Article
Engineering, Biomedical
Dainelys Guadarrama Bello, Patricia Moraille, Serine Boughari, Antonella Badia, Antonio Nanci
Summary: This study aims to investigate the biomechanical contribution of filopodia and their nanoprotrusions to the adhesive interaction of cells with nanostructured surfaces. The results show that surface topography can change the adhesive interaction of subcellular structures.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Multidisciplinary
Leonardo Raphael Zuardi, Fabiola Singaretti de Oliveira, Roger Rodrigo Fernandes, Maria Paula Oliveira Gomes, Silvia Spriano, Antonio Nanci, Paulo Tambasco de Oliveira
Summary: This study evaluates the effects of exogenous BMP-7 on the differentiation of osteoblastic cells on a nanotextured Ti surface. The results show that the concentration of BMP-7 can alter the differentiation of osteoblastic cells on different surfaces. However, on the nanotextured Ti surface, the effects of BMP-7 are limited and do not significantly increase the mineralized matrix production by differentiated osteoblasts.
Article
Engineering, Biomedical
Sadegh Ghorbani, Annette Christine Fuchtbauer, Andreas Mollebjerg, Pia Moller Martensen, Sara Hvidbjerg Laursen, David Christian Evar Kraft, Jorgen Kjems, Rikke Louise Meyer, Karim Rahimi, Morten Foss, Ernst-Martin Fuchtbauer, Duncan S. Sutherland
Summary: Biochemical and biomechanical signals in the niche environments regulate stem cell function. A study compared in vitro signals from LN-511 and/or topographic cues to maintain stemness in mESCs. The integration of LN-511 with nanotopography decreased colony growth but maintained stemness markers, suggesting the antagonistic effect of combining biochemical and topographic signals. Faster colony growth was observed at nanotopographies without LN-511, indicating improved ESC expansion.
Article
Multidisciplinary Sciences
A. Carrere, J. d'Alessandro, O. Cochet-Escartin, J. Hesnard, N. Ghazi, C. Riviere, C. Anjard, F. Detcheverry, J. -p. Rieu
Summary: This study discovers that living cells can spontaneously self-assemble into finite-sized domains, similar to the microphase separation in inert matter.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Multidisciplinary
Leonardo Raphael Zuardi, Cleide Lucia Araujo Silva, Eduardo Magalhaes Rego, Giovana Vacilotto Carneiro, Silvia Spriano, Antonio Nanci, Paulo Tambasco de Oliveira
Summary: In vitro study showed that titanium nanotopography modulates the osteogenic response and enhances the expression of alkaline phosphatase mRNA, activity, and osteopontin (OPN) levels. The presence of a blood clot tends to inhibit osteoblastic differentiation, but the coating of recombinant mouse (rm) BMP-7 on a nanostructured titanium surface promotes differentiation.
Editorial Material
Nanoscience & Nanotechnology
Kevin G. Yager
Summary: The self-assembly of a triblock bottlebrush polymer at one length scale determines the organization of the self-assembly at a smaller scale, creating a hierarchical unit cell.
NATURE NANOTECHNOLOGY
(2023)
Article
Materials Science, Coatings & Films
Iosif Vazirgiantzikis, Sarah Louise George, Luc Pichon
Summary: Surface modification of the implant surface with silver ion implantation reduces post-surgery infection rates. Different implantation dosages have little effect on the amount of stored silver. Polished surfaces have higher silver storage capacity. All studied conditions have the potential to be antimicrobial.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Daniel Salatto, Zhixing Huang, Peter Todd Benziger, Jan-Michael Y. Carrillo, Yashasvi Bajaj, Aiden Gauer, Leonidas Tsapatsaris, Bobby G. Sumpter, Ruipeng Li, Mikihito Takenaka, Wei Yin, David G. Thanassi, Maya Endoh, Tadanori Koga
Summary: Synergistic nanostructured surfaces combining bactericidal and bacteria-releasing properties were reported in this study. A diblock copolymer was used to fabricate vertically oriented cylindrical structures on silicon substrates. The results demonstrate that these surfaces exhibit highly effective bactericidal and bacteria-releasing properties against Escherichia coli and Listeria monocytogenes. Molecular dynamics simulations were performed to understand the mechanisms underlying these properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Mohd Irill Ishak, Marcus Eales, Laila Damiati, Xiayi Liu, Joshua Jenkins, Matthew J. Dalby, Angela H. Nobbs, Maxim G. Ryadnov, Bo Su
Summary: Nature-inspired antimicrobial surfaces and antimicrobial peptides are promising strategies to combat implant-associated infections. In this study, a bioinspired antimicrobial peptide was functionalized onto a nanospike surface, resulting in excellent antibacterial properties. The enhancement of bactericidal activity was achieved by rendering bacterial cell membranes more susceptible to nanospikes and increasing the surface area for antimicrobial peptide membrane insertion. These functionalized nanostructures show great potential as antibacterial implant surfaces due to their high biocompatibility with stem cells.
ACS APPLIED NANO MATERIALS
(2023)
Article
Cell Biology
Caiyun Wang, Shang Gao, Ran Lu, Xin Wang, Su Chen
Summary: The study suggests that hydrogenated superhydrophilic nanotubes modified titanium implants significantly accelerate bone growth and integration, with the Nano group also exhibiting enhanced osteogenesis at later stages, indicating high clinical potential.
Article
Chemistry, Physical
Tianqi Guo, Necla Asli Kocak Oztug, Pingping Han, Saso Ivanovski, Karan Gulati
Summary: Bioactivity of implants is influenced by the chemistry and topography of the surface, with nano-engineered implants often having concurrent modifications in both aspects. This study focused on how topography and chemistry of nanostructures affect protein adhesion and cell metabolism/proliferation, highlighting the significant impact of topography on cell alignment and bioactivity. The research aims to optimize parameters for the next generation of highly bioactive implants through a better understanding of the influence of dual topographically/chemically modified nano-engineered surfaces.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Laila A. Damiati, Monica P. Tsimbouri, Virginia-Llopis Hernandez, Vineetha Jayawarna, Mark Ginty, Peter Childs, Yinbo Xiao, Karl Burgess, Julia Wells, Mark R. Sprott, R. M. Dominic Meek, Peifeng Li, Richard O. C. Oreffo, Angela Nobbs, Gordon Ramage, Bo Su, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: This study developed a polymer coating with nano-topographical structure to support osteospecific stem cells and prevent bacterial adhesion and biofilm formation. The experimental results showed that this coating can increase cell adhesion and osteoblast differentiation, and reduce biofilm formation.
Article
Chemistry, Physical
Pingping Han, Tianqi Guo, Anjana Jayasree, Guillermo A. Gomez, Karan Gulati, Saso Ivanovski
Summary: Electrochemically engineered titania (Ti02) nanopores enable tailored cellular function; however, the cellular mechanosensing mechanisms dictating the cell response and soft tissue integration are yet to be elucidated. Here, we report the fabrication of anisotropic TiO2 nanopores with diameters of 46 and 66 nm on microrough titanium (Ti) via electrochemical anodization, towards short- and long-term guidance of human primary gingival fibroblasts (hGFs). These topographical-driven changes were attributed to the Ras-related C3 botulinum toxin substrate 1 (Rac 1) GTPase pathway and nuclear localisation of LAMIN NC and yes-associated protein (YAP) and associated with increased ligament differentiation with elevated expression of the ligament marker Mohawk homeobox (MKX).
Article
Chemistry, Physical
Pingping Han, Tianqi Guo, Anjana Jayasree, Guillermo A. Gomez, Karan Gulati, Saso Ivanovski
Summary: Electrochemically engineered titania (TiO2) nanopores were fabricated on rough titanium (Ti) to guide the growth of human primary gingival fibroblasts (hGFs) for short- and long-term. Results showed that nanopores with a diameter of 66 nm induced mature focal adhesions, encouraged actin fiber development, and led to elongated cell and nuclear shape. These changes were associated with the Rac 1 GTPase pathway, nuclear localization of LAMIN A/C and yes-associated protein (YAP), and increased expression of the ligament marker Mohawk homeobox (MKX). The study highlights the importance of nanopore diameter tuning in understanding intracellular and nuclear mechanotransduction and the interaction between nanomaterials and mechanoresponsive cellular elements.
Article
Chemistry, Physical
Tongwei Chen, Yunhan Zhang, Shiyan Xiao, Dongbao Yao, Wei Jiang, Haojun Liang
Summary: Obtaining a perfectly structured thin block copolymer film through self-assembly is challenging due to the system's tendency to be trapped in a metastable state. By employing dissipative particle dynamics (DPD), we investigated the self-assembly of AB symmetric diblock copolymers in a thin film. The introduction of a small molecule C as the third component allowed the system to avoid the metastable state, thereby correcting imperfect structures and promoting the formation of ordered structures. Similar to the role of a catalyst in catalytic chemistry, molecule C facilitated the assembly into an ordered structure while having less involvement within the polymer phase. Furthermore, simulation results highlighted the significance of the content of molecule C and its repulsive interactions with blocks A and B in effectively promoting assembly into ordered structures.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Kamakshi Bankoti, Arun Prabhu Rameshbabu, Sayanti Datta, Piyali Goswami, Madhurima Roy, Dipankar Das, Sudip Kumar Ghosh, Amit Kumar Das, Analava Mitra, Sagar Pal, Dhrubajyoti Maulik, Bo Su, Paulomi Ghosh, Bikramajit Basu, Santanu Dhara
Summary: The dual cross-linked CsADM-Cl hydrogel, modified with ionic crosslinking using chitosan and covalent crosslinking using an iodine-modified cross-linker, demonstrated improved stiffness and reduced biodegradation rate post-crosslinking. It supported adhesion, proliferation, and migration of human foreskin-derived fibroblasts and keratinocytes, exhibited angiogenic potential, showed excellent antibacterial activity, and promoted rapid healing in full thickness burn wounds with superior angiogenesis and other positive healing indicators. The bioactive CsADM-Cl hydrogel has significant clinical potential as an injectable antibacterial matrix for treating challenging burn wounds.
Article
Materials Science, Composites
Jing Ye, Huan Wang, Jiale Dong, Cheng Liu, Yan Gao, Bowen Gong, Bo Su, Hua-Xin Peng
Summary: A nano-scale electrochemical sculpture method called NES has been developed for creating TiO2 nanotube arrays on titanium sheets to enhance bonding with carbon fiber reinforced epoxy composites. Compared to other surface treatments, the optimized NES treatment showed the most significant improvement in shear strength between titanium and epoxy, indicating promise for applications in Fiber Metal Laminates.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Mohd I. Ishak, Illia Dobryden, Per Martin Claesson, Wuge H. Briscoe, Bo Su
Summary: Frictional and nanomechanical properties of nanostructured polymer surfaces play a crucial role in their applications. This study investigated the relationship between nanopillar height and friction coefficient, and found correlations between frictional instabilities and nanopillar density, pull-off force, and work of adhesion. The results suggest that multiparametric nanotribological analysis of nanostructured surfaces should go beyond classic Amontons' laws, with SSAC being more representative of the frictional properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Laila A. Damiati, Monica P. Tsimbouri, Virginia-Llopis Hernandez, Vineetha Jayawarna, Mark Ginty, Peter Childs, Yinbo Xiao, Karl Burgess, Julia Wells, Mark R. Sprott, R. M. Dominic Meek, Peifeng Li, Richard O. C. Oreffo, Angela Nobbs, Gordon Ramage, Bo Su, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: This study developed a polymer coating with nano-topographical structure to support osteospecific stem cells and prevent bacterial adhesion and biofilm formation. The experimental results showed that this coating can increase cell adhesion and osteoblast differentiation, and reduce biofilm formation.
Article
Dentistry, Oral Surgery & Medicine
Sana Algharaibeh, Hongbo Wan, Rami Al-Fodeh, Anthony J. Ireland, Dongsheng Zhang, Bo Su
Summary: Novel biomimetic ceramic/polymer composites with nacre-like microstructure were successfully fabricated and their mechanical properties were tested. The composite with 70% ceramic volume fraction exhibited sufficient strength, stiffness, and hardness, as well as remarkable fracture resistance. These materials show great potential as the next generation of CAD/CAM dental materials.
Article
Dentistry, Oral Surgery & Medicine
N. A. Ahmad Fauzi, A. J. Ireland, M. Sherriff, H. M. H. N. Bandara, B. Su
Summary: This study aimed to develop an aesthetic resin composite with antimicrobial properties using a nitrogen-doped titanium dioxide filler. The results showed that nitrogen-doped titanium dioxide released reactive oxygen species in the visible light spectrum, exhibiting good photocatalytic activity and antibacterial effect. Therefore, the N-TiO2 filled resin composite holds great promise as an ideal choice for orthodontic bonding.
Article
Materials Science, Composites
Jing Ye, Yan Gao, Yushan Wu, Cheng Liu, Jiale Dong, Huan Wang, Bo Su, Hua-Xin Peng
Summary: A new method called nano-scale electrochemical sculpture (NES) has been developed to enhance the bonding strength of fiber metal laminates (FMLs-NES). Through systematic investigation and comparison with traditional surface treatments, it has been found that FMLs-NES exhibits the smallest damage area and energy absorption, while maintaining structural integrity after impact. Finite element simulations have also provided insights into the impact damage progression and failure mechanisms, and the validated finite element model can be used to optimize the stacking sequence and predict residual strength after impact.
COMPOSITES SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Hongbo Wan, Nathanael Leung, Urangua Jargalsaikhan, Eric Ho, Chaolin Wang, Qiang Liu, Hua-Xin Peng, Bo Su, Tan Sui
Summary: Many natural materials provide inspiration for the development of lightweight composite materials with excellent damage tolerance. One example is the layered structure of nacre, which has significantly higher toughness than its component materials. By mimicking this structure and infiltrating metal into ceramic scaffolds, high-strength and high-toughness composites can be produced.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Composites
Jingyi Mo, Nathanael Leung, Urangua Jargalsaikhan, Hongbo Wan, Bin Zhu, Bo Su, Tan Sui
Summary: In this study, the mechanistic connection between microstructure and mechanical properties of a nacre-inspired composite material was investigated and addressed through quantifying phase-specific hardness, modulus, and residual stress. The findings demonstrated the potential of bioinspired synthetic architectures as a tuneable model system to investigate the design principles of more complex hierarchical biological materials.
COMPOSITES COMMUNICATIONS
(2022)
Article
Materials Science, Ceramics
Fausthon F. da Silva, Bo Su
Summary: This study reports the synthesis of TiO2/S-doped carbon nitride (TiO2/S-g-C3N4) heterojunctions using dual asymmetric centrifugation (DAC), and their performance in the photodegradation of rhodamine B (RhB). The optimized TiO2/S-g-C3N4 ratio was determined to be 1.0/0.1 w/w, and characterization data confirmed the formation of the heterojunction. The TiO2/S-g-C3N4 (1.0/0.1) heterojunction showed excellent photocatalytic performance, degrading 98.9% of RhB in 60 min under visible LED light, and acted via the Z-scheme mechanism as indicated by radical trapping experiments and VB-XPS spectra.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Aihua Yu, Ce Zhang, Wei Xu, Yun Zhang, Shiwei Tian, Bowen Liu, Jiazhen Zhang, Anrui He, Bo Su, Xin Lu
Summary: Porous Titanium scaffolds with multi-morphology structures were designed and fabricated in this study, showing excellent mechanical properties and cytocompatibility. Among them, PG50 exhibited similar elastic modulus to human bone and higher strength, providing potential for bone defect restoration.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Fausthon F. da Silva, Rodolfo B. da Silva, Thayse R. Silva, Daniel Araujo de Macedo, Bo Su
Summary: In this study, the influence of mass ratio on the photocatalytic performance of CN/ZnO heterojunctions was investigated, and it was found that the sample with a mass ratio of 2 exhibited the best photocatalytic activity.
SOLID STATE SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Mohd Irill Ishak, Marcus Eales, Laila Damiati, Xiayi Liu, Joshua Jenkins, Matthew J. Dalby, Angela H. Nobbs, Maxim G. Ryadnov, Bo Su
Summary: Nature-inspired antimicrobial surfaces and antimicrobial peptides are promising strategies to combat implant-associated infections. In this study, a bioinspired antimicrobial peptide was functionalized onto a nanospike surface, resulting in excellent antibacterial properties. The enhancement of bactericidal activity was achieved by rendering bacterial cell membranes more susceptible to nanospikes and increasing the surface area for antimicrobial peptide membrane insertion. These functionalized nanostructures show great potential as antibacterial implant surfaces due to their high biocompatibility with stem cells.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Ceramics
Eric Ho, Fabrizio Scarpa, Bo Su
Summary: Functionally-graded ceramic composites were produced using freeze casting method with varying solid loading and gelatine concentration, resulting in controlled microstructure and mechanical properties. Increasing solid loading and gelatine concentration improved compressive strength, with the best performance observed at 20% solid loading. Alumina/epoxy and alumina/aluminium composites showed significantly higher compressive strengths compared to their preform counterparts.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Engineering, Biomedical
Parinaz Tabrizian, Huijun Sun, Urangua Jargalsaikhan, Tan Sui, Sean Davis, Bo Su
Summary: The goal is to improve the bioactivity, incapability, and mechanical properties of bone implants by incorporating a nacre-like layered structure. This can enhance their mechanical strength, toughness, and durability, reducing the risk of implant failure. A bi-directional freeze-casting technique is used to produce nacre-like HA/polymer composites with high strength and fracture toughness.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
