Review
Biochemistry & Molecular Biology
Joerg Wilting, Juergen Becker
Summary: Despite the long history of research on the lymphatic vascular system, there is still much unknown about its structure, function, development, and evolution. The functions of lymphatic endothelial cells are more diverse than previously thought, with implications for various physiological processes.
CELL AND BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mechanics
Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das, Suman Chakraborty
Summary: This study presents a simulation mimicking tumor angiogenesis microenvironment on-chip, aiming to establish favorable conditions for gradients of vascular endothelial growth factor. The model platform explores different responses of endothelial cells in a micro-confined fluidic environment, showing potential significance for organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Article
Biotechnology & Applied Microbiology
Yumiko Yamada, Shih-Te Chuang, Ching-Yu Tseng, Guan-Ru Liao, Shin-Wu Liu, Yeu-Yang Tseng, Fong-Yuan Lin, Wei-Li Hsu
Summary: This study compared Taiwanese ORFV isolates and found that deletion mutants of VEGF and CBP genes both lost virulence in cell and goat models, with the VEGF-deletion mutant showing a greater loss of virulence.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Immunology
Haoting Zhan, Haolong Li, Chenxi Liu, Linlin Cheng, Songxin Yan, Yongzhe Li
Summary: Circulating VEGF levels are associated with autoimmune diseases and may predict disease manifestations and activity in patients, indicating potential therapeutic implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Biomaterials
Alena Maria Wolkersdorfer, Isabelle Jugovic, Lena Scheller, Marcus Gutmann, Lukas Hahn, Joachim Diessner, Tessa Luehmann, Lorenz Meinel
Summary: VEGF-A(165) positively affects hyperplasia, stenosis, and neovascularization, but its short half-life limits its potential therapeutic use. To address this issue, we designed VEGF-A(165) bioconjugates carrying PEG. After purification, two PEGylated species were obtained, with one or two PEG attached per VEGF-A(165) dimer. Both bioconjugates exhibited high purity, wild-type bioactivity, and increased hydrodynamic radii.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Environmental
Haoxiao Yan, Liulan Zhao, Qishuang He, Yifan Hu, Quanxi Li, Kuo He, Dongmei Zhang, Qiao Liu, Jie Luo, Wei Luo, Shiyi Chen, Lisen Li, Song Yang
Summary: In this study, the researchers investigated the effects of 4 weeks of intermittent hypoxic exposure (IHE) on liver angiogenesis and related regulatory mechanisms in largemouth bass. The findings revealed that IHE reduced the O2 tension for loss of equilibrium and increased the concentrations of red blood cells (RBC) and hemoglobin. The study also identified a correlation between increased angiogenesis and the expression of regulators such as Jagged, phosphoinositide-3-kinase (PI3K), and mitogen-activated protein kinase (MAPK). Additionally, the overexpression of factors related to angiogenesis processes mediated by HIF-independent pathways was associated with lactic acid (LA) accumulation in the liver.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)