Article
Immunology
Stephane Koda, Beibei Zhang, Qian-Yang Zhou, Na Xu, Jing Li, Ji-Xin Liu, Man Liu, Zi-Yan Lv, Jian-Ling Wang, Yanbiao Shi, Sijia Gao, Qian Yu, Xiang-Yang Li, Yin-Hai Xu, Jia-Xu Chen, B. Oneill Telakeng Tekengne, Gabriel K. Adzika, Ren-Xian Tang, Hong Sun, Kui-Yang Zheng, Chao Yan
Summary: This study reveals that beta 2-AR deficiency alleviates hepatobiliary damage in mice infected with C. sinensis by decreasing the activation and infiltration of M2 macrophages and reducing the production of type 2 cytokines associated with liver fibrosis. Furthermore, it shows that macrophages from Adrb2(-/-) mice exhibit decreased M2 markers and reduced ERK/mTORC1 phosphorylation compared to those from Adrb2(+/+), indicating the role of beta 2-AR in enhancing type 2 immune response through the ERK/mTORC1 signaling pathway in macrophages and their involvement in liver fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shaomin Gong, Shi Jin, Yang Li, Wuhua Jiang, Zhen Zhang, Ziyan Shen, Jialin Wang, Huili Zhou, Xiao Liu, Xialian Xu, Xiaoqiang Ding, Yiqin Shi, Hong Liu
Summary: The study found that higher levels of urinary sCD163 (u-sCD163) in patients with IgA nephropathy (IgAN) were associated with greater severity of histological lesions, more proteinuria, poorer renal function, and infiltration of tubulointerstitial CD163(+) macrophages. High u-sCD163 levels were also linked to a 2.66-fold greater risk for IgAN remission failure. Additionally, adding u-sCD163 levels to the model significantly improved the risk prediction of IgAN remission status.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Praneeth R. Kuninty, Karin Binnemars-Postma, Ahmed Jarray, Kunal P. Pednekar, Marcel A. Heinrich, Helen J. Pijffers, Hetty ten Hoopen, Gert Storm, Peter van Hoogevest, Wouter K. den Otter, Jai Prakash
Summary: In this study, engineered nanoliposomes mimic peroxidated phospholipids and specifically target tumor-associated macrophages. The nanoliposomes are efficiently taken up by M2 macrophages and can reduce premetastatic niche or tumor growth in vivo upon treatment with inhibitors or drugs.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Caigui Xiang, Chen Fan, Qiukai Lu, Moting Liu, Huimin Lu, Chunlan Feng, Yanwei Wu, Bing Wu, Heng Li, Wei Tang
Summary: Our study demonstrated that CSF-1R expression was increased in HDM-induced experimental asthma and inhibition of CSF-1R significantly affected the disease severity of asthma by suppressing allergic mediators secretion, airway epithelium dysfunction, and inflammatory cells infiltration. Furthermore, CSF-1R inhibitor could notably restrain the polarization and expression of transcriptional factors of alternatively activated macrophages (AAMs) induced by IL-4/IL-13 and reduce the recruitment of CSF1R-dominant macrophages in both acute and chronic allergic airway inflammation models.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jiqing Tang, Jun Liu, Qiaojuan Yan, Zhenglong Gu, Avery August, Weishan Huang, Zhengqiang Jiang
Summary: This study demonstrates that KMOS can ameliorate intestinal inflammation and improve intestinal immunity by modulating macrophage function in a SIGNR1-mediated pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nour Eissa, Omar Elgazzar, Hayam Hussein, Geoffrey N. Hendy, Charles N. Bernstein, Jean-Eric Ghia
Summary: The CHGA-derived peptide PST exacerbates the severity of ulcerative colitis by decreasing AAM functions and disrupting epithelial homeostasis, thus promoting the inflammatory process.
Article
Immunology
Federica Piattini, Mai Matsushita, Jonathan Muri, Peter Bretscher, Xiaogang Feng, Stefan Freigang, Jesmond Dalli, Christoph Schneider, Manfred Kopf
Summary: The study revealed that the conditional deletion of Gpx4 in specific myeloid cell lineages in mice did not affect the development and function of certain immune cells, but determined the sensitivity of tissue macrophages to lipid peroxidation and ferroptosis based on activation cues.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Rheumatology
Ranjan Gupta, Akhilesh Yadav, Amita Aggarwal
Summary: Urinary sCD163 is a promising biomarker for assessing disease activity in lupus nephritis, showing significantly higher levels in active LN patients and correlating with renal SLEDAI. In follow-up studies, urinary sCD163 levels decreased gradually in active LN patients and correlated with disease activity changes, suggesting its potential for monitoring disease progression.
CLINICAL RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Geou-Yarh Liou, Alicia K. Fleming Martinez, Heike R. Doppler, Ligia I. Bastea, Peter Storz
Summary: The M1 macrophages drive acinar-to-ductal metaplasia (ADM), while M2 macrophages contribute to lesion growth and fibrosis in pancreatic cancer initiation.
Article
Transplantation
Yuki Yokoe, Naotake Tsuboi, Takahiro Imaizumi, Akimitsu Kitagawa, Munetoshi Karasawa, Takaya Ozeki, Nobuhide Endo, Yuriko Sawa, Sawako Kato, Takayuki Katsuno, Shoichi Maruyama, Kunihiro Yamagata, Joichi Usui, Michio Nagata, Ken-Ei Sada, Hitoshi Sugiyama, Koichi Amano, Yoshihiro Arimura, Tatsuya Atsumi, Yukio Yuzawa, Hiroaki Dobashi, Yoshinari Takasaki, Masayoshi Harigai, Hitoshi Hasegawa, Hirofumi Makino, Seiichi Matsuo
Summary: The detection of leukocyte-derived CD11b and CD163 in urine may reflect renal inflammation in ANCA-GN, and CD11b at diagnosis can predict the recovery rate after the treatment of ANCA-GN.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Sujuan Xi, Xiaoyan Zheng, Xiangyong Li, Yuming Jiang, Yuankai Wu, Jiao Gong, Yusheng Jie, Zhanyi Li, Jing Cao, Liuping Sha, Min Zhang, Yutian Chong
Summary: The study revealed that the expression of M2 macrophage markers increases during liver fibrosis progression and is correlated with the severity of fibrosis. aHSCs recruit macrophages through the CCL2/CCR2 pathway and induce M2 phenotypic transformation.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Ye Li, Xinyao Chen, Lin Liu, Yunzi Chen, Xin Bi, Yuting Chen, Jialiang Zou, Zijue Wang, Ziqing Dong, Feng Lu
Summary: Macrophages play a significant role in tissue repair and can improve the retention rate of fat grafting by promoting vascularization and regeneration at the recipient site.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Rasmus Hvidbjerg Gantzel, Mikkel Breinholt Kjaer, Tea Lund Laursen, Konstantin Kazankov, Jacob George, Holger Jon Moller, Henning Gronbaek
Summary: Macrophages are crucial components of the human immune system, playing important roles in immune regulation and tissue repair. In liver diseases, they are involved in inflammation and fibrosis, with soluble CD163 and soluble mannose receptor potentially serving as promising biomarkers for assessing disease severity and predicting outcomes.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Pierre Chauvin, Claudie Morzadec, Bertrand de Latour, Francisco Llamas-Gutierrez, David Luque-Paz, Stephane Jouneau, Laurent Vernhet
Summary: This study found that M-MoDM and sCD163 levels in pulmonary tissues and alveolar fluids were elevated in IPF patients. However, serum sCD163 levels were not correlated with disease severity.
Article
Cell Biology
Gabriela E. Garcia, Yingjuan J. Lu, Luan D. Truong, Carlos A. Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Gabriel Cara-Fuentes, Ana Andres-Hernando, Miguel Lanaspa, Richard J. Johnson, Christopher P. Leamon
Summary: Targeting activated macrophages expressing FR beta with folate-linked drugs can be a selective approach for treating inflammatory diseases. The novel folic acid-aminopterin conjugate EC2319 showed significant kidney protection in anti-GBM glomerulonephritis through FR beta-mediated mechanisms, reducing macrophage infiltration and pro-inflammatory cytokine expression.
Article
Biochemistry & Molecular Biology
Khai Gene Leong, Elyce Ozols, John Kanellis, David J. Nikolic-Paterson, Frank Y. Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Anatomy & Morphology
Dan Wang, Jiayi Yang, Jinjin Fan, Wei Chen, David J. Nikolic-Paterson, Jinhua Li
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Khai Gene Leong, Elyce Ozols, John Kanellis, Shawn S. Badal, John T. Liles, David J. Nikolic-Paterson, Frank Y. Ma
Summary: The study demonstrated that the selective cyclophilin inhibitor GS-642362 effectively protected against acute kidney injury and renal fibrosis in mouse models. The treatment reduced cell death, inflammatory cell infiltration, and fibrosis, supporting further investigation of cyclophilin blockade in various kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tyrone L. R. Humphries, Kunyu Shen, Abishek Iyer, David W. Johnson, Glenda C. Gobe, David Nikolic-Paterson, David P. Fairlie, David A. Vesey
Summary: Coagulopathies in patients with diabetes and CKD are not fully understood. This study found that glucose availability affects TF synthesis in HTECs through PAR2 activation, and high glucose concentrations enhance this process while inhibiting PAR2, glycolysis, or glycosylation suppresses TF synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Ana B. Nunez-Nescolarde, David J. Nikolic-Paterson, Alexander N. Combes
Summary: Kidney organoids and tubuloids are suitable models for studying kidney diseases and can help elucidate the pathogenic mechanisms, but their use in complex diseases is still in the early stages.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Pathology
Keren Grynberg, Lifang Tian, Greg Tesch, Elyce Ozols, William R. Mulley, David J. Nikolic-Paterson, Frank Y. Ma
Summary: This study found that mice with established diabetes were more susceptible to acute kidney injury (AKI) associated with renal ischemia/reperfusion injury (IRI). The researchers identified JNK and SYK as potential therapeutic targets for anticipated AKI in patients with diabetes.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Endocrinology & Metabolism
Lingyun Kong, Sofianos Andrikopoulos, Richard J. MacIsaac, Laura K. Mackay, David J. Nikolic-Paterson, Niloufar Torkamani, Neda Zafari, Evelyn C. S. Marin, Elif Ekinci
Summary: Diabetic kidney disease (DKD) is a prevalent complication of diabetes and a leading cause of end-stage kidney disease. Inflammation plays a crucial role in the progression of DKD, with the adaptive immune system potentially contributing to the disease development. Targeting the adaptive immune system, specifically T cells, may have therapeutic benefits in preventing the progression of DKD.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Food Science & Technology
Khai Gene Leong, Elyce Ozols, John Kanellis, Frank Y. Ma, David J. Nikolic-Paterson
Summary: The study found that Cyclophilin D (CypD) facilitates aristolochic acid-induced acute kidney injury, but does not contribute to the transition from acute kidney injury to chronic kidney disease during ongoing exposure to aristolochic acid.
Editorial Material
Physiology
Patrick Ming-Kuen Tang, Haiyong Chen, Ying Tang, David J. Nikolic-Paterson, Hui Yao Lan
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
James van der Wolde, Kotaro Haruhara, Victor G. Puelles, David Nikolic-Paterson, John F. Bertram, Luise A. Cullen-McEwen
Summary: This study investigated the progressive loss of podocytes during healthy aging and how the remaining podocytes respond to podocyte depletion at different ages. The results showed that podocyte number per glomerulus did not change in control mice during the examined time period but control mice at 18 months had the largest podocytes and the lowest podocyte density. Podocyte depletion at different ages resulted in different levels of albuminuria and glomerulosclerosis. In addition, the study found that the mTORC1-mediated podocyte hypertrophy played an important role in both physiological aging and adaptive settings.
CELL AND TISSUE RESEARCH
(2022)
Article
Genetics & Heredity
Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David JNikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam, Paul J. Lockhart
Summary: Aminoglycoside antibiotics can cause toxic effects on the sensory hair cells in the inner ear, leading to permanent hearing loss and vestibular impairment. This study investigates the potential of ASK1 inhibition as a novel strategy to prevent aminoglycoside ototoxicity, providing significant pre-clinical evidence.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Correction
Genetics & Heredity
Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David J. Nikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam, Paul J. Lockhart
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Pediatrics
Yohei Ikezumi, Masatoshi Yoshikane, Tomomi Kondoh, Yuji Matsumoto, Naonori Kumagai, Masahiro Kaneko, Hiroya Hasegawa, Takeshi Yamada, Toshiaki Suzuki, David J. Nikolic-Paterson
Summary: This study showed that mizoribine can slow down the progression of kidney fibrosis in childhood IgA nephropathy by reducing the number of specific macrophage populations associated with fibrosis.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jinhua Li, Xinli Qu, Chengnong Guan, Ning Luo, Huiting Chen, Andy Li, Hongjie Zhuang, Jiayi Yang, Hui Diao, Shuhan Zeng, Qing Wang, Jinjin Fan, Mengjie Jiang, Xiaoyan Bai, Zhiming Ye, Xiaoyun Jiang, Wei Chen, David J. Nikolic-Paterson, Xueqing Yu
Summary: Progressive fibrosis is a characteristic of chronic kidney disease, but effective treatments are lacking. The micropeptide regulator of b-oxidation (MOXI) is found to regulate kidney fibrosis. MOXI expression is up-regulated in human fibrotic kidney disease, and its deletion protects mice against fibrosis and inflammation. Antisense MOXI oligonucleotide treatment effectively reduces MOXI expression and protects against kidney fibrosis.
KIDNEY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: In this study, the researchers found that phenotype and function of tumor-associated neutrophils (TANs) are influenced by the microenvironment, resulting in different impact on tumor development as N1 or N2 state. They discovered that Smad3 activation is negatively correlated with N2 state and patient survival in NSCLC patients. In preclinical lung cancer models, targeting Smad3 reprogrammed TANs to an antitumor state (N1), suppressing tumor growth. Mechanistically, Smad3 regulated the maturity of TANs and maintained the N2 state through controlling genes related to cell fate determination. Thus, the findings suggest that Smad3 signaling could be a therapeutic target for cancer immunotherapy.
NATURE COMMUNICATIONS
(2023)