Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord

(2016) Zhijuan Cao et al.   CLINICAL JOURNAL OF PAIN

Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

(2016) Yang Cai et al.   Journal of Neuroinflammation

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

(2015) Huei-Fen Jheng et al.   Disease Models & Mechanisms

TLR4-mediated IRAK1 activation induces TNF-α expression via JNK-dependent NF-κB activation in human bronchial epithelial cells

(2015) Sae Hoon Park et al.   European Journal of Inflammation

Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke

(2015) Nicholas Caffes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Opioid receptor trafficking and interaction in nociceptors

(2014) X Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling

(2014) Y. Han et al.   EUROPEAN JOURNAL OF PAIN

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-Like Receptor 4 Mutant and Null Mice Retain Morphine-Induced Tolerance, Hyperalgesia, and Physical Dependence

(2014) Theresa Alexandra Mattioli et al.   PLoS One

Blocking of the ATP sensitive potassium channel ameliorates the ischaemia-reperfusion injury in the rat testis

(2014) S. Shimizu et al.   Andrology

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

(2013) Stefania Merighi et al.   BIOCHEMICAL PHARMACOLOGY

Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells

(2013) Francisco J. Ortega et al.   GLIA

Blockade of Toll-Like Receptor 4 Attenuates Morphine Tolerance and Facilitates the Pain Relieving Properties of Morphine

(2013) L. N. Eidson et al.   JOURNAL OF NEUROSCIENCE

Persistent Peripheral Inflammation Attenuates Morphine-Induced Periaqueductal Gray Glial Cell Activation and Analgesic Tolerance in the Male Rat

(2013) Lori N. Eidson et al.   JOURNAL OF PAIN

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Expression of calcitonin gene-related peptide receptor subunits in cultured neurons following morphine treatment

(2013) Hailiang Yan et al.   NEUROSCIENCE LETTERS

Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage

(2013) Cigdem Tosun et al.   STROKE

Up-regulated ATP-sensitive potassium channels play a role in increased inflammation and plaque vulnerability in macrophages

(2012) Ming-Ying Ling et al.   ATHEROSCLEROSIS

Biochemical regulation of the inflammasome

(2012) Jennifer K. Dowling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Microglia: A Promising Target for Treating Neuropathic and Postoperative Pain, and Morphine Tolerance

(2011) Yeong-Ray Wen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration

(2010) Tobias Johansson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

(2010) Antonio De Maio   CELL STRESS & CHAPERONES

Involvement of Spinal Microglial P2X7 Receptor in Generation of Tolerance to Morphine Analgesia in Rats

(2010) D. Zhou et al.   JOURNAL OF NEUROSCIENCE

Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein90 pathway

(2010) A.S. Tay et al.   NEUROSCIENCE

Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

(2010) M.R. Hutchinson et al.   NEUROSCIENCE

Targeting microglial purinergic signaling to improve morphine analgesia

(2010) Ru-Rong Ji   PAIN

Morphine peripheral analgesia depends on activation of the PI3K /AKT/nNOS/NO/KATP signaling pathway

(2010) T. M. Cunha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice

(2010) Hiroko Tsutsui et al.   Gastroenterology Research and Practice

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

ATP-sensitive potassium channels: A promising target for protecting neurovascular unit function in stroke

(2009) Xiu-Lan Sun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cell-type specific activation of p38 and ERK mediates calcitonin gene-related peptide involvement in tolerance to morphine-induced analgesia

(2009) Zhiyong Wang et al.   FASEB JOURNAL

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

The Role of Mitogen-Activated Protein Kinase (MAPK) in Morphine Tolerance and Dependence

(2009) Yong Chen et al.   MOLECULAR NEUROBIOLOGY

The Inflammasomes

(2009) Mohamed Lamkanfi et al.   PLoS Pathogens

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation

(2008) Oscar M. Pello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA

Opening of microglial KATPchannels inhibits rotenone-induced neuroinflammation

(2008) Fang Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glibenclamide Reduces Inflammation, Vasogenic Edema, and Caspase-3 Activation after Subarachnoid Hemorrhage

(2008) J Marc Simard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF- 1

(2008) C. Happel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Delta opioid receptors mediate chemotaxis in bone marrow-derived dendritic cells

(2008) Alan Bénard et al.   JOURNAL OF NEUROIMMUNOLOGY

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Diazoxide Increases Liver and Kidney HSP25 and HSP70 After Shock and Stroke

(2008) Joseph C. O'Sullivan et al.   JOURNAL OF SURGICAL RESEARCH

A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

(2007) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity

(2007) Jie-Lin Pu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY