Nociception modulation by supraspinal group III metabotropic glutamate receptors

Intracellular mGluR5 plays a critical role in neuropathic pain

(2016) Kathleen Vincent et al.   Nature Communications

Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics

(2015) Adam G Walker et al.   CURRENT OPINION IN PHARMACOLOGY

Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond

(2014) Enza Palazzo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Selectivity and Evolutionary Divergence of Metabotropic Glutamate Receptors for Endogenous Ligands and G Proteins Coupled to Phospholipase C or TRP Channels

(2014) Hye Jin Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior

(2014) Christine E. Gee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

(2014) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions

(2013) Francesca Rossi et al.   JOURNAL OF NEUROPHYSIOLOGY

Effects of a Metabotropic Glutamate Receptor Subtype 7 Negative Allosteric Modulator in the Periaqueductal Grey on Pain Responses and Rostral Ventromedial Medulla Cell Activity in Rat

(2013) Enza Palazzo et al.   Molecular Pain

Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs

(2012) Peter J. Flor et al.   BIOCHEMICAL PHARMACOLOGY

Changes in Cannabinoid Receptor Subtype 1 Activity and Interaction with Metabotropic Glutamate Subtype 5 Receptors in the Periaqueductal Gray- Rostral Ventromedial Medulla Pathway in a Rodent Neuropathic Pain Model

(2012) Enza Palazzo et al.   CNS & Neurological Disorders-Drug Targets

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors

(2012) Matteo Bernabucci et al.   Molecular Pain

NAAG Peptidase Inhibition in the Periaqueductal Gray and Rostral Ventromedial Medulla Reduces Flinching in the Formalin Model of Inflammation

(2012) Toshihiko Yamada et al.   Molecular Pain

Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat

(2012) Livio Luongo et al.   NEUROPHARMACOLOGY

Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus

(2012) Marion S. Mercier et al.   NEUROPHARMACOLOGY

Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors

(2012) R.M. Govea et al.   NEUROSCIENCE

Metabotropic glutamate subtype 7 and 8 receptors oppositely modulate cardiac nociception in the rat nucleus tractus solitarius

(2012) X.H. Liu et al.   NEUROSCIENCE

Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins

(2012) Ralf Enz   Frontiers in Molecular Neuroscience

Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators

(2011) Douglas J. Sheffler et al.   ACS Chemical Neuroscience

Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep

(2011) Sharron Dolan et al.   BEHAVIOURAL PHARMACOLOGY

Transient receptor potential vanilloid type 1 and pain development

(2011) Enza Palazzo et al.   CURRENT OPINION IN PHARMACOLOGY

Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family

(2011) Joseph H. Neale et al.   JOURNAL OF NEUROCHEMISTRY

mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making

(2011) Hao Sun et al.   JOURNAL OF NEUROPHYSIOLOGY

Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABAA receptors

(2011) Guangchen Ji et al.   JOURNAL OF NEUROPHYSIOLOGY

Metabotropic Glutamate Receptor Subtype 8 in the Amygdala Modulates Thermal Threshold, Neurotransmitter Release, and Rostral Ventromedial Medulla Cell Activity in Inflammatory Pain

(2011) E. Palazzo et al.   JOURNAL OF NEUROSCIENCE

Group II/III Metabotropic Glutamate Receptors Exert Endogenous Activity-Dependent Modulation of TRPV1 Receptors on Peripheral Nociceptors

(2011) S. M. Carlton et al.   JOURNAL OF NEUROSCIENCE

The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?

(2011) S. J. Sukoff Rizzo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pain-Related Increase of Excitatory Transmission and Decrease of Inhibitory Transmission in the Central Nucleus of the Amygdala are Mediated by mGluR1

(2011) Wenjie Ren et al.   Molecular Pain

mGlu2 Metabotropic Glutamate Receptors Restrain Inflammatory Pain and Mediate the Analgesic Activity of Dual mGlu2/mGlu3 Receptor Agonists

(2011) Magda Zammataro et al.   Molecular Pain

Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain

(2011) Hua Wang et al.   NEUROREPORT

Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives

(2011) S. Urwyler   PHARMACOLOGICAL REVIEWS

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Acute pharmacological modulation of mGluR8 reduces measures of anxiety

(2010) Robert M. Duvoisin et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents

(2010) Hirohiko Hikichi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reactive Oxygen Species Are Involved in Group I mGluR-Mediated Facilitation of Nociceptive Processing in Amygdala Neurons

(2010) Guangchen Ji et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of Metabotropic Glutamate Receptor 5 in the Amygdala Modulates Pain-Like Behavior

(2010) B. J. Kolber et al.   JOURNAL OF NEUROSCIENCE

Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation

(2010) G. Ji et al.   JOURNAL OF NEUROSCIENCE

Functional Plasticity of Group II Metabotropic Glutamate Receptors in Regulating Spinal Excitatory and Inhibitory Synaptic Input in Neuropathic Pain

(2010) H.-Y. Zhou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat

(2009) Sharron Dolan et al.   BEHAVIOURAL PHARMACOLOGY

l-Serine-O-phosphate in the central nervous system

(2009) Jordan E. Antflick et al.   BRAIN RESEARCH

Differential Roles of Peripheral Metabotropic Glutamate Receptors in Bee Venom-Induced Nociception and Inflammation in Conscious Rats

(2009) Hui-Sheng Chen et al.   JOURNAL OF PAIN

Capsaicin-Induced Glutamate Release Is Implicated in Nociceptive Processing Through Activation of Ionotropic Glutamate Receptors and Group I Metabotropic Glutamate Receptor in Primary Afferent Fibers

(2009) You-Hong Jin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7

(2009) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Feed-forward inhibition as a buffer of the neuronal input-output relation

(2009) M. Ferrante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function

(2008) Susan M. Carlton et al.   BRAIN RESEARCH

Intracerebroventricular Administration of N-Acetylaspartylglutamate (NAAG) Peptidase Inhibitors is Analgesic in Inflammatory Pain

(2008) Tatsuo Yamamoto et al.   Molecular Pain

Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents

(2008) A. Pałucha-Poniewiera et al.   NEUROPHARMACOLOGY

Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors

(2008) Enza Palazzo et al.   NEUROPHARMACOLOGY

Intact Aδ-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats

(2008) G. Ji et al.   NEUROSCIENCE

Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain

(2008) H.-M. Zhang et al.   NEUROSCIENCE

Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparation☆

(2008) Ratan K. Banik et al.   PAIN

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain

(2007) Cyril Goudet et al.   PAIN