期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 8, 页码 1723-1728出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc2001227
关键词
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Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.
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