Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
出版年份 2017 全文链接
标题
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
作者
关键词
-
出版物
NATURE MEDICINE
Volume 23, Issue 8, Pages 917-928
出版商
Springer Nature
发表日期
2017-08-05
DOI
10.1038/nm.4381
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
- (2017) James S McCarthy et al. LANCET INFECTIOUS DISEASES
- The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study
- (2017) Mallika Imwong et al. LANCET INFECTIOUS DISEASES
- Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study
- (2017) Roberto Amato et al. LANCET INFECTIOUS DISEASES
- A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study
- (2017) Benoit Witkowski et al. LANCET INFECTIOUS DISEASES
- In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate
- (2017) Fabian Baumgärtner et al. MALARIA JOURNAL
- A high susceptibility to redox imbalance of the transmissible stages ofPlasmodium falciparumrevealed with a luciferase-based mature gametocyte assay
- (2017) Giulia Siciliano et al. MOLECULAR MICROBIOLOGY
- Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa
- (2017) Feng Lu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
- (2017) Tanya Paquet et al. Science Translational Medicine
- Is the Mitochondrion a Good Malaria Drug Target?
- (2017) Christopher D. Goodman et al. TRENDS IN PARASITOLOGY
- A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine
- (2017) Satish K. Dhingra et al. mBio
- Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro
- (2017) Judith Straimer et al. mBio
- A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
- (2017) Paul M. O’Neill et al. Nature Communications
- A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
- (2017) Ebere Sonoiki et al. Nature Communications
- Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis
- (2017) Wilson Wong et al. Nature Microbiology
- Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis
- (2017) Evaristus Chibunna Mbanefo et al. Scientific Reports
- Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda
- (2016) Fredrick Kateera et al. ACTA TROPICA
- Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains
- (2016) Tuo Yang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes
- (2016) Leonardo Lucantoni et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype
- (2016) A. Siriwardana et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission
- (2016) David M. Plouffe et al. Cell Host & Microbe
- Declining Efficacy of Artemisinin Combination Therapy AgainstP. FalciparumMalaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors
- (2016) Aung Pyae Phyo et al. CLINICAL INFECTIOUS DISEASES
- How to tackle antimalarial resistance?
- (2016) Didier Leroy EMBO Molecular Medicine
- A chemical susceptibility profile of thePlasmodium falciparumtransmission stages by complementary cell-based gametocyte assays
- (2016) Sarah D'Alessandro et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
- (2016) Alimuddin Zumla et al. LANCET INFECTIOUS DISEASES
- Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial
- (2016) Aung Pyae Phyo et al. LANCET INFECTIOUS DISEASES
- Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study
- (2016) Chanaki Amaratunga et al. LANCET INFECTIOUS DISEASES
- Cost effectiveness of intermittent screening followed by treatment versus intermittent preventive treatment during pregnancy in West Africa: analysis and modelling of results from a non-inferiority trial
- (2016) Silke Fernandes et al. MALARIA JOURNAL
- A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study
- (2016) James S. McCarthy et al. MALARIA JOURNAL
- Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India
- (2016) Neelima Mishra et al. MALARIA JOURNAL
- Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites
- (2016) Timothy J.C. Anderson et al. MOLECULAR BIOLOGY AND EVOLUTION
- Combinatorial Genetic Modeling ofpfcrt-Mediated Drug Resistance Evolution inPlasmodium falciparum
- (2016) Stanislaw J. Gabryszewski et al. MOLECULAR BIOLOGY AND EVOLUTION
- Structure- and function-based design of Plasmodium-selective proteasome inhibitors
- (2016) Hao Li et al. NATURE
- Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
- (2016) Nobutaka Kato et al. NATURE
- Dihydroartemisinin–Piperaquine for the Prevention of Malaria in Pregnancy
- (2016) Abel Kakuru et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms
- (2016) Didier Ménard et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria
- (2016) Nicholas J. White et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunity to malaria in an era of declining malaria transmission
- (2016) FREYA J. I. FOWKES et al. PARASITOLOGY
- Seasonal Malaria Chemoprevention with Sulphadoxine-Pyrimethamine and Amodiaquine Selects Pfdhfr-dhps Quintuple Mutant Genotype in Mali
- (2016) Hamma Maiga et al. PLoS One
- Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia
- (2016) Kristina R. Kesely et al. PLoS One
- Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes
- (2016) C. D. Goodman et al. SCIENCE
- Targeting Protein Translation in Organelles of the Apicomplexa
- (2016) Christopher D. Goodman et al. TRENDS IN PARASITOLOGY
- Artemisinin Action and Resistance in Plasmodium falciparum
- (2016) Leann Tilley et al. TRENDS IN PARASITOLOGY
- Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance
- (2016) Gregory LaMonte et al. mBio
- A broad analysis of resistance development in the malaria parasite
- (2016) Victoria C. Corey et al. Nature Communications
- Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
- (2016) M. Isabel Veiga et al. Nature Communications
- Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
- (2016) Marek Cyrklaff et al. Nature Communications
- Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria
- (2016) Sesh A. Sundararaman et al. Nature Communications
- Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
- (2016) Stanislaw J. Gabryszewski et al. PLoS Pathogens
- Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter
- (2016) Sashika N. Richards et al. PLoS Pathogens
- Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes
- (2016) Pamela A. Magistrado et al. ACS Infectious Diseases
- UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes
- (2016) Michelle Yi-Xiu Lim et al. Nature Microbiology
- Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites
- (2016) Andrew H. Lee et al. PLoS One
- Antimalarial drug resistance in Africa: key lessons for the future
- (2015) Shannon Takala-Harrison et al. Annals of the New York Academy of Sciences
- Ion Regulation in the Malaria Parasite
- (2015) Kiaran Kirk Annual Review of Microbiology
- Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border
- (2015) David L. Saunders et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Molecular Characterization of the CytochromebGene andIn VitroAtovaquone Susceptibility of Plasmodium falciparum Isolates from Kenya
- (2015) Luicer A. Ingasia et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)
- (2015) Paul S. Callaghan et al. BIOCHEMISTRY
- Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations
- (2015) Valentine Duru et al. BMC Medicine
- Haemoglobin degradation underpins the sensitivity of early ring stagePlasmodium falciparumto artemisinins
- (2015) Stanley C. Xie et al. JOURNAL OF CELL SCIENCE
- Ferroquine: welcome to the next generation of antimalarials
- (2015) Timothy NC Wells et al. LANCET INFECTIOUS DISEASES
- Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study
- (2015) Jana Held et al. LANCET INFECTIOUS DISEASES
- Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
- (2015) Kyaw M Tun et al. LANCET INFECTIOUS DISEASES
- Population Structure Shapes Copy Number Variation in Malaria Parasites
- (2015) Ian H. Cheeseman et al. MOLECULAR BIOLOGY AND EVOLUTION
- Balancing drug resistance and growth rates via compensatory mutations in thePlasmodium falciparumchloroquine resistance transporter
- (2015) Ines Petersen et al. MOLECULAR MICROBIOLOGY
- A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
- (2015) Alassane Mbengue et al. NATURE
- A novel multiple-stage antimalarial agent that inhibits protein synthesis
- (2015) Beatriz Baragaña et al. NATURE
- Genetic architecture of artemisinin-resistant Plasmodium falciparum
- (2015) Olivo Miotto et al. NATURE GENETICS
- Brain Swelling and Death in Children with Cerebral Malaria
- (2015) Karl B. Seydel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Direct evidence for the atovaquone action on the Plasmodium cytochrome bc 1 complex
- (2015) Josephine E. Siregar et al. PARASITOLOGY INTERNATIONAL
- Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation inpfcrt
- (2015) Stéphane Pelleau et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
- (2015) Margaret A. Phillips et al. Science Translational Medicine
- Active migration and passive transport of malaria parasites
- (2015) Ross G. Douglas et al. TRENDS IN PARASITOLOGY
- Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa
- (2015) Brandyce St. Laurent et al. Nature Communications
- Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities
- (2015) Serena Pulcini et al. Scientific Reports
- Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
- (2015) Con Dogovski et al. PLOS BIOLOGY
- Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach
- (2015) Lisa J. White et al. PLOS MEDICINE
- Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials
- (2014) Erika L. Flannery et al. ACS Chemical Biology
- Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
- (2014) Meera Venkatesan et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- The Peculiarities and Paradoxes of Plasmodium Heme Metabolism
- (2014) Paul A. Sigala et al. Annual Review of Microbiology
- Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Malaria in Children in Zaire and Uíge Provinces, Angola
- (2014) Mateusz M. Plucinski et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Emergence of Resistance to Atovaquone-Proguanil in Malaria Parasites: Insights from Computational Modeling and Clinical Case Reports
- (2014) Gilles Cottrell et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission
- (2014) Kelli L. Kuhen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites
- (2014) C. M. Smith et al. BLOOD
- Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in Ugandan Children
- (2014) Melissa D. Conrad et al. JOURNAL OF INFECTIOUS DISEASES
- Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia
- (2014) Shannon Takala-Harrison et al. JOURNAL OF INFECTIOUS DISEASES
- Artemisinin resistance – modelling the potential human and economic costs
- (2014) Yoel Lubell et al. MALARIA JOURNAL
- The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment
- (2014) Richard J Maude et al. MALARIA JOURNAL
- Primaquine: the risks and the benefits
- (2014) Elizabeth A Ashley et al. MALARIA JOURNAL
- Pharmacological considerations in the design of anti-malarial drug combination therapies – is matching half-lives enough?
- (2014) Ian M Hastings et al. MALARIA JOURNAL
- Origin of Robustness in Generating Drug-Resistant Malaria Parasites
- (2014) Krittikorn Kümpornsin et al. MOLECULAR BIOLOGY AND EVOLUTION
- Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
- (2014) Mehdi Ghorbal et al. NATURE BIOTECHNOLOGY
- Reappraisal of known malaria resistance loci in a large multicenter study
- (2014) Kirk A Rockett et al. NATURE GENETICS
- The Origins of Antimalarial-Drug Resistance
- (2014) Randall M. Packard NEW ENGLAND JOURNAL OF MEDICINE
- Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
- (2014) Elizabeth A. Ashley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Spiroindolone KAE609 for Falciparum and Vivax Malaria
- (2014) Nicholas J. White et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dihydroartemisinin–Piperaquine Failure in Cambodia
- (2014) David L. Saunders et al. NEW ENGLAND JOURNAL OF MEDICINE
- Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance
- (2014) A. K. Lukens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance ofPlasmodium
- (2014) María Belén Jiménez-Díaz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
- (2014) J. Straimer et al. SCIENCE
- Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
- (2014) S. Mok et al. SCIENCE
- Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
- (2014) Dominic Birth et al. Nature Communications
- Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
- (2014) Akhil B. Vaidya et al. Nature Communications
- Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
- (2014) Antoine Claessens et al. PLoS Genetics
- A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum
- (2014) Cecilia P. Sanchez et al. PLoS Genetics
- Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism
- (2014) Ian A. Lewis et al. PLoS Genetics
- Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization
- (2013) Nicholas J. White ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
- (2013) Natalie J. Spillman et al. Cell Host & Microbe
- Antimalarial pharmacology and therapeutics of atovaquone
- (2013) G. L. Nixon et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential
- (2013) Thomas Antoine et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Malaria
- (2013) Nicholas J White et al. LANCET
- Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
- (2013) Benoit Witkowski et al. LANCET INFECTIOUS DISEASES
- In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene
- (2013) Aurélie Pascual et al. MALARIA JOURNAL
- CRIMALDDI: platform technologies and novel anti-malarial drug targets
- (2013) Henri Vial et al. MALARIA JOURNAL
- The interplay between drug resistance and fitness in malaria parasites
- (2013) Philip J. Rosenthal MOLECULAR MICROBIOLOGY
- Targeting Plasmodium PI(4)K to eliminate malaria
- (2013) Case W. McNamara et al. NATURE
- A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
- (2013) Frédéric Ariey et al. NATURE
- Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
- (2013) Olivo Miotto et al. NATURE GENETICS
- Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
- (2013) N. Klonis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families
- (2013) Selina E. R. Bopp et al. PLoS Genetics
- Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis
- (2013) Steve M. Taylor et al. PLoS Pathogens
- Insights into the Role of Heme in the Mechanism of Action of Antimalarials
- (2012) Jill M. Combrinck et al. ACS Chemical Biology
- Efficacy of Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010
- (2012) R. Leang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector
- (2012) J. C. van Pelt-Koops et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc 1 Catalytic Turnover and Protein Expression
- (2012) Nicholas Fisher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A framework for assessing the risk of resistance for anti-malarials in development
- (2012) Xavier C Ding et al. MALARIA JOURNAL
- Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
- (2012) Y. Yuthavong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites
- (2012) Souvik Bhattacharjee et al. TRENDS IN PARASITOLOGY
- PfCRT and its role in antimalarial drug resistance
- (2012) Andrea Ecker et al. TRENDS IN PARASITOLOGY
- Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites
- (2011) Richard T. Eastman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
- (2011) T. Bousema et al. CLINICAL MICROBIOLOGY REVIEWS
- Drug-resistant malaria: Molecular mechanisms and implications for public health
- (2011) Ines Petersen et al. FEBS LETTERS
- A new world malaria map: Plasmodium falciparum endemicity in 2010
- (2011) Peter W Gething et al. MALARIA JOURNAL
- Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
- (2011) S. H. Adjalley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
- (2011) S. A. Charman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery
- (2011) S. Meister et al. SCIENCE
- Transmission and Cross-Mating of High-Level Resistance Plasmodium falciparum Dihydrofolate Reductase Haplotypes in The Gambia
- (2010) Amani Kheir et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Origin and Dissemination across the Colombian Andes Mountain Range of Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum
- (2010) V. Corredor et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Intrahost modeling of artemisinin resistance in Plasmodium falciparum
- (2010) S. Saralamba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spiroindolones, a Potent Compound Class for the Treatment of Malaria
- (2010) M. Rottmann et al. SCIENCE
- Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum
- (2009) Toshihiro Mita ACTA TROPICA
- ORIGINAL ARTICLE: Probability of emergence of antimalarial resistance in different stages of the parasite life cycle
- (2009) Wirichada Pongtavornpinyo et al. Evolutionary Applications
- In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa
- (2009) Christin Sisowath et al. JOURNAL OF INFECTIOUS DISEASES
- Discovery of dual function acridones as a new antimalarial chemotype
- (2009) Jane X. Kelly et al. NATURE
- Artemisinin Resistance inPlasmodium falciparumMalaria
- (2009) Arjen M. Dondorp et al. NEW ENGLAND JOURNAL OF MEDICINE
- Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine
- (2009) Juliana Martha Sá et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Photoaffinity Labeling of thePlasmodium falciparumChloroquine Resistance Transporter with a Novel Perfluorophenylazido Chloroquine†
- (2008) Jacqueline K. Lekostaj et al. BIOCHEMISTRY
- A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites
- (2008) A. M. Lehane et al. JOURNAL OF CELL SCIENCE
- Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil
- (2008) Colin J Sutherland et al. MALARIA JOURNAL
- Evidence of Artemisinin-Resistant Malaria in Western Cambodia
- (2008) Harald Noedl et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adaptive Copy Number Evolution in Malaria Parasites
- (2008) Shalini Nair et al. PLoS Genetics
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now