标题
High-altitude adaptation in humans: from genomics to integrative physiology
作者
关键词
High-altitude adaptation, Chronic mountain sickness, Genomics, Polycythemic response, Cardiovascular response
出版物
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 95, Issue 12, Pages 1269-1282
出版商
Springer Nature
发表日期
2017-09-26
DOI
10.1007/s00109-017-1584-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Genetic signatures of high-altitude adaptation in Tibetans
- (2017) Jian Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cerebral Edema in Chronic Mountain Sickness: a New Finding
- (2017) Haihua Bao et al. Scientific Reports
- Interaction of CARD14, SENP1 and VEGFA polymorphisms on susceptibility to high altitude polycythemia in the Han Chinese population at the Qinghai–Tibetan Plateau
- (2016) Yu Chen et al. BLOOD CELLS MOLECULES AND DISEASES
- Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells
- (2016) Felix C. Giani et al. Cell Stem Cell
- Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment
- (2016) Francisco C. Villafuerte et al. HIGH ALTITUDE MEDICINE & BIOLOGY
- Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge’s disease
- (2016) Priti Azad et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia
- (2016) Jayasri Nanduri et al. JOURNAL OF PHYSIOLOGY-LONDON
- Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease
- (2016) Shizheng Wu et al. Molecular Medicine Reports
- Long-term genetic stability and a high-altitude East Asian origin for the peoples of the high valleys of the Himalayan arc
- (2016) Choongwon Jeong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impact of Oxygen Levels on Human Hematopoietic Stem and Progenitor Cell Expansion
- (2016) Abhilasha Tiwari et al. STEM CELLS AND DEVELOPMENT
- Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
- (2016) Peggy Prickaerts et al. Epigenetics & Chromatin
- Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
- (2016) Salminen Antero et al. Aging and Disease
- Tissue hypoxia during ischemic stroke: Adaptive clues from hypoxia-tolerant animal models
- (2015) Thomas I. Nathaniel et al. BRAIN RESEARCH BULLETIN
- Altitude Adaptation: A Glimpse Through Various Lenses
- (2015) Tatum S. Simonson HIGH ALTITUDE MEDICINE & BIOLOGY
- HMOX2Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans
- (2015) Deying Yang et al. HUMAN MUTATION
- A Novel Candidate Region for Genetic Adaptation to High Altitude in Andean Populations
- (2015) Guido Valverde et al. PLoS One
- Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice
- (2015) Tsering Stobdan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic selection by high altitude: Beware of experiments at ambient conditions
- (2015) Josef T. Prchal PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression
- (2015) Lan Shao et al. Nature Communications
- Widespread Signals of Convergent Adaptation to High Altitude in Asia and America
- (2014) Matthieu Foll et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review
- (2014) G. F. Gonzales et al. ANDROLOGIA
- 1-A680T Variant in GUCY1A3 as a Candidate Conferring Protection From Pulmonary Hypertension Among Kyrgyz Highlanders
- (2014) M. R. Wilkins et al. Circulation-Cardiovascular Genetics
- Novel genomic signals of recent selection in an Ethiopian population
- (2014) Fasil Tekola-Ayele et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Human high-altitude adaptation: forward genetics meets the HIF pathway
- (2014) Abigail W. Bigham et al. GENES & DEVELOPMENT
- Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau
- (2014) Guo-Dong Wang et al. Genome Biology and Evolution
- Multiple evidence strands suggest that there may be as few as 19 000 human protein-coding genes
- (2014) Iakes Ezkurdia et al. HUMAN MOLECULAR GENETICS
- Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing
- (2014) Daisheng Song et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates
- (2014) J. Larson et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth
- (2014) J. Ueda et al. MOLECULAR AND CELLULAR BIOLOGY
- Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases
- (2014) Lei Cao et al. MOLECULAR NEUROBIOLOGY
- Direct measurement of local oxygen concentration in the bone marrow of live animals
- (2014) Joel A. Spencer et al. NATURE
- A genetic mechanism for Tibetan high-altitude adaptation
- (2014) Felipe R Lorenzo et al. NATURE GENETICS
- Investigating human disease using stem cell models
- (2014) Jared L. Sterneckert et al. NATURE REVIEWS GENETICS
- The Genetic Basis of Chronic Mountain Sickness
- (2014) Roy Ronen et al. PHYSIOLOGY
- Shared and Unique Signals of High-Altitude Adaptation in Geographically Distinct Tibetan Populations
- (2014) Tana Wuren et al. PLoS One
- The Andean Adaptive Toolkit to Counteract High Altitude Maladaptation: Genome-Wide and Phenotypic Analysis of the Collas
- (2014) Christina A. Eichstaedt et al. PLoS One
- Paleoindian settlement of the high-altitude Peruvian Andes
- (2014) Kurt Rademaker et al. SCIENCE
- Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans
- (2014) Xiang-Hong Xu et al. Scientific Reports
- Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes
- (2014) Nitin Udpa et al. GENOME BIOLOGY
- Whole-Genome Sequencing Uncovers the Genetic Basis of Chronic Mountain Sickness in Andean Highlanders
- (2013) Dan Zhou et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
- (2013) Gregg L. Semenza Annual Review of Pathology-Mechanisms of Disease
- Pulmonary Hypertension and Chronic Mountain Sickness
- (2013) Robert Naeije et al. HIGH ALTITUDE MEDICINE & BIOLOGY
- Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes
- (2013) Clémence Merlen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Genetic Signatures Reveal High-Altitude Adaptation in a Set of Ethiopian Populations
- (2013) Emilia Huerta-Sánchez et al. MOLECULAR BIOLOGY AND EVOLUTION
- Identification of a Tibetan-Specific Mutation in the Hypoxic Gene EGLN1 and Its Contribution to High-Altitude Adaptation
- (2013) Kun Xiang et al. MOLECULAR BIOLOGY AND EVOLUTION
- Sirtuin Deacetylases as Therapeutic Targets in the Nervous System
- (2013) Brett Langley et al. Neurotherapeutics
- Long-Lasting Changes in DNA Methylation Following Short-Term Hypoxic Exposure in Primary Hippocampal Neuronal Cultures
- (2013) Iain Hartley et al. PLoS One
- Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma
- (2012) W. Cruz-Munoz et al. CANCER RESEARCH
- Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents
- (2012) Baktybek Kojonazarov et al. HIGH ALTITUDE MEDICINE & BIOLOGY
- Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease
- (2012) Lezanne Ooi et al. JOURNAL OF NEURAL TRANSMISSION
- A Preliminary Study of Copy Number Variation in Tibetans
- (2012) Yong-Biao Zhang et al. PLoS One
- Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
- (2012) J. Nanduri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans
- (2012) F. Ji et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
- (2012) W. Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Genetic Architecture of Adaptations to High Altitude in Ethiopia
- (2012) Gorka Alkorta-Aranburu et al. PLoS Genetics
- Genetic adaptation to high altitude in the Ethiopian highlands
- (2012) Laura B Scheinfeldt et al. GENOME BIOLOGY
- A methylation assay for the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences in voided urine
- (2011) Tahlita C.M. Zuiverloon et al. BJU INTERNATIONAL
- From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
- (2011) S. M. Hattangadi et al. BLOOD
- Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
- (2011) Toshio Suda et al. Cell Stem Cell
- Peopling the Tibetan Plateau: Insights from Archaeology
- (2011) Mark Aldenderfer HIGH ALTITUDE MEDICINE & BIOLOGY
- Polymorphisms of renin-angiotensin system genes as a risk factor for high-altitude pulmonary oedema
- (2011) Tsering Stobdan et al. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- On the Origin of Tibetans and Their Genetic Basis in Adapting High-Altitude Environments
- (2011) Binbin Wang et al. PLoS One
- Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera
- (2010) F. Perna et al. BLOOD
- Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
- (2010) Ahmed Mohyeldin et al. Cell Stem Cell
- The interdependence of endothelin-1 and calcium: a review
- (2010) Nathan R. Tykocki et al. CLINICAL SCIENCE
- SENP1 Induces Prostatic Intraepithelial Neoplasia through Multiple Mechanisms
- (2010) Tasneem Bawa-Khalfe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
- (2010) Luyang Yu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A Genome-Wide Search for Signals of High-Altitude Adaptation in Tibetans
- (2010) S. Xu et al. MOLECULAR BIOLOGY AND EVOLUTION
- Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas
- (2010) Y. Peng et al. MOLECULAR BIOLOGY AND EVOLUTION
- Vascular Endothelial Growth Factor: Much More than an Angiogenesis Factor
- (2010) Donald R. Senger MOLECULAR BIOLOGY OF THE CELL
- Physiological Adaptation of the Cardiovascular System to High Altitude
- (2010) Robert Naeije PROGRESS IN CARDIOVASCULAR DISEASES
- Genetic Evidence for High-Altitude Adaptation in Tibet
- (2010) T. S. Simonson et al. SCIENCE
- Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
- (2010) X. Yi et al. SCIENCE
- Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data
- (2010) Abigail Bigham et al. PLoS Genetics
- Developmental adaptation: Where we go from here
- (2009) A. Roberto Frisancho AMERICAN JOURNAL OF HUMAN BIOLOGY
- Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
- (2009) G. L. Semenza BLOOD
- Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease
- (2009) Ivan Dimitrijevic et al. BMC Cardiovascular Disorders
- Frequency Spectrum Neutrality Tests: One for All and All for One
- (2009) G. Achaz GENETICS
- Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau
- (2009) Mian Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hemoglobin research and the origins of molecular medicine
- (2008) A. N. Schechter BLOOD
- High Altitude Adaptation: Genetic Perspectives
- (2008) Tsering Stobdan et al. HIGH ALTITUDE MEDICINE & BIOLOGY
- Gene Expression in Chronic High Altitude Diseases
- (2008) Fabiola León-Velarde et al. HIGH ALTITUDE MEDICINE & BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now