Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The evolutionary landscape of antifolate resistance in Plasmodium falciparum

(2011) MARNA S. COSTANZO et al.   JOURNAL OF GENETICS

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria

(2011) Renato T. Skerlj et al.   ACS Medicinal Chemistry Letters

Novel Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

(2010) Michael L. Booker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions

(2009) Tobias Bollenbach et al.   CELL

In vitro selection of Plasmodium falciparum drug-resistant parasite lines

(2009) A. Nzila et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

(2009) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase

(2009) M. J. Edwards et al.   SCIENCE

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

Analysis of Flavin Oxidation and Electron-Transfer Inhibition inPlasmodium falciparumDihydroorotate Dehydrogenase†

(2008) Nicholas A. Malmquist et al.   BIOCHEMISTRY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH