Article
Biochemistry & Molecular Biology
Ehsan Rezabeigi, Gabriele Griffanti, Showan N. N. Nazhat
Summary: This study investigated the effect of pH on the gelation and biofabrication processes of collagen hydrogels. It was found that an increase in pH led to an increase in the stiffness of the hydrogels. Only hydrogels within a pH range of 6.5 to 10 could be used for biofabrication to form dense matrices.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Adam M. Leventhal, Danielle R. Madden, Natalia Peraza, Sara J. Schiff, Lucas Lebovitz, Lauren Whitted, Jessica Barrington-Trimis, Tyler B. Mason, Marissa K. Anderson, Alayna P. Tackett
Summary: In this randomized clinical trial, exposure to e-cigarettes with salt vs free-base nicotine formulations resulted in higher appeal, sweetness, and smoothness ratings, and lower bitterness and harshness ratings among adult nicotine or tobacco product users. The findings suggest that acid additives in e-cigarettes may enhance the sensory experience of vaping and should be considered in e-cigarette regulation.
Article
Biochemistry & Molecular Biology
Mahesh Koirala, H. B. Mihiri Shashikala, Jacob Jeffries, Bohua Wu, Stacie K. Loftus, Jonathan H. Zippin, Emil Alexov
Summary: The study investigates the pH-dependent stability of various melanosomal membrane proteins and their comparison to the stability of TYR, indicating a neutral pH optimum for TYR and contrasting pH optima for positive and negative pH regulators. The findings suggest a competitive mechanism among regulators resulting in pH equilibrium. Disease-causing variants were found to impact the pH dependence of melanosomal proteins, particularly OCA2 protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
David S. Yang, Arash Saeedi, Aram Davtyan, Mohsen Fathi, Michael B. Sherman, Mohammad S. Safari, Alena Klindziuk, Michelle C. Barton, Navin Varadarajan, Anatoly B. Kolomeisky, Peter G. Vekilov
Summary: The study found that p53 mutations can lead to the formation of unique protein clusters with important roles in fibril nucleation. By combining various techniques, the mechanisms of this phase transformation were illuminated, providing new insights into controlling protein fibrillization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Duncan W. S. MacKenzie, Anna Schaefer, Julia Steckner, Christopher A. Leo, Dalia Naser, Efrosini Artikis, Aron Broom, Travis Ko, Purnank Shah, Mikaela Q. Ney, Elisa Tran, Martin T. J. Smith, Brian Fuglestad, A. Joshua Wand, Charles L. Brooks, Elizabeth M. Meiering
Summary: Allostery is a fundamental process in protein regulation, but understanding the molecular mechanisms behind it is challenging. This study investigates the pH-dependent myristoyl switching in monomeric hisactophilin and reveals the atomistic details and coupling network involved using a combination of experimental measurements and molecular dynamics simulations. The study also demonstrates that small changes in core and surface hydrophobic residues can modulate the energetics of the myristoyl switch.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Chunjun Yan, Zheng Zhou
Summary: The study found that ellagic acid and pentagalloylglucose can effectively inhibit fibrillization of native human PrP, reduce the amount of fibrils produced, and lead to significant disaggregation of PrP fibrils. These natural polyphenols may have potential as prodrug molecules for the prevention and treatment of prion diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, General & Internal
Lone B. Enebo, Kasper K. Berthelsen, Martin Kankam, Michael T. Lund, Domenica M. Rubino, Altynai Satylganova, David C. W. Lau
Summary: The study aimed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the combination of Cagrilintide and Semaglutide for weight management. Results showed that concomitant treatment with Cagrilintide and Semaglutide was well tolerated with an acceptable safety profile. Larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination.
Article
Cell Biology
Margarita S. Komarova, Andrey R. Bukharev, Natalia N. Potapieva, Denis B. Tikhonov
Summary: In this study, the partial reversibility of ASIC1a's tachyphylaxis was demonstrated through long-term whole-cell recording of CHO cells transfected with rASIC1a cDNA, indicating that tachyphylaxis represents a slow desensitization of ASIC1a. Slow and steady-state desensitization were found to be independent processes, with certain drugs enhancing slow desensitization and others attenuating it. The effects of various conditions on ASIC1a response amplitude were correlated with the development of slow desensitization.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Engineering, Environmental
Yufan Chen, Christopher J. Miller, Richard N. Collins, T. David Waite
Summary: The study found that iron oxychloride (FeOCl) is a poor Fenton catalyst compared to ferrihydrite (Fhy) at different pH levels. Evaluation of the catalytic performance of FeOCl requires consideration of factors such as target contaminant adsorption and excessive use of H2O2.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Applied
Ling Zhou, Yingying Li, Yuxuan Lu, Shuangyin Wang, Yuqin Zou
Summary: In this study, the pH dependence of product selectivity in the electrocatalytic hydrogenation of furfural on Cu electrodes was systematically investigated. Under acidic conditions, a high proportion of the hydrogenolysis product was obtained, while under partial alkaline conditions, furfuryl alcohol was directly hydrogenated.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Engineering, Environmental
Yufan Chen, Christopher J. Miller, T. David Waite
Summary: The study reveals that both HO center dot and [(FeO)-O-IV](2+)/ Fe-III(O2H) are concurrently produced on the surface in the acidic to near-neutral pH range, but HO center dot is the major oxidant responsible for substrate oxidation. As pH increases, the yield of both oxidants is inhibited by the decreasing availability of surface sites due to ferrihydrite particle aggregation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lanlan Yu, Ruonan Wang, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen, Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu, Yanlian Yang, Chen Wang, Wenbo Zhang, Yuxing Yao, Xiaoguang Wang, Chenxuan Wang
Summary: Scanning tunneling microscopy (STM) is used to distinguish 18 coexisting conformational substates of the β-strand of hIAPP 8-37 and analyze the peptide-peptide interactions. This method also validates the existence of multiple conformations in other β-sheet peptide assemblies. The results provide insights into the conformational ensemble and interpeptide interactions in β-sheet peptide assembly.
ACS CENTRAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Yuechuan Xu, Kaitlin Knapp, Kyle N. Le, Nicholas P. Schafer, Mohammad S. Safari, Aram Davtyan, Peter G. Wolynes, Peter G. Vekilov
Summary: The research delves into the molecular pathways of amyloid fibrillization, revealing the presence of a complex at the fibril tip supported by nonnative contacts that hinder fibril growth. It also uncovers the dynamics of coupled structuring and assembly during fibril growth, which are more intricate than during the folding of most globular proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Materials Science, Multidisciplinary
Mingrui Pu, Xue Lai, Yan Li, Yulin Zhu, Zixiang Wei, Yiwu Zhu, Hui Chen, Leilei Tian, Feng He
Summary: Enhancing the aggregation ability of polymer solution can optimize the morphology and form an ideal nanoscale interpenetrating network structure, thus improving device performance.
ACS MATERIALS LETTERS
(2023)
Article
Environmental Sciences
Cailong Shen, Guangji Zhang, Kexin Li, Chao Yang
Summary: Arsenic in acid mine drainage (AMD) is commonly associated with the bioleaching of arsenic sulfide minerals. In this study, it was found that the bioleaching of iron-free orpiment can generate arsenic-containing AMD under iron deficient conditions, but can be inhibited when the initial pH is too low.
Article
Materials Science, Multidisciplinary
Subhasmita Panda, Kanti Kusum Yadav, Parth Sarthi Nayak, Manoranjan Arakha, Suman Jha
BULLETIN OF MATERIALS SCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Manoranjan Arakha, Sapna M. Borah, Mohammed Saleem, Anupam N. Jha, Suman Jha
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Spectroscopy
Lakkoji Satish, Shubhasmin Rana, Manoranjan Arakha, Lipeeka Rout, Basanti Ekka, Suman Jha, Priyabrat Dash, Harekrushna Sahoo
SPECTROSCOPY LETTERS
(2016)
Article
Chemistry, Multidisciplinary
Parth Sarthi Nayak, Manoranjan Arakha, Ajeet Kumar, Shreyasi Asthana, Bairagi C. Mallick, Suman Jha
Article
Biochemistry & Molecular Biology
Manoranjan Arakha, Jyoti Roy, Parth Sarthi Nayak, Bibekanand Mallick, Suman Jha
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Shreyasi Asthana, Bibekanand Mallick, Andrei T. Alexandrescu, Suman Jha
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2018)
Article
Biochemistry & Molecular Biology
Shreyasi Asthana, Mousumi Sahu, Parth Sarathi Nayak, Bibekanand Mallick, Suman Jha
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Chemistry, Multidisciplinary
Anuj Tiwari, Ashutosh Prince, Manoranjan Arakha, Suman Jha, Mohammed Saleem
Article
Engineering, Environmental
Parth Sarathi Nayak, Sapna M. Borah, Himanshu Gogoi, Shreyasi Asthana, Rakesh Bhatnagar, Anupam Nath Jha, Suman Jha
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Kanti Kusum Yadav, Monalisha Ojha, Ranit Pariary, Manoranjan Arakha, Anirban Bhunia, Suman Jha
Summary: The study explores the effects of surface potential and functional groups on the fibrillation of bovine insulin using zinc oxide nanoparticles. It is found that zinc oxide nanoparticles with positive surface potential enhance insulin fibrillation, but the addition of amino acids as surface functional groups mitigates this effect. The change in interfacial functional groups also reverses the interface-mediated destabilization of insulin conformation. The interaction between the amino acid functional groups and key amyloidogenic sequences of insulin is believed to stabilize the conformation and reduce fibrillation and cytotoxicity.
Article
Chemistry, Multidisciplinary
Banishree Sahoo, Lipsa Leena Panigrahi, Sonali Jena, Suman Jha, Manoranjan Arakha
Summary: This study investigates the role of oxidative stress generated at the interface of biosynthesized selenium nanoparticles (SeNPs) in defining antimicrobial and anti-biofilm activity. SeNPs with an average size of 119 nm were rapidly synthesized during the growth of Staphylococcus aureus using green chemistry principles. The antimicrobial study showed strong antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as anti-biofilm activity. The mechanism behind the antimicrobial activity of biosynthesized SeNPs was found to be the generation of reactive oxygen species (ROS) at the SeNPs interface, causing bacterial cell death through leakage of cytoplasmic contents.
Article
Chemistry, Multidisciplinary
Nibedita Behera, Manoranjan Arakha, Mamali Priyadarshinee, Biraja S. Pattanayak, Siba Soren, Suman Jha, Bairagi C. Mallick
Article
Chemistry, Physical
Ashutosh Prince, Anuj Tiwari, Pankaj Ror, Padmani Sandhu, Jyoti Roy, Suman Jha, Bibekanand Mallick, Yusuf Akhter, Mohammed Saleem
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Article
Chemistry, Multidisciplinary
Shreyasi Asthana, Sujit Kumar Bhutia, Harekrushna Sahoo, Suman Jha
JOURNAL OF CHEMICAL SCIENCES
(2017)
Article
Materials Science, Multidisciplinary
Kirti Kanta Sahoo, Manoranjan Arakha, Pradip Sarkar, Robin P. Davis, Suman Jha
INTERNATIONAL JOURNAL OF SMART AND NANO MATERIALS
(2016)