Review
Biochemistry & Molecular Biology
Bhagavathi Sundaram Sivamaruthi, Neha Raghani, Mehul Chorawala, Sankha Bhattacharya, Bhupendra G. Prajapati, Gehan M. Elossaily, Chaiyavat Chaiyasut
Summary: The NF-kappa B pathway plays a crucial role in various diseases, including Alzheimer's disease. It has the potential to mitigate neuroinflammation, modulate amyloid beta production, and promote neuronal survival in the progression of Alzheimer's disease. However, there are limitations and challenges associated with this approach, as balancing inflammation inhibition and preserving physiological immune responses is critical.
Article
Nutrition & Dietetics
Shanshan Chen, Honghan Liu, Shimiao Wang, Hongbo Jiang, Le Gao, Lu Wang, Lesheng Teng, Chunyue Wang, Di Wang
Summary: The neuroprotective mechanism of Verbascoside (VB) was explored in this study. Proteomic analysis and immunological methods revealed that VB exerts its neuroprotective effect by inhibiting neuroinflammation and modulating the NF-kappa B-p65 pathway. These findings suggest that VB could be a potential candidate drug for the prevention and treatment of Alzheimer's disease (AD).
Article
Neurosciences
Yue Zhang, Jianping Jia
Summary: In this study, betaine was found to inhibit AβO-induced neuroinflammation in microglia by suppressing the activation of the NLRP3 inflammasome and NF-κB, suggesting its potential as an effective modulator for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Li He, Jinxia Sun, Zhulei Miao, Shengmin Chen, Guizhen Yang
Summary: The inflammatory process plays a significant role in the pathophysiology of Alzheimer's disease (AD). Astragaloside IV (AS-IV), a saponin of Astragali radix, has shown significant anti-inflammatory properties and protective effects against neurodegenerative diseases. AS-IV can reduce the expression of inflammatory factors and improve cognitive function in AD.
Review
Cell Biology
Tiantian Li, Li Lu, Eloise Pember, Xinuo Li, Bocheng Zhang, Zheying Zhu
Summary: This review highlights new insights into the role of neuroinflammation in the pathogenesis of Alzheimer's disease, including the involvement of biomarkers such as NF-kappa B, NLRP3, TREM2, and cGAS-STING. It also provides an overview of novel treatments based on these biomarkers as potential drug targets.
Article
Biochemistry & Molecular Biology
Buyun Kim, Ki Yong Lee, Byoungduck Park
Summary: Alzheimer's disease is a severe neurodegenerative disorder characterized by distinct pathological features. The nuclear factor-κB plays a crucial role in neuronal inflammation. Isoorientin (ISO) shows potential as a promising therapeutic drug candidate for the treatment and prevention of AD.
Article
Microbiology
Zheng Chen, Zikai Zhao, Yixin Liu, Muhammad Imran, Jing Rao, Ning Cai, Jing Ye, Shengbo Cao
Summary: This study revealed the role of NOD1 in Japanese encephalitis virus (JEV)-induced neuroinflammation. Activation of NOD1 enhanced the neuroinflammatory response in both in vivo and in vitro models of JEV infection. Inhibition of NOD1 significantly abrogated the inflammatory response triggered by JEV infection. Moreover, NOD1 knockout mice showed resistance to JEV infection. The NOD1-mediated neuroinflammatory response was associated with the activation/phosphorylation of downstream signaling molecules.
MICROBIOLOGY SPECTRUM
(2022)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Yaping Guo, Mingna Sun, Li Li, Wenbin He
Summary: This study found that chrysin, a natural flavonoid compound, can alleviate neuroinflammation and depressive-like behaviors induced by chronic stress by inhibiting the activation of Fyn and NF-κB pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Yi-Chun Chen, Shih-Cheng Chang, Yun-Shien Lee, Wei-Min Ho, Yu-Hua Huang, Yah-Yuan Wu, Yi-Chuan Chu, Kuan-Hsuan Wu, Li-Shan Wei, Hung-Li Wang, Ching-Chi Chiu
Summary: This study identified six variants of the TOMM40 gene in Taiwanese AD patients using next-generation sequencing, and found that two variants (rs157581 and rs11556505) were associated with increased AD risk. Cell models experiments further showed that these variants caused mitochondrial dysfunction, microglial activation, and neuroinflammation. In addition, AD patients carrying these variants exhibited elevated levels of inflammatory cytokines in plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fengmao An, Xinran Xuan, Zheng Liu, Ming Bian, Qingkun Shen, Zheshan Quan, Guowei Zhang, Chengxi Wei
Summary: In this study, the potential of a compound called W112 for the treatment of Alzheimer's disease (AD) was investigated. The results showed that W112 has neuroprotective effects against AD-like pathology, improving learning and memory abilities in AD-induced rats and reversing tau hyperphosphorylation. It also reduced the production of proinflammatory cytokines in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Ihab M. M. Abdallah, Kamal M. M. Al-Shami, Amer E. E. Alkhalifa, Nour F. F. Al-Ghraiybah, Claudia Guillaume, Amal Kaddoumi
Summary: This study compared the beneficial effects of different doses of OC-low EVOO and OC on A beta and related pathology as well as neuroinflammation in 5xFAD mice. The results showed that 0.5 mg/kg EVOO-phenols and OC reduced brain A beta levels and neuroinflammation by suppressing the NF-kappa B pathway and inhibiting the activation of NLRP3 inflammasomes. However, only OC suppressed the RAGE/HMGB1 pathway. In conclusion, dietary supplementation with EVOO or OC can prevent, halt progression, and treat AD.
Article
Chemistry, Medicinal
Shiquan Chang, Xin Li, Yachun Zheng, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Guoqiang Qian, Guoping Zhao
Summary: This research demonstrates that kaempferol has anti-inflammatory and analgesic effects, potentially through modulating microglial polarization and inhibiting the TLR4/NF-kappa B signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jingjie Sun, Xiaodong Qin, Xinyan Zhang, Qi Wang, Wei Zhang, Manxia Wang
Summary: The study found that FBXW11 may regulate neuroinflammation in Alzheimer's disease (AD) by suppressing the NF-kappa B signaling pathway. Through interaction with ASK1, FBXW11 promotes its ubiquitination, leading to aberrant activation of the NF-kappa B and MAPK signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biology
Dongyang Wang, Xiaojing Zheng, Lihong Chai, Junli Zhao, Jiuling Zhu, Yanqing Li, Peiyan Yang, Qinwen Mao, Haibin Xia
Summary: In this study, the role of FAM76B in regulating neuroinflammation was demonstrated for the first time. It was shown that FAM76B could regulate the NF-kappa B-mediated inflammatory pathway by affecting hnRNPA2B1 translocation. This provides new insights into the mechanism of inflammation regulation.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.