Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor

Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

(2017) Gino Van Heeke et al.   PHARMACOLOGY & THERAPEUTICS

High-efficiency antibody discovery achieved with multiplexed microscopy

(2016) Shelley Mettler Izquierdo et al.   Microscopy

Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif

(2015) Du-San Baek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors

(2015) Arnau Cordomí et al.   BIOCHEMICAL PHARMACOLOGY

Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms

(2015) Yasmina Noubia Abdiche et al.   mAbs

Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice

(2015) V. Pathak et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

(2015) Sue Townsend et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

(2015) Maarten Van Roy et al.   ARTHRITIS RESEARCH & THERAPY

A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation

(2015) Philip A. Leighton et al.   Frontiers in Immunology

Monoclonal antibody binding-site diversity assessment with a cell-based clustering assay

(2014) Sindy Liao-Chan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

High-Throughput Epitope Binning Assays on Label-Free Array-Based Biosensors Can Yield Exquisite Epitope Discrimination That Facilitates the Selection of Monoclonal Antibodies with Functional Activity

(2014) Yasmina Noubia Abdiche et al.   PLoS One

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

(2013) Peter Ravn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal antibody disulfide reduction during manufacturing

(2013) Katariina M. Hutterer et al.   mAbs

Harnessing Gene Conversion in Chicken B Cells to Create a Human Antibody Sequence Repertoire

(2013) Benjamin Schusser et al.   PLoS One

Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells

(2013) B. Schusser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the structure of class B GPCRs

(2013) Kaspar Hollenstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

(2012) Kuntal Pal et al.   ACTA PHARMACOLOGICA SINICA

Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity

(2012) Yasmina N. Abdiche et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide

(2011) Kalyana C. Venneti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans

(2011) M. Christensen et al.   DIABETES

Epitope binning of murine monoclonal antibodies by a multiplexed pairing assay

(2011) Paul L. Miller et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids

(2011) L. Wu et al.   JOURNAL OF IMMUNOLOGY

Ranking the Susceptibility of Disulfide Bonds in Human IgG1 Antibodies by Reduction, Differential Alkylation, and LC−MS Analysis

(2010) Hongcheng Liu et al.   ANALYTICAL CHEMISTRY

Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?

(2010) Nigel Irwin et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mapping interactions of gastric inhibitory polypeptide with GIPR N-terminus using NMR and molecular dynamics simulations

(2010) Sonali H. Tikhele et al.   JOURNAL OF PEPTIDE SCIENCE

Therapeutic antibodies directed at G protein-coupled receptors

(2010) Catherine J. Hutchings et al.   mAbs

Characterization of antibody aggregation: Role of buried, unpaired cysteines in particle formation

(2009) Stephen R. Brych et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Exploring blocking assays using Octet, ProteOn, and Biacore biosensors

(2008) Yasmina N. Abdiche et al.   ANALYTICAL BIOCHEMISTRY

Dorothy Hodgkin Lecture 2008 Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesitydiabetes?

(2008) P. R. Flatt   DIABETIC MEDICINE