期刊
MICROSCOPY
卷 65, 期 4, 页码 341-352出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmicro/dfw014
关键词
antibody discovery; single B cell cloning; chicken monoclonal antibody; ion channel; GPCR; DR4 DR5
类别
资金
- Crystal Bioscience, Inc.
The analysis of secreted antibody from large and diverse populations of B cells in parallel at the clonal level can reveal desirable antibodies for diagnostic or therapeutic applications. By immobilizing B cells in microdroplets with particulate reporters, decoding and isolating them in a microscopy environment, we have recovered panels of antibodies with rare attributes to therapeutically relevant targets. The ability to screen up to 100 million cells in a single experiment can be fully leveraged by accessing primary B-cell populations from evolutionarily divergent species such as chickens.
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