Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells

(2013) Serge Ginzburg et al.   PROSTATE

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

(2012) Seong-Su Han et al.   LEUKEMIA RESEARCH

Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells

(2012) Elke Firat et al.   PLoS One

Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells

(2012) Konstantin V. Golovine et al.   PROSTATE

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction

(2011) Sebastian Alers et al.   Autophagy

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

(2011) C. T. Shearn et al.   BIOCHEMISTRY

Targeting Aberrant PI3K/Akt Activation by PI103 Restores Sensitivity to TRAIL-Induced Apoptosis in Neuroblastoma

(2011) D. Opel et al.   CLINICAL CANCER RESEARCH

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

(2011) Sei Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

(2011) C. T. Shearn et al.   MOLECULAR PHARMACOLOGY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines

(2011) Azhar R. Hussain et al.   PLoS One

Aberrant AKT activation drives well-differentiated liposarcoma

(2011) A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Autophagy in Cancer Development and Therapy

(2010) Ivan Dikic et al.   CANCER RESEARCH

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

(2010) Ming Li et al.   CELLULAR SIGNALLING

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis

(2010) Carmen Palacios et al.   LEUKEMIA RESEARCH

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Overexpression of the Zinc Uptake Transporter hZIP1 Inhibits Nuclear Factor- B and Reduces the Malignant Potential of Prostate Cancer Cells In vitro and In vivo

(2008) K. Golovine et al.   CLINICAL CANCER RESEARCH

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

(2008) Liping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

In vivogrowth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from thePiperspecies

(2007) Daniel P. Bezerra et al.   JOURNAL OF APPLIED TOXICOLOGY