Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

(2016) Michael B. Stout et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Strategies and Challenges in Clinical Trials Targeting Human Aging

(2016) John C. Newman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Translational Geroscience: Emphasizing function to achieve optimal longevity

(2016) Douglas R. Seals et al.   Aging-US

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

(2015) Douglas R. Seals et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index

(2015) Alice E. Kane et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy

(2015) D. Luo et al.   OSTEOPOROSIS INTERNATIONAL

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

The Course of Functional Impairment in Older Homeless Adults

(2015) Theora Cimino et al.   JAMA Internal Medicine

Effectiveness of Multicomponent Nonpharmacological Delirium Interventions

(2015) Tammy T. Hshieh et al.   JAMA Internal Medicine

La préhabilitation. Préparer les patients à la chirurgie pour améliorer la récupération fonctionnelle et réduire la morbidité postopératoire

(2014) C. Debes et al.   ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

White Matter and Cognitive Decline in Aging: A Focus on Processing Speed and Variability

(2014) Jonna Nilsson et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

(2014) Hanna K. Sanoff et al.   JNCI-Journal of the National Cancer Institute

A Physical Activity Intervention to Treat the Frailty Syndrome in Older Persons--Results From the LIFE-P Study

(2014) M. Cesari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Advances in Geroscience: Impact on Healthspan and Chronic Disease

(2014) J. B. Burch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric restriction and cancer: molecular mechanisms and clinical implications

(2014) Ophélie Meynet et al.   TRENDS IN MOLECULAR MEDICINE

Biologic aging, frailty, and age-related disease in chronic HIV infection

(2014) Thomas D. Brothers et al.   Current Opinion in HIV and AIDS

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle

(2013) Mark Romanick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

NIH Toolbox for Assessment of Neurological and Behavioral Function

(2013) R. C. Gershon et al.   NEUROLOGY

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Addressing the Aging Crisis in U.S. Criminal Justice Health Care

(2012) Brie A. Williams et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles

(2012) Jennifer A Hobin et al.   Journal of Translational Medicine

A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach

(2011) Helen C. Roberts et al.   AGE AND AGEING

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functional Impact of 10 Days of Bed Rest in Healthy Older Adults

(2011) P. Kortebein et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Translational research in oncology: key bottlenecks and new paradigms

(2010) Richard Simon   EXPERT REVIEWS IN MOLECULAR MEDICINE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE