Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

(2017) Mitasha Bharadwaj et al.   Nature Communications

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

(2016) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

(2015) Rishita Changede et al.   DEVELOPMENTAL CELL

The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions

(2015) H. E. Balcioglu et al.   JOURNAL OF CELL SCIENCE

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

Increasing throughput of AFM-based single cell adhesion measurements through multisubstrate surfaces

(2015) Miao Yu et al.   Beilstein Journal of Nanotechnology

Assay for characterizing the recovery of vertebrate cells for adhesion measurements by single-cell force spectroscopy

(2014) Rajib Schubert et al.   FEBS LETTERS

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of talin-dependent integrin signaling and crosstalk

(2013) Mitali Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

A practical guide to quantify cell adhesion using single-cell force spectroscopy

(2013) Jens Friedrichs et al.   METHODS

Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions

(2013) Fang Kong et al.   MOLECULAR CELL

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Quantifying cellular adhesion to extracellular matrix components by single-cell force spectroscopy

(2010) Jens Friedrichs et al.   Nature Protocols

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Force probing surfaces of living cells to molecular resolution

(2009) Daniel J Müller et al.   Nature Chemical Biology

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

A Bond for a Lifetime: Employing Membrane Nanotubes from Living Cells to Determine Receptor-Ligand Kinetics

(2008) Michael Krieg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catch Bonds in Adhesion

(2008) Wendy Thomas   Annual Review of Biomedical Engineering

The role of integrin binding sites in fibronectin matrix assembly in vivo

(2008) Michael Leiss et al.   CURRENT OPINION IN CELL BIOLOGY

Cell adhesion receptors in mechanotransduction

(2008) Martin A Schwartz et al.   CURRENT OPINION IN CELL BIOLOGY

Single-cell force spectroscopy

(2008) J. Helenius et al.   JOURNAL OF CELL SCIENCE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Rapid signal transduction in living cells is a unique feature of mechanotransduction

(2008) S. Na et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA