Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Integrin Molecular Tension within Motile Focal Adhesions

(2015) Xuefeng Wang et al.   BIOPHYSICAL JOURNAL

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired  2 integrin function in mice

(2015) S. Klapproth et al.   BLOOD

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

(2015) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Visualizing the Interior Architecture of Focal Adhesions with High-Resolution Traction Maps

(2015) Masatoshi Morimatsu et al.   NANO LETTERS

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

(2014) S. Stritt et al.   BLOOD

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity

(2014) Yong Yang et al.   PLoS One

Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling

(2014) Yu-Chung Chang et al.   STRUCTURE

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration

(2013) Thomas Iskratsch et al.   DEVELOPMENTAL CELL

CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor

(2013) Babet van der Vaart et al.   DEVELOPMENTAL CELL

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

(2012) Xianqiang Song et al.   CELL RESEARCH

Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type I  in vivo

(2012) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2synthesis

(2011) Kyle R Legate et al.   EMBO JOURNAL

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Multiple oligomerization domains of KANK1-PDGFR  are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK

(2011) S. Medves et al.   HAEMATOLOGICA

Adhesion dynamics at a glance

(2011) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine–vulval attachment in Caenorhabditis elegans

(2011) Shinji Ihara et al.   NATURE CELL BIOLOGY

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

(2010) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

Kank proteins: structure, functions and diseases

(2009) N. Kakinuma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Control of High Affinity Interactions in the Talin C Terminus

(2009) Mirko Himmel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Multi-level molecular clutches in motile cell processes

(2009) Grégory Giannone et al.   TRENDS IN CELL BIOLOGY

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K–Akt signaling

(2008) Naoto Kakinuma et al.   JOURNAL OF CELL BIOLOGY

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE