A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum

Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects

(2013) Martin Scheffner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid Proteins

(2013) Swati Agrawal et al.   PLoS Pathogens

Biosynthesis, Localization, and Macromolecular Arrangement of thePlasmodium falciparumTranslocon of Exported Proteins (PTEX)

(2012) Hayley E. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Longitudinal in vitro surveillance of Plasmodium falciparum sensitivity to common anti-malarials in Thailand between 1994 and 2010

(2012) Daniel Parker et al.   MALARIA JOURNAL

Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum

(2012) Teera Poyomtip et al.   MALARIA JOURNAL

Ex vivo drug sensitivity profiles of Plasmodium falciparum field isolates from Cambodia and Thailand, 2005 to 2010, determined by a histidine-rich protein-2 assay

(2012) Stuart D Tyner et al.   MALARIA JOURNAL

The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells

(2012) Alyssa Ingmundson et al.   MOLECULAR MICROBIOLOGY

Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway

(2012) Duk-Won D. Chung et al.   PLoS One

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

(2012) D. J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

(2011) Elena Maspero et al.   EMBO REPORTS

In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo

(2011) Sébastien Briolant et al.   MALARIA JOURNAL

Update on genetic markers of quinine resistance in Plasmodium falciparum

(2011) John Okombo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

(2011) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum-Infected Erythrocytes

(2011) M. Cyrklaff et al.   SCIENCE

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites

(2010) Dorothee Beez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Decreased In Vitro Susceptibility of Plasmodium falciparum Isolates to Artesunate, Mefloquine, Chloroquine, and Quinine in Cambodia from 2001 to 2007

(2010) P. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

(2010) J. Okombo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Limited Ability ofPlasmodium falciparum pfcrt,pfmdr1, andpfnhe1Polymorphisms To Predict QuinineIn VitroSensitivity or Clinical Effectiveness in Uganda

(2010) Frederick N. Baliraine et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Sensitivities of Plasmodium falciparum to Different Antimalarial Drugs in Uganda

(2010) S. L. Nsobya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transporters as mediators of drug resistance in Plasmodium falciparum

(2010) Cecilia P. Sanchez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex

(2010) John N. Alumasa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

(2010) Perri Pleeter et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

(2010) Jigar J. Patel et al.   MOLECULAR MICROBIOLOGY

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

(2010) Jianbing Mu et al.   NATURE GENETICS

Sensitivity to artemisinin, mefloquine and quinine of Plasmodium falciparum in northwestern Thailand

(2010) Felix Hüttinger et al.   WIENER KLINISCHE WOCHENSCHRIFT

Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate

(2009) Wanna Chaijaroenkul et al.   ACTA TROPICA

Plasmodium falciparum Na+/H+ Exchanger 1 Transporter Is Involved in Reduced Susceptibility to Quinine

(2009) M. Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells

(2009) Ye Zhang et al.   JOURNAL OF PATHOLOGY

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

(2009) Louis J. Nkrumah et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

Trafficking of the Phosphoprotein PfCRT to the Digestive Vacuolar Membrane inPlasmodium falciparum

(2009) Yvonne Kuhn et al.   TRAFFIC

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

(2009) Neekesh V Dharia et al.   GENOME BIOLOGY

Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray

(2008) Hongying Jiang et al.   BMC GENOMICS

A conditional export system provides new insights into protein export inPlasmodium falciparum-infected erythrocytes

(2008) Theodora Saridaki et al.   CELLULAR MICROBIOLOGY

Dissecting the components of quinine accumulation in Plasmodium falciparum

(2008) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

Deciphering the Ubiquitin-Mediated Pathway in Apicomplexan Parasites: A Potential Strategy to Interfere with Parasite Virulence

(2008) Nadia Ponts et al.   PLoS One