Review
Neurosciences
Benedetta Storti, Maria Magdalena Gabriel, Stefan Sennfaelt, Isabella Canavero, Nicola Rifino, Laura Gatti, Anna Bersano
Summary: Thanks to improved knowledge and diagnostic techniques, the clinical spectrum of cerebral amyloid angiopathy (CAA) is now broader and includes sporadic CAA, hereditary CAA, CAA-related inflammation (CAA-ri), and iatrogenic CAA (iCAA). CAA-ri, an aggressive subtype with vascular inflammation, has gained attention due to the efficacy of anti-inflammatory drugs. There is increasing scientific interest in an atypical variant of iCAA. This brief review aims to increase awareness and understanding of these rare forms of CAA.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Benedetta Storti, Isabella Canavero, Maria Magdalena Gabriel, Antonella Capozza, Nicola Rifino, Mario Stanziano, Luca Tagliabue, Anna Bersano
Summary: Iatrogenic cerebral amyloid angiopathy (iCAA) is a specific type of cerebral amyloid angiopathy, and its diagnosis is increasing. It is hypothesized that iCAA may occur as a late consequence of past neurosurgical interventions involving dural patch grafts. Although positron emission tomography (PET) scans and beta-amyloid levels in cerebrospinal fluid (CSF) are auxiliary criteria, the definite diagnosis still relies on histopathological examination.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Mo-Kyung Sin, Edward Zamrini, Ali Ahmed, Kwangsik Nho, Ihab Hajjar
Summary: Anti-amyloid therapies (AATs) are emerging treatments for early Alzheimer's disease (AD). However, they may cause abnormal signals in the brain, known as amyloid-related imaging abnormalities (ARIA). Cerebral amyloid angiopathy (CAA) is a major risk factor for ARIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Xiaofang Xu, Huikang Xu, Zhaocai Zhang
Summary: Cerebral amyloid angiopathy (CAA) is a disease characterized by the deposition of amyloid beta (A beta) and other amyloid proteins in the brain's blood vessels, leading to cerebrovascular and brain damage. CAA is often associated with cardiac injury, involving A beta, tau, and transthyroxine amyloid (ATTR). A beta acts as the main damaging factor, causing coronary artery atherosclerosis, aortic valve calcification, and cardiomyocyte degeneration. The progression of CAA can further impact the heart through amyloidosis, inflammation, and cerebral hemorrhage. The interaction between CAA and cardiac injury creates a vicious cycle that accelerates the progression of both conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Tsuyoshi Hamaguchi, Kenjiro Ono, Masahito Yamada
Summary: Deposition of amyloid beta protein in the brain is a characteristic of Alzheimer's disease, which can be transmitted between individuals through a prion-like mechanism. Pathological studies have shown that patients with iatrogenic Creutzfeldt-Jakob disease, caused by medical procedures such as human growth hormone injection and dura mater graft, also have cerebral amyloid beta protein deposition. Additionally, young patients with cerebral amyloid angiopathy-related cerebral hemorrhage, who have undergone neurosurgeries with or without dura mater graft in early childhood, suggest that the transmission of cerebral amyloid beta protein pathology is often through amyloid angiopathy rather than parenchymal deposition.
NEUROCHEMICAL RESEARCH
(2022)
Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Biochemistry & Molecular Biology
E. A. Lysikova, E. V. Kuzubova, A. I. Radchenko, E. A. Patrakhanov, K. D. Chaprov, M. V. Korokin, A. V. Deykin, O. S. Gudyrev, M. V. Pokrovskii
Summary: Alzheimer's disease (AD) is characterized by a decrease in cognitive functions and the accumulation of amyloid plaques in the brain. Rats and mice do not develop AD-like pathology, but transgenic mice overexpressing human amyloid beta (Aβ) can be used as a model. The APPswe/PS1dE9/Blg mouse line is a convenient model for studying AD and developing therapeutic strategies.
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Chemistry, Multidisciplinary
E. Ruifang, Yaling Shi, Weiwei Wang, Ming Qi
Summary: This study investigated the mechanism by which callistephin mitigates the formation of A beta aggregation and associated CAA, showing that callistephin inhibits A beta fibrillization and reduces cytotoxicity against CVSMCs. These findings suggest potential protective effects of callistephin against CAA through regulation of membrane leakage and downregulation of inflammatory proteins.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Clinical Neurology
Jhih-Yong Yang, Yung-Tsai Chu, Hsin-Hsi Tsai, Jiann-Shing Jeng
Summary: This study retrospectively described two cases of CAA-ri and investigated the longitudinal changes of amyloid PET. The results showed focal decreases in amyloid load after the inflammatory process. The study also revealed variable findings related to amyloid burden in post-inflammatory regions in previously reported cases of CAA-ri with available amyloid PET.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada
Summary: The study found that exogenous A beta seeds from different A beta pathologies induced A beta deposition in the blood vessels rather than the brain parenchyma, which might be the predominant feature of A beta pathology in iatrogenic transmission cases; Contamination of brain tissues from patients with little A beta pathology could lead to iatrogenic transmission of A beta pathology, emphasizing the urgent need for the development of inactivation methods to prevent such transmission.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Joseph M. Schrader, Feng Xu, William E. Van Nostrand
Summary: Cerebral amyloid angiopathy (CAA) is a prevalent cerebral small vessel disease in the elderly and is often comorbid with Alzheimer's disease. This study investigated proteome changes associated with specific pathological features in different brain regions of rTg-DI rats, a preclinical model of CAA. The results showed varying levels of CAA and associated pathologies in different brain regions, with specific molecular pathways implicated in each region.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, General & Internal
Anna Olczak, Aleksandra Truszczynska-Baszak, Katarzyna Gniadek-Olejniczak
Summary: The study analyzed the static and dynamic balance of the body and changes in the tension of selected muscles of the cervical spine in patients with CAA after stroke. It was found that the LC muscle was significantly more active in static tests and MOS showed significantly higher results in dynamic tests. The more functional deficits, the more difficult it is to keep balance.
Article
Neurosciences
Chih-Hao Chen, Mary Klir Khnaijer, Andrew E. Beaudin, Cheryl R. McCreary, Myrlene Gee, Feryal Saad, Richard Frayne, Zahinoor Ismail, G. Bruce Pike, Richard Camicioli, Eric E. Smith
Summary: In this study, researchers investigated whether cerebral amyloid angiopathy (CAA) is associated with subcortical atrophy. They found that CAA patients did not show substantial atrophy of subcortical volumes compared to Alzheimer's disease (AD) or healthy controls, except for the putamen. Differences in findings may be due to heterogeneity in CAA presenting syndromes or severity.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Nicolau Beckmann, Arno Doelemeyer, Stefan Zurbruegg, Karine Bigot, Diethilde Theil, Wilfried Frieauff, Carine Kolly, Pierre Moulin, Daniel Neddermann, Robert Kreutzer, Ludovic Perrot, Irena Brzak, Laura H. Jacobson, Matthias Staufenbiel, Ulf Neumann, Derya R. Shimshek
NEUROBIOLOGY OF AGING
(2016)
Article
Neurosciences
Mehtap Bacioglu, Luis F. Maia, Oliver Preische, Juliane Schelle, Anja Apel, Stephan A. Kaeser, Manuel Schweighauser, Timo Eninger, Marius Lambert, Andrea Pilotto, Derya R. Shimshek, Ulf Neumann, Philipp J. Kahle, Matthias Staufenbiel, Manuela Neumann, Walter Maetzler, Jens Kuhle, Mathias Jucker
Article
Multidisciplinary Sciences
Derya R. Shimshek, Laura H. Jacobson, Carine Kolly, Natasa Zamurovic, Kamal Kumar Balavenkatraman, Laurent Morawiec, Robert Kreutzer, Juliane Schelle, Mathias Jucker, Barbara Bertschi, Diethilde Theil, Annabelle Heier, Karine Bigot, Karen Beltz, Rainer Machauer, Irena Brzak, Ludovic Perrot, Ulf Neumann
SCIENTIFIC REPORTS
(2016)
Article
Geriatrics & Gerontology
Giovanna D. Ielacqua, Felix Schlegel, Martina Fuechtemeier, Jael Xandry, Markus Rudin, Jan Klohs
FRONTIERS IN AGING NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Zohreh Hosseinzadeh, Yogesh Singh, Derya R. Shimshek, Herman van der Putten, Carsten A. Wagner, Florian Lang
SCIENTIFIC REPORTS
(2017)
Article
Clinical Neurology
Markus Vaas, Andreas Deistung, Juergen R. Reichenbach, Annika Keller, Anja Kipar, Jan Klohs
TRANSLATIONAL STROKE RESEARCH
(2018)
Article
Neurosciences
Derya R. Shimshek, Thorsten Bus, Bettina Schupp, Vidar Jensen, Verena Marx, Liliana E. Layer, Georg Koehr, Rolf Sprengel
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Neurosciences
Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S. Mabrouk, Robert T. Kennedy, Derya R. Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio, Michele Morari
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2017)
Article
Neurosciences
Kaichuan Zhu, Xianyuan Xiang, Severin Filser, Petar Marinkovic, Mario M. Dorostkar, Sophie Crux, Ulf Neumann, Derya R. Shimshek, Gerhard Rammes, Christian Haass, Stefan F. Lichtenthaler, Jenny M. Gunnersen, Jochen Herms
BIOLOGICAL PSYCHIATRY
(2018)
Article
Cell Biology
Arina Riabinska, Marietta Zille, Menderes Yusuf Terzi, Ryan Cordell, Melina Nieminen-Kelhae, Jan Klohs, Ana Luisa Pina
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)
Correction
Cell Biology
Arina Riabinska, Marietta Zille, Menderes Yusuf Terzi, Ryan Cordell, Melina Nieminen-Kelhae, Jan Klohs, Ana Luisa Pina
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruiqing Ni, Yvette Zarb, Gisela A. Kuhn, Ralph Muller, Yankey Yundung, Roger M. Nitsch, Luka Kulic, Annika Keller, Jan Klohs
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan Klohs, Ann M. Hirt
Summary: The study compared the magnetic susceptibility and water content of fresh and chemically fixed mouse tissue, revealing heart tissue to be more diamagnetic than other tissues. Fixed tissue showed less diamagnetic susceptibility compared to fresh tissue, with no consistent change in water content.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Endocrinology & Metabolism
Diana Kindler, Cinzia Maschio, Ruiqing Ni, Valerio Zerbi, Daniel Razansky, Jan Klohs
Summary: The study found no significant differences in regional cerebral blood flow between P301L mice and non-transgenic littermates at different disease stages, indicating that hypoperfusion and neurodegeneration are not phenotypes of P301L mice. Additional research is needed to further understand the relationship between tau, neurodegeneration, vascular dysfunction, and modulators in Alzheimer's disease and primary tauopathies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Juliane Schelle, Lisa M. Haesler, Jens C. Goepfert, Thomas O. Joos, Hugo Vanderstichele, Erik Stoops, Eva-Maria Mandelkow, Ulf Neumann, Derya R. Shimshek, Matthias Staufenbiel, Mathias Jucker, Stephan A. Kaeser
ALZHEIMERS & DEMENTIA
(2017)