu, Yiming Xu, Rong Liu, Lei Liu, Cong Yi, Yushan Zhu, Ningfang Ma, Koji Okamoto, Zhiping Xie, Jinbao Liu, Rong-Rong He, Du Feng
Summary: Autophagy is a physiological process that degrades over-abundant or damaged organelles via the lysosomal system, induced by stress and occurring in both non-selective and selective manners. Selective autophagy plays a crucial role in maintaining cellular homeostasis and its dysfunction is implicated in various diseases.
Article
Biochemistry & Molecular Biology
Fang Yuan, Yingying Xu, Kai You, Jiaye Zhang, Fan Yang, Yin-xiong Li
Summary: The study showed that calcitriol can alleviate ethanol-induced hepatocyte damage by enhancing autophagy, providing a convenient preventive and hepatoprotective means for people who occasionally engage in social drinking. Autophagy is significantly enhanced by calcitriol, and the effect is mediated through the AMPK/mTOR signaling pathway and dependent on the Vitamin D receptor (VDR).
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Nutrition & Dietetics
Genis Camprecios, Maria Ruart, Aina Anton, Nuria Suarez-Herrera, Carla Montironi, Celia Martinez, Natalia Jimenez, Erica Lafoz, Hector Garcia-Caldero, Marina Vilaseca, Marta Magaz, Mar Coll, Isabel Graupera, Scott L. Friedman, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Research on the use of SPD in two models of liver disease shows that SPD can improve the function of liver endothelial cells, reduce liver oxidative stress, and enhance mitochondrial health. These findings suggest that dietary supplementation with SPD in the early stages of the disease may protect liver endothelial cells, serving as an attractive approach to modify the course of chronic liver disease and halt fibrosis progression.
Review
Biochemistry & Molecular Biology
Xinjie Guan, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Chengfu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, King-Ho Cheung, Jiahong Lu, Jieqiong Tan, Min Li
Summary: Selective autophagy plays an important role in the pathogenesis of Alzheimer's disease, and regulating selective autophagy can be an effective strategy for controlling this pathological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Hongkun Lin, Xiaoping Guo, Jingjing Liu, Peiyi Liu, Guibin Mei, Hongxia Li, Dan Li, Huimin Chen, Li Chen, Ying Zhao, Chunjie Jiang, Yaqin Yu, Wen Liu, Ping Yao
Summary: Chronic alcohol consumption leads to lipophagy disorder, which contributes to the development of liver steatosis. This study found that the hepatoprotective phytochemical quercetin can attenuate hepatic steatosis by normalizing the disruption of Rab7 turnover and lipophagy caused by ethanol. These findings highlight a novel mechanism and the promising therapeutic potential of quercetin-like compounds against alcohol-induced liver damage.
Article
Biochemistry & Molecular Biology
Peng Cao, Yi Wang, Cong Zhang, Mitchell A. Sullivan, Wen Chen, Xiang Jing, Huifan Yu, Fei Li, Qu Wang, Zhongshi Zhou, Qi Wang, Wen Tian, Zhenpeng Qiu, Lianxiang Luo
Summary: This study aims to further elucidate the potential mechanism of action of quercetin in alleviating nonalcoholic fatty liver disease (NAFLD). It was found that quercetin prevents NAFLD through AMPK-mediated mitophagy, suggesting that promoting mitophagy via an upregulation of AMPK may be a promising therapeutic strategy against NAFLD.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Maomao Pu, Wenhui Zheng, Hongtao Zhang, Wei Wan, Chao Peng, Xuebo Chen, Xinchang Liu, Zizhen Xu, Tianhua Zhou, Qiming Sun, Dante Neculai, Wei Liu
Summary: This study found that lipophagy, the process of autophagosomes engulfing and degrading lipid droplets, is crucial for lipid and energy homeostasis. The lipid transfer protein ORP8 was found to be located on lipid droplets and mediates their encapsulation by autophagosomal membranes through direct interaction with LC3/GABARAPs. Phosphorylation of ORP8 by AMPK enhances its affinity for LC3/GABARAPs. Deletion or disruption of the ORP8-LC3/GABARAP interaction leads to lipid droplet accumulation and increased intracellular triglyceride.
Article
Cell Biology
Fengfeng Ping, Chao Zhang, Xue Wang, Yan Wang, Danli Zhou, Jing Hu, Yanhua Chen, Jingjing Ling, Jia Zhou
Summary: The study showed that inhibition of Cx32 could alleviate injury and activate autophagy during cerebral ischemia-reperfusion, while also promoting mitophagy. Nur77 expression was regulated by Cx32, affecting the neuronal autophagy process.
Meeting Abstract
Immunology
Akio Horibe, Nabil Eid, Yuko Ito, Yoshihisa Tanaka, Yoshinori Otsuki, Yoichi Kondo
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Pharmacology & Pharmacy
Nabil Eid, Yuko Ito, Yoshinori Otsuki
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Akio Horibe, Nabil Eid, Yuko Ito, Hitomi Hamaoka, Yoshihisa Tanaka, Yoichi Kondo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Anatomy & Morphology
N. Eid, Y. Ito, S. Futaki, Y. Kondo
FOLIA MORPHOLOGICA
(2018)
Editorial Material
Cell Biology
Partha Mukhopadhyay, Nabil Eid, Mohamed A. Abdelmegeed, Aditya Sen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Letter
Environmental Sciences
Nabil Eid, Yoichi Kondo
ENVIRONMENTAL POLLUTION
(2018)
Article
Biochemistry & Molecular Biology
Akio Horibe, Nabil Eid, Yuko Ito, Yoshinori Otsuki, Yoichi Kondo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Nabil Eid, Yuko Ito, Akio Horibe, Yoshinori Otsuki, Yoichi Kondo
Editorial Material
Pharmacology & Pharmacy
Nabil Eid, Manoj B. Menon, Paul Thomes, Tao Zeng, Nuno Raimundo, Jose C. Fernandez-Checa, Lin Wang, Yuko Ito, Yoshinori Otsuki, Ernest Adeghate
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yuko Ito, Kohei Taniguchi, Yuki Kuranaga, Nabil Eid, Yosuke Inomata, Sang-Woong Lee, Kazuhisa Uchiyama
Summary: Edible plant cells produce EVs containing various miRNAs, which are released into central vacuoles, and these exogenous plant EVs can be taken up by mammalian enterocytes in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Md Abdul Alim Al-Bari, Yuko Ito, Samrein Ahmed, Nada Radwan, Hend S. Ahmed, Nabil Eid
Summary: Autophagy is a highly conserved eukaryotic intracellular process that can be regulated to affect various disease processes. Natural products have potential advantages in anticancer drug discovery, making them potential novel anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ryoko Okuno, Yuko Ito, Nabil Eid, Yoshinori Otsuki, Yoichi Kondo, Koichi Ueda
HISTOLOGY AND HISTOPATHOLOGY
(2018)
Meeting Abstract
Substance Abuse
N. Eid, Y. Ito, A. Horibe, H. Hamaoka, Y. Tanaka, Y. Otsuki, Y. Kondo
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Andrology
N. Eid, Y. Kondo
Article
Cell Biology
Tsubasa Betsuyaku, Nabil Eid, Yuko Ito, Yoshihisa Tanaka, Yoshinori Otsuki, Yoichi Kondo
HISTOLOGY AND HISTOPATHOLOGY
(2017)