Article
Immunology
Xavier Mas-Orea, Lilian Basso, Catherine Blanpied, Claire Gaveriaux-Ruff, Nicolas Cenac, Gilles Dietrich
Summary: This study identifies the important role of the delta opioid receptor (DOR) in relieving intestinal inflammatory pain and suggests the potential of developing peripherally restricted DOR analgesics for intestinal disorders, which could avoid the side effects associated with drugs targeting the mu opioid receptor (MOR).
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Carlos Alberto Castillo, Inmaculada Ballesteros-Yanez, David Agustin Leon-Navarro, Jose Luis Albasanz, Mairena Martin
Summary: The amyloid beta peptide plays a central role in Alzheimer's disease pathology. Exposure to A beta(25-35) in rat cortical neurons increased mGluR density and affinity, along with up-regulation of adenosine A(1)R and A(2A)R. The study highlights the possible involvement of metabotropic glutamate and adenosine receptors in the early events of AD physiopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ekaterina V. Pershina, Irina Yu. Chernomorets, Dmitry A. Fedorov, Vladimir I. Arkhipov
Summary: In this study, the neuroprotective properties of the combination of memantine, a non-competitive NMDA receptor antagonist, and VU 0422288, a positive allosteric modulator of metabotropic glutamate receptors, were investigated. The results showed that the combined use of memantine and VU 0422288 significantly reduced neuronal cell death in the CA1 region of the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Vanessa Pereira, Juri Aparicio Arias, Amadeu Llebaria, Cyril Goudet
Summary: Neuropathic pain is a challenging condition to manage. In this study, the role of the amygdala in regulating neuropathic pain was investigated. The activation of mGlu4 receptors in the amygdala was found to alleviate sensory and depressive-like symptoms in a mouse model of neuropathy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
M. Carmen Ruiz-Cantero, Elsa Cortes-Montero, Aakanksha Jain, Angeles Montilla-Garcia, Inmaculada Bravo-Caparros, Jaehoon Shim, Pilar Sanchez-Blazquez, Clifford J. Woolf, Jose M. Baeyens, Enrique J. Cobos
Summary: The sigma-1 receptor interacts with TRPV1 and the μ-opioid receptor, and antagonizing sigma-1 receptor can reduce PGE2- and NGF-induced hyperalgesia by increasing the activity of the μ-opioid receptor. This mechanism is not effective against GDNF-induced hyperalgesia. The sigma-1 antagonism transfers the sigma-1 receptor from TRPV1 to μ-opioid receptor and harnesses endogenous opioids produced by TRPV1+ neurons to reduce hyperalgesia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniel H. Wolf, David Zheng, Christian Kohler, Bruce I. Turetsky, Kosha Ruparel, Theodore D. Satterthwaite, Mark A. Elliott, Mary E. March, Alan J. Cross, Mark A. Smith, Stephen R. Zukin, Ruben C. Gur, Raquel E. Gur
Summary: This study found individual differences in symptom reduction with the mGluR2 positive allosteric modulator AZD8529 in schizophrenia patients, as well as improved n-back fMRI activation. Despite no significant overall effects, drug versus placebo effects on brain region activation correlated with symptom reduction, suggesting broader effects across multiple symptom domains.
MOLECULAR PSYCHIATRY
(2022)
Review
Neurosciences
Ananth Prasad Burada, Rajesh Vinnakota, Bertrand Lambolez, Ludovic Tricoire, Janesh Kumar
Summary: Enigmatic orphan glutamate delta receptors (GluD) are a type of ionotropic glutamate receptors (iGluRs) that do not bind glutamate or evoke currents when binding glycine and D-serine. They are believed to function as structural proteins that facilitate synapse formation, maturation, and maintenance in the hippocampus and cerebellum. Recent research suggests that GluD receptors have interactions with metabotropic glutamate receptors (mGlus) and are gated by their activation, with new tools and structures helping to define their role in synaptic physiology.
Article
Reproductive Biology
Alexandra Spirkova, Veronika Kovarikova, Zuzana Sefcikova, Jozef Pisko, Martina Ksinanova, Juraj Koppel, Dusan Fabian, Stefan Cikos
Summary: The study reveals that glutamic acid can affect preimplantation embryo development through cell membrane receptors. High extracellular concentrations of glutamic acid can inhibit blastocyst development, which is of practical significance.
BIOLOGY OF REPRODUCTION
(2022)
Article
Neurosciences
G. Martella, P. Bonsi, P. Imbriani, G. Sciamanna, H. Nguyen, L. Yu-Taeger, M. Schneider, S. M. Poli, R. Lutjens, A. Pisani
Summary: Impairment of long-term synaptic plasticity is a unique endophenotype of certain forms of dystonia. Broad-spectrum antimuscarinic drugs and negative allosteric modulators of metabotropic glutamate receptor subtypes may be potential therapeutic options for dystonia treatment. The findings suggest common signaling pathway dysfunction among distinct dystonia genes and indicate the potential of dipraglurant as a novel therapeutic agent for this debilitating disorder.
Review
Pharmacology & Pharmacy
Ananth Prasad Burada, Rajesh Vinnakota, Pratibha Bharti, Priyanka Dutta, Neelima Dubey, Janesh Kumar
Summary: GluD receptors are a subfamily of ionotropic glutamate receptors that play a crucial role in synapse formation, maturation, and maintenance of central nervous system functions. Despite the lack of knowledge about their endogenous ligands, significant discoveries have been made regarding their role in mediating trans-synaptic interactions and their unique non-swapped architecture. Additionally, the prospect of GluD ionotropic activity being regulated by direct interaction with metabotropic glutamate receptors is exciting.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Jinyue Liu, Shilin Jia, Fang Huang, Hongwen He, Wenguo Fan
Summary: This study reviewed the mechanisms of peripheral glutamate-mediated orofacial pain, the regulation of glutamate in the periphery, and the translation of these findings into pain treatments.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Reuben Levy-Myers, Daniel Daudelin, Chan Hyun Na, Shanthini Sockanathan
Summary: This study demonstrates that the protein GDE3 regulates actin remodeling to release a unique subtype of extracellular vesicles (EVs) with distinct functions. GDE3 is expressed in astrocytes but not neurons and is responsible for releasing EVs containing annexin A1 and GDE3 via the protein WAVE3. Mice lacking GDE3 show decreased miniature excitatory postsynaptic current amplitudes in hippocampal neurons.
Article
Pharmacology & Pharmacy
Maria Morena, Andrei S. Nastase, Alessia Santori, Benjamin F. Cravatt, Rebecca M. Shansky, Matthew N. Hill
Summary: The endocannabinoid system has different effects on fear extinction in males and females, with increased AEA signaling impairing extinction in females, while inhibition of 2-AG hydrolysis promoting active fear responses. Sex- and brain region-specific changes were also observed in AEA and 2-AG levels after extinction training. These findings may have implications for sex-specific therapeutics in trauma-related disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Chaohong Li, Baosheng Zhao, Chenlu Zhao, Lu Huang, Yuzhen Liu
Summary: The study revealed the expression and physiological function of mGluR1 in the CB. Activation of mGluR1 inhibited the response of CB to hypoxia and prolonged the latency period of the response.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Bethany H. Dennis, Stuart A. Neale, Fiona E. N. LeBeau, Thomas E. Salt
Summary: Aberrant cortical oscillations in the beta and gamma range are associated with symptoms of schizophrenia and other psychiatric conditions. Activation of Group II mGlu receptors, and mGlu2 specifically, with orthosteric agonists reduced the power of both beta and gamma oscillations in ACC without a significant effect on oscillation peak frequencies.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)