Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

Evaluation of the long-term effects of gastric inhibitory polypeptide–ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice

(2012) Nigel Irwin et al.   BRITISH JOURNAL OF NUTRITION

Outstanding Scientific Achievement Award Lecture 2011: Defeating Diabesity: The Case for Personalized Combinatorial Therapies

(2012) M. H. Tschop et al.   DIABETES

In Vitro and In Vivo Antagonism of a G Protein-Coupled Receptor (S1P3) with a Novel Blocking Monoclonal Antibody

(2012) Greg L. Harris et al.   PLoS One

GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis

(2012) Su-Jin Kim et al.   PLoS One

Molecular basis for negative regulation of the glucagon receptor

(2012) C. M. Koth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: A comparative study with CHO produced materials

(2011) Liming Liu et al.   BIOLOGICALS

Biological and functional characteristics of a novel low-molecular weight antagonist of glucose-dependent insulinotropic polypeptide receptor, SKL-14959, in vitro and in vivo

(2011) T. Nakamura et al.   DIABETES OBESITY & METABOLISM

Transgenic Rescue of Adipocyte Glucose-dependent Insulinotropic Polypeptide Receptor Expression Restores High Fat Diet-induced Body Weight Gain

(2011) Randi Ugleholdt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors

(2011) Shiva Kumar et al.   PLoS One

Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor

(2010) Wei Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Unraveling the Science of Incretin Biology

(2009) Michael A. Nauck   European Journal of Internal Medicine

Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

(2009) William J. Finlay et al.   JOURNAL OF MOLECULAR BIOLOGY

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

(2008) Nigel Irwin et al.   BIOLOGICAL CHEMISTRY

Dorothy Hodgkin Lecture 2008 Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesitydiabetes?

(2008) P. R. Flatt   DIABETIC MEDICINE

Targeted Ablation of Glucose-dependent Insulinotropic Polypeptide-producing Cells in Transgenic Mice Reduces Obesity and Insulin Resistance Induced by a High Fat Diet

(2008) Matthew C. Althage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The incretin system and its role in type 2 diabetes mellitus

(2008) J HOLST et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Vaccination against GIP for the Treatment of Obesity

(2008) Alma Fulurija et al.   PLoS One

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

(2008) Augen A. Pioszak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens

(2008) C. Lloyd et al.   PROTEIN ENGINEERING DESIGN & SELECTION