Talins and kindlins: partners in integrin-mediated adhesion

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I   by HECTD1 regulates focal adhesion dynamics and cell migration

(2013) X. Li et al.   JOURNAL OF CELL SCIENCE

Two modes of integrin activation form a binary molecular switch in adhesion maturation

(2013) Ho-Sup Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

(2013) Weizhi Liu et al.   MOLECULAR CELL

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

(2012) Emmanuel Debrand et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

αVβ3 Integrin Crystal Structures and Their Functional Implications

(2012) Xianchi Dong et al.   BIOCHEMISTRY

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

(2012) Xianqiang Song et al.   CELL RESEARCH

Distinct Roles of Talin and Kindlin in Regulating Integrin α5β1 Function and Trafficking

(2012) Coert Margadant et al.   CURRENT BIOLOGY

Phosphoinositide Signaling Regulates the Exocyst Complex and Polarized Integrin Trafficking in Directionally Migrating Cells

(2012) Narendra Thapa et al.   DEVELOPMENTAL CELL

The MRL proteins: Adapting cell adhesion, migration and growth

(2012) Georgina P. Coló et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain

(2012) Luke A. Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular Localization of Talin Is Regulated by Inter-domain Interactions

(2012) Asoka Banno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biophysical Analysis of Kindlin-3 Reveals an Elongated Conformation and Maps Integrin Binding to the Membrane-distal β-Subunit NPXY Motif

(2012) Luke A. Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin1 Has Unique ExpressionversusTalin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload

(2012) Ana Maria Manso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails

(2012) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Filamin-binding LIM Protein 1 (FBLP-1)/Migfilin in Regulation of Bone Remodeling

(2012) Guozhi Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Mechanism for the Requirement of PAT-4 (Integrin-linked Kinase (ILK)) for the Localization of UNC-112 (Kindlin) to Integrin Adhesion Sites

(2012) Hiroshi Qadota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated αIIbβ3 Integrin Coactivation

(2012) Mohamed Bouaouina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Cell Adhesion and Migration by Kindlin-3 Cleavage by Calpain

(2012) Yongzhong Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin activates integrins by altering the topology of the β transmembrane domain

(2012) Chungho Kim et al.   JOURNAL OF CELL BIOLOGY

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector

(2012) Joseph P. Wynne et al.   JOURNAL OF CELL BIOLOGY

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration

(2012) Shujie Wang et al.   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

(2012) Florian Steinberg et al.   JOURNAL OF CELL BIOLOGY

Arginylation-dependent regulation of a proteolytic product of talin is essential for cell–cell adhesion

(2012) Fangliang Zhang et al.   JOURNAL OF CELL BIOLOGY

Zasp regulates integrin activation

(2012) M. Bouaouina et al.   JOURNAL OF CELL SCIENCE

Functional differences between kindlin-1 and kindlin-2 in keratinocytes

(2012) A. Bandyopadhyay et al.   JOURNAL OF CELL SCIENCE

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Integrin trafficking at a glance

(2012) R. E. Bridgewater et al.   JOURNAL OF CELL SCIENCE

Talin1 and Rap1 Are Critical for Osteoclast Function

(2012) W. Zou et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3

(2012) Bryan N. Kahner et al.   PLoS One

Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins

(2012) Nichol L. G. Miller et al.   PLoS One

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

(2012) Neil Bate et al.   PLoS One

The Primacy of β1 Integrin Activation in the Metastatic Cascade

(2012) Hisashi Kato et al.   PLoS One

Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation

(2012) Yan Liu et al.   Protein & Cell

Cross-Correlated Fluctuation Analysis Reveals Phosphorylation-Regulated Paxillin-FAK Complexes in Nascent Adhesions

(2011) Colin K. Choi et al.   BIOPHYSICAL JOURNAL

Kindlins

(2011) Mohamed Bouaouina et al.   CURRENT BIOLOGY

Kindlin

(2011) Feng Ye et al.   CURRENT OPINION IN HEMATOLOGY

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2synthesis

(2011) Kyle R Legate et al.   EMBO JOURNAL

Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

(2011) Jianmin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C terminus of talin links integrins to cell cycle progression

(2011) Pengbo Wang et al.   JOURNAL OF CELL BIOLOGY

Loss of migfilin expression has no overt consequences on murine development and homeostasis

(2011) D. V. Moik et al.   JOURNAL OF CELL SCIENCE

In vivo functional analysis reveals specific roles for the integrin-binding sites of talin

(2011) S. J. Ellis et al.   JOURNAL OF CELL SCIENCE

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins

(2011) H. Qu et al.   JOURNAL OF CELL SCIENCE

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanism of inside-out integrin regulation

(2011) F. YE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Talin1 Regulates Integrin Turnover To Promote Embryonic Epithelial Morphogenesis

(2011) J. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Basic amino-acid side chains regulate transmembrane integrin signalling

(2011) Chungho Kim et al.   NATURE

Migfilin and Filamin as Regulators of Integrin Activation in Endothelial Cells and Neutrophils

(2011) Mitali Das et al.   PLoS One

Multiscale simulations suggest a mechanism for integrin inside-out activation

(2011) A. C. Kalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity of talin-1 for the  3-integrin cytosolic domain is modulated by its phospholipid bilayer environment

(2011) D. T. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation

(2011) H. Dhanuja Perera et al.   STRUCTURE

The tail of integrin activation

(2011) Nicholas J. Anthis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

A potential role for  -actinin in inside-out  IIb 3 signaling

(2010) S. Tadokoro et al.   BLOOD

Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen

(2010) E. Manevich-Mendelson et al.   BLOOD

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

Endothelial cell talin1 is essential for embryonic angiogenesis

(2010) Susan J. Monkley et al.   DEVELOPMENTAL BIOLOGY

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

(2010) Petra M. Kopp et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site

(2010) Benjamin T. Goult et al.   FEBS LETTERS

Tyrosine Phosphorylation of Integrin β3Regulates Kindlin-2 Binding and Integrin Activation

(2010) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell

(2010) Katarzyna Bialkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

(2010) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

The kindlins at a glance

(2010) E. Karakose et al.   JOURNAL OF CELL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Structural Diversity in Integrin/Talin Interactions

(2010) Nicholas J. Anthis et al.   STRUCTURE

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

Integrin-linked kinase associated with integrin activation

(2009) S. Honda et al.   BLOOD

Kindling the flame of integrin activation and function with kindlins

(2009) Edward F Plow et al.   CURRENT OPINION IN HEMATOLOGY

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

(2009) F. J. Conti et al.   DEVELOPMENT

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

(2009) Tong-Lay Lau et al.   EMBO JOURNAL

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

(2009) Emmanuel Debrand et al.   FEBS Journal

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of Integrin Binding to the Talin Rod

(2009) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin αIIbβ3 Activation in Chinese Hamster Ovary Cells and Platelets Increases Clustering Rather than Affinity

(2009) Thomas A. Bunch   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

(2009) Benjamin T. Goult et al.   JOURNAL OF MOLECULAR BIOLOGY

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration

(2009) Cai Huang et al.   NATURE CELL BIOLOGY

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

(2008) H. Takala et al.   BLOOD

Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle

(2008) F. J. Conti et al.   DEVELOPMENT

Identification of a repeated domain within mammalian α-synemin that interacts directly with talin

(2008) Ning Sun et al.   EXPERIMENTAL CELL RESEARCH

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

The Talin Rod IBS2 α-Helix Interacts with the β3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges

(2008) Sophie Rodius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin β Tails

(2008) Yatish Lad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Migfilin, a Molecular Switch in Regulation of Integrin Activation

(2008) Sujay Subbayya Ithychanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Cell adaptive response to extracellular matrix density is controlled by ICAP-1–dependent β1-integrin affinity

(2008) Angélique Millon-Frémillon et al.   JOURNAL OF CELL BIOLOGY

Quantification of integrin receptor agonism by fluorescence lifetime imaging

(2008) M. Parsons et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Interaction between the Cytoplasmic Domain of the Hyaluronate Receptor Layilin and the Talin F3 Subdomain

(2008) Kate L. Wegener et al.   JOURNAL OF MOLECULAR BIOLOGY

Differences in Regulation of Drosophila and Vertebrate Integrin Affinity by Talin

(2008) Teresa L. Helsten et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction

(2008) Siegfried Ussar et al.   PLoS Genetics