Studies for Improving a Rat Model of Alzheimer’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory

Mouse Models of Alzheimer’s Disease

(2017) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice

(2017) Jürgen Götz et al.   JOURNAL OF ALZHEIMERS DISEASE

Opportunities and challenges in developing relevant animal models for Alzheimer’s disease

(2016) Fernanda G. De Felice et al.   AGEING RESEARCH REVIEWS

Toward more predictive genetic mouse models of Alzheimer's disease

(2016) Kristen D. Onos et al.   BRAIN RESEARCH BULLETIN

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

(2016) Francesco Simone Ruggeri et al.   CURRENT PHARMACEUTICAL DESIGN

M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-β-Treated Rats Through Regulation of Microglial Polarization

(2016) Dan Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Genes associated with Alzheimer's disease: an overview and current status

(2016) Mohan Giri et al.   Clinical Interventions in Aging

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits

(2016) Hye Yun Kim et al.   Jove-Journal of Visualized Experiments

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

(2014) Ana Catarina Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Animal models of Alzheimer disease: historical pitfalls and a path forward

(2014) Sarah E. Cavanaugh   ALTEX-Alternatives to Animal Experimentation

Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

(2014) Jan Klohs et al.   Frontiers in Aging Neuroscience

Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

(2014) Jesse S. O. Lindholm et al.   Frontiers in Behavioral Neuroscience

Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42to the Rat Brain

(2014) Emőke Borbély et al.   Biomed Research International

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy

(2013) Mark Halliday et al.   NEUROPHARMACOLOGY

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Spatial learning-related changes in metabolic activity of limbic structures at different posttask delays

(2012) M. Méndez-López et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Genetic insights in Alzheimer's disease

(2012) Karolien Bettens et al.   LANCET NEUROLOGY

Aβ Toxicity in Alzheimer's Disease

(2012) Virve Cavallucci et al.   MOLECULAR NEUROBIOLOGY

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice

(2012) Ajeet Rijal Upadhaya et al.   NEUROBIOLOGY OF AGING

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Time-Course and Regional Analyses of the Physiopathological Changes Induced after Cerebral Injection of an Amyloid β Fragment in Rats

(2011) Charleine Zussy et al.   AMERICAN JOURNAL OF PATHOLOGY

Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1–42)

(2011) Fu-Qian He et al.   BRAIN RESEARCH

First transgenic rat model developing progressive cortical neurofibrillary tangles

(2011) Peter Filipcik et al.   NEUROBIOLOGY OF AGING

Kainate postconditioning restores LTP in ischemic hippocampal CA1: Onset-dependent second pathophysiological stress

(2011) Dávid Nagy et al.   NEUROPHARMACOLOGY

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Genistein ameliorates learning and memory deficits in amyloid β(1–40) rat model of Alzheimer’s disease

(2010) Maryam Bagheri et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Aβ peptides in mouse models of Alzheimer's disease

(2009) Ditte Z. Christensen et al.   BRAIN RESEARCH

Validation of Aβ1–40 administration into mouse cerebroventricles as an animal model for Alzheimer disease

(2009) Shuko Takeda et al.   BRAIN RESEARCH

Intranasal Delivery of Human β-Amyloid Peptide in Rats: Effective Brain Targeting

(2009) Eszter Sipos et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Controlled in situ preparation of Aβ(1–42) oligomers from the isopeptide “iso-Aβ(1–42)”, physicochemical and biological characterization

(2009) Zsolt Bozso et al.   PEPTIDES

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH