Nanotopography-based strategy for the precise manipulation of osteoimmunomodulation in bone regeneration

Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages

(2017) Zetao Chen et al.   Nanoscale

Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane

(2016) Kai Wang et al.   BIOMATERIALS

Neutrophils contribute to fracture healing by synthesizing fibronectin + extracellular matrix rapidly after injury

(2016) Okan W. Bastian et al.   CLINICAL IMMUNOLOGY

Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation

(2016) Xiao-qin Wu et al.   IMMUNOLOGY

Osteoimmunomodulation for the development of advanced bone biomaterials

(2016) Zetao Chen et al.   Materials Today

Tuning and predicting the wetting of nanoengineered material surface

(2016) M. Ramiasa-MacGregor et al.   Nanoscale

Modulating macrophage polarization with divalent cations in nanostructured titanium implant surfaces

(2016) Chung-Ho Lee et al.   NANOTECHNOLOGY

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

The Role of Surface Nanotopography and Chemistry on Primary Neutrophil and Macrophage Cellular Responses

(2016) Susan N. Christo et al.   Advanced Healthcare Materials

Nanopit-induced osteoprogenitor cell differentiation: The effect of nanopit depth

(2016) Martin J Davison et al.   Journal of Tissue Engineering

Ti nanorod arrays with a medium density significantly promote osteogenesis and osteointegration

(2016) Chengyun Ning et al.   Scientific Reports

Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

(2016) Carlos de Torre-Minguela et al.   Scientific Reports

The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry

(2016) Susan Christo et al.   Scientific Reports

Surface Chemical Gradient Affects the Differentiation of Human Adipose-Derived Stem Cells via ERK1/2 Signaling Pathway

(2015) Xujie Liu et al.   ACS Applied Materials & Interfaces

Materials Displaying Neural Growth Factor Gradients and Applications in Neural Differentiation of Embryoid Body Cells

(2015) Bahman Delalat et al.   ADVANCED FUNCTIONAL MATERIALS

T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone

(2015) Roberto Pacifici   Annals of the New York Academy of Sciences

Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10

(2015) Kazuki Fujioka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

(2015) Chengtie Wu et al.   BIOMATERIALS

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Controlled and sustained release of pharmaceuticals via single step solvent-free encapsulation

(2015) A. Cavallaro et al.   CHEMICAL COMMUNICATIONS

Plasma polymerised polyoxazoline thin films for biomedical applications

(2015) M. N. Ramiasa et al.   CHEMICAL COMMUNICATIONS

Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response

(2015) J. K. Chan et al.   EMBO Molecular Medicine

Hybrid core/shell microparticles and their use for understanding biological processes

(2015) Akash Bachhuka et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma

(2015) Oscar W.H. Yeung et al.   JOURNAL OF HEPATOLOGY

Effects of Different Lengths of Ti Nanorods Topography on Mesenchymal Stem Cell Growth and Proliferation

(2015) Xi Lin MD et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis

(2015) Kyle D. Phipps et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Focal bone involvement in inflammatory arthritis: the role of IL17

(2015) Maurizio Rossini et al.   RHEUMATOLOGY INTERNATIONAL

Protumoral TSP50 Regulates Macrophage Activities and Polarization via Production of TNF-α and IL-1β, and Activation of the NF-κB Signaling Pathway

(2015) Cheng Yang et al.   PLoS One

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

(2015) Yinpu Yue et al.   PLoS One

Multidirectional Effects of Sr-, Mg-, and Si-Containing Bioceramic Coatings with High Bonding Strength on Inflammation, Osteoclastogenesis, and Osteogenesis

(2014) Chengtie Wu et al.   ACS Applied Materials & Interfaces

Bioactive Silica Nanoparticles Promote Osteoblast Differentiation through Stimulation of Autophagy and Direct Association with LC3 and p62

(2014) Shin-Woo Ha et al.   ACS Nano

Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization

(2014) Qian-Li Ma et al.   BIOMATERIALS

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

Osteoimmunomodulatory properties of magnesium scaffolds coated with β-tricalcium phosphate

(2014) Zetao Chen et al.   BIOMATERIALS

Effects of anodic titanium dioxide nanotubes of different diameters on macrophage secretion and expression of cytokines and chemokines

(2014) W. L. Lü et al.   CELL PROLIFERATION

One-Dimensional Titanium Dioxide Nanomaterials: Nanotubes

(2014) Kiyoung Lee et al.   CHEMICAL REVIEWS

Human macrophage polarization in vitro: Maturation and activation methods compared

(2014) Daphne Y.S. Vogel et al.   IMMUNOBIOLOGY

Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury

(2014) Yohei Ikezumi et al.   PEDIATRIC NEPHROLOGY

A Mechanistic Study of the Plasma Polymerization of Ethanol

(2014) Hasan D. Hazrati et al.   Plasma Processes and Polymers

Osteoclasts: more than ‘bone eaters’

(2014) Julia F. Charles et al.   TRENDS IN MOLECULAR MEDICINE

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Nutrient element-based bioceramic coatings on titanium alloy stimulating osteogenesis by inducing beneficial osteoimmmunomodulation

(2014) Zetao Chen et al.   Journal of Materials Chemistry B

Mimicking Bone Nanostructure by Combining Block Copolymer Self-Assembly and 1D Crystal Nucleation

(2013) Xi Chen et al.   ACS Nano

Role of Interleukin-10 in Endochondral Bone Formation in Mice: Anabolic Effect via the Bone Morphogenetic Protein/Smad Pathway

(2013) Youn-Kwan Jung et al.   ARTHRITIS AND RHEUMATISM

Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model

(2013) Paula Hoff et al.   Cellular & Molecular Immunology

The Interplay between the Bone and the Immune System

(2013) Giorgio Mori et al.   Clinical & Developmental Immunology

Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone ResorptionIn VitroandIn Vivo

(2013) Hideki Kitaura et al.   Clinical & Developmental Immunology

Surface Immobilization of Engineered Nanomaterials for in Situ Study of their Environmental Transformations and Fate

(2013) Ryo Sekine et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of nanoporous alumina on inflammatory cell response

(2013) Shiuli Pujari et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Nanotopographical Effects on Mesenchymal Stem Cell Morphology and Phenotype

(2013) Penelope Tsimbouri et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Systemic inflammation induced by a thoracic trauma alters the cellular composition of the early fracture callus

(2013) Stefan Recknagel et al.   Journal of Trauma and Acute Care Surgery

Mimicking Nanofibrous Hybrid Bone Substitute for Mesenchymal Stem Cells Differentiation into Osteogenesis

(2013) Chinnasamy Gandhimathi et al.   MACROMOLECULAR BIOSCIENCE

Nanoengineered Plasma Polymer Films for Biomaterial Applications

(2013) Krasimir Vasilev   PLASMA CHEMISTRY AND PLASMA PROCESSING

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotopographical Cues Augment Mesenchymal Differentiation of Human Embryonic Stem Cells

(2013) Emmajayne Kingham et al.   Small

Small surface nanotopography encourages fibroblast and osteoblast cell adhesion

(2013) Renee V. Goreham et al.   RSC Advances

Nanotopography-mediated Reverse Uptake for siRNA Delivery into Neural Stem Cells to Enhance Neuronal Differentiation

(2013) Aniruddh Solanki et al.   Scientific Reports

2D and 3D Nanopatterning of Titanium for Enhancing Osteoinduction of Stem Cells at Implant Surfaces

(2013) Terje Sjöström et al.   Advanced Healthcare Materials

Functionality of Proteins Bound to Plasma Polymer Surfaces

(2012) Bryan R. Coad et al.   ACS Applied Materials & Interfaces

Effects of Hydroxyapatite-Containing Composite Nanofibers on Osteogenesis of Mesenchymal Stem Cells In vitro and Bone Regeneration In vivo

(2012) Lan-Xin Lü et al.   ACS Applied Materials & Interfaces

Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells

(2012) Weiqiang Chen et al.   ACS Nano

Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis

(2012) Nikolaus B. Binder et al.   ARTHRITIS AND RHEUMATISM

Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres

(2012) Matthias Bartneck et al.   BIOMATERIALS

Neural differentiation of mouse embryonic stem cells on conductive nanofiber scaffolds

(2012) Mahboubeh Kabiri et al.   BIOTECHNOLOGY LETTERS

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

The Temporal and Spatial Distribution of Macrophage Subpopulations During Arteriogenesis

(2012) C. Troidl et al.   Current Vascular Pharmacology

Electrospun bio-composite P(LLA-CL)/collagen I/collagen III scaffolds for nerve tissue engineering

(2012) Ewa Kijeńska et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Initial immune reaction and angiogenesis in bone healing

(2012) Katharina Schmidt-Bleek et al.   Journal of Tissue Engineering and Regenerative Medicine

Electrochemistry-enabled fabrication of orthogonal nanotopography and surface chemistry gradients for high-throughput screening

(2012) Lauren R. Clements et al.   LAB ON A CHIP

Immobilized Streptavidin Gradients as Bioconjugation Platforms

(2012) Bryan R. Coad et al.   LANGMUIR

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

New developments in osteoimmunology

(2012) Hiroshi Takayanagi   Nature Reviews Rheumatology

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

A substrate independent approach for generation of surface gradients

(2012) Renee V. Goreham et al.   THIN SOLID FILMS

Reduced in vitro immune response on titania nanotube arrays compared to titanium surface

(2012) Barbara S. Smith et al.   Biomaterials Science

Control of growth and inflammatory response of macrophages and foam cells with nanotopography

(2012) Mohammed Mohiuddin et al.   Nanoscale Research Letters

Biomimetic microtopography to enhance osteogenesis in vitro

(2011) Andrew Wilkinson et al.   Acta Biomaterialia

Advances in top–down and bottom–up surface nanofabrication: Techniques, applications & future prospects

(2011) Abhijit Biswas et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Effect of Electrospun Fiber Diameter and Alignment on Macrophage Activation and Secretion of Proinflammatory Cytokines and Chemokines

(2011) Enrica Saino et al.   BIOMACROMOLECULES

Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling

(2011) K.A. Daly et al.   BIOMATERIALS

Osteoimmunology: cytokines and the skeletal system

(2011) Seoung-Hoon Lee et al.   BMB Reports

The Biologics Anakinra and Etanercept Prevent Cytokine-Induced Growth Retardation in Cultured Fetal Rat Metatarsal Bones

(2011) Paola Fernandez-Vojvodich et al.   Hormone Research in Paediatrics

Plasma concentrations of pro- and anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients

(2011) Tiansheng Sun et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Effects of Interleukin-6 Ablation on Fracture Healing in Mice

(2011) Aaron Wallace et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Method for the Generation of Surface-Bound Nanoparticle Density Gradients

(2011) Renee V. Goreham et al.   Journal of Physical Chemistry C

In vitro and in vivo evaluation of the inflammatory response to nanoscale grooved substrates

(2011) Edwin Lamers et al.   Nanomedicine-Nanotechnology Biology and Medicine

Versatile gradients of chemistry, bound ligands and nanoparticles on alumina nanopore arrays

(2011) Andrew Michelmore et al.   NANOTECHNOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response

(2011) A. F. Malik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic effects of electrospun PLLA fiber dimension and pattern on neonatal mouse cerebellum C17.2 stem cells

(2010) Liumin He et al.   Acta Biomaterialia

Direct differentiation of human embryonic stem cells into selective neurons on nanoscale ridge/groove pattern arrays

(2010) Man Ryul Lee et al.   BIOMATERIALS

Contributions of surface topography and cytotoxicity to the macrophage response to zinc oxide nanorods

(2010) Toral D. Zaveri et al.   BIOMATERIALS

Controlled drug release from porous materials by plasma polymer deposition

(2010) Spomenka Simovic et al.   CHEMICAL COMMUNICATIONS

Multiple roles for CCR2 during fracture healing

(2010) Z. Xing et al.   Disease Models & Mechanisms

IL-1 plays an important role in the bone metabolism under physiological conditions

(2010) Y.-M. Lee et al.   INTERNATIONAL IMMUNOLOGY

Hemocompatibility of titania nanotube arrays

(2010) Barbara S. Smith et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Fabrication of micro/nano dual-scale structures by improved deep reactive ion etching

(2010) Guangyi Sun et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Nanotopographical modification: a regulator of cellular function through focal adhesions

(2010) Manus Jonathan Paul Biggs et al.   Nanomedicine-Nanotechnology Biology and Medicine

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Early Stages of Growth of Plasma Polymer Coatings Deposited from Nitrogen- and Oxygen-Containing Monomers

(2010) Krasimir Vasilev et al.   Plasma Processes and Polymers

Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells

(2009) Terje Sjöström et al.   Acta Biomaterialia

A role for γ/δ T cells in a mouse model of fracture healing

(2009) Nona T. Colburn et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering

(2009) Molamma P. Prabhakaran et al.   BIOMATERIALS

Tailoring the surface functionalities of titania nanotube arrays

(2009) Krasimir Vasilev et al.   BIOMATERIALS

Temporal pattern of gene expression and histology of stress fracture healing

(2009) L.J. Kidd et al.   BONE

Osteoimmunology: Crosstalk Between the Immune and Bone Systems

(2009) Tomoki Nakashima et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures

(2009) E. Van Goethem et al.   JOURNAL OF IMMUNOLOGY

Time-lapse observation of cell alignment on nanogrooved patterns

(2009) S. Fujita et al.   Journal of the Royal Society Interface

Deep reactive ion etching as a tool for nanostructure fabrication

(2009) Y. Q. Fu et al.   JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B

The fabrication of silicon nanostructures by local gallium implantation and cryogenic deep reactive ion etching

(2009) N Chekurov et al.   NANOTECHNOLOGY

Stem cell fate dictated solely by altered nanotube dimension

(2009) S. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TiO2Nanotube Surfaces: 15 nm-An Optimal Length Scale of Surface Topography for Cell Adhesion and Differentiation

(2009) Jung Park et al.   Small

Enhancing Osteogenic Differentiation of Mouse Embryonic Stem Cells by Nanofibers

(2009) Laura A. Smith et al.   TISSUE ENGINEERING PART A

Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-α and its possible role in wound healing

(2009) Xiaobing Fu et al.   WOUND REPAIR AND REGENERATION

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Osteoimmunology — The hidden immune regulation of bone

(2008) Caetano-Lopes J. et al.   AUTOIMMUNITY REVIEWS

Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering

(2008) Sangamesh G. Kumbar et al.   BIOMATERIALS

Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering

(2008) Yanzhong Zhang et al.   BIOMATERIALS

The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation

(2008) Lily Peng et al.   BIOMATERIALS

Surface Chemistry Influences Implant Biocompatibility

(2008) Liping Tang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways

(2008) Fumio Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased macrophage density on carbon nanotube patterns on polycarbonate urethane

(2008) Jong Youl Kim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Reactive Epoxy-Functionalized Thin Films by a Pulsed Plasma Polymerization Process

(2008) Benjamin Thierry et al.   LANGMUIR

A study on mRNA expressions of interleukin 10 during fracture healing for wound age determination

(2008) Masataka Takamiya et al.   Legal Medicine

Surface modification of nanoporous alumina membranes by plasma polymerization

(2008) Dusan Losic et al.   NANOTECHNOLOGY

Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation

(2008) D.C. Lacey et al.   OSTEOARTHRITIS AND CARTILAGE

Challenges and breakthroughs in recent research on self-assembly

(2008) Katsuhiko Ariga et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Tissue engineering with nano-fibrous scaffolds

(2008) Laura A. Smith et al.   Soft Matter

Enhancement of In Vitro Capillary Tube Formation by Substrate Nanotopography

(2007) C. J. Bettinger et al.   ADVANCED MATERIALS

The response of fibroblasts to hexagonal nanotopography fabricated by electron beam lithography

(2007) Matthew J. Dalby et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Inhibitory Effect of Interleukin-10 on Mouse Osteoclast Formation Involves Novel Tyrosine-Phosphorylated Proteins

(2006) Mei Hua Hong et al.   JOURNAL OF BONE AND MINERAL RESEARCH