标题
Chimeric antigen receptor T cells: a novel therapy for solid tumors
作者
关键词
CAR-T cell, EGFR, HER2, Mesothelin, Solid tumors
出版物
Journal of Hematology & Oncology
Volume 10, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-03-29
DOI
10.1186/s13045-017-0444-9
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- New development in CAR-T cell therapy
- (2017) Zhenguang Wang et al. Journal of Hematology & Oncology
- Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma
- (2017) Kai-chao Feng et al. Journal of Hematology & Oncology
- Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies
- (2017) Jun Liu et al. Journal of Hematology & Oncology
- A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
- (2017) Erhao Zhang et al. Journal of Hematology & Oncology
- Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL
- (2016) X. Wang et al. BLOOD
- Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma
- (2016) Cheng Chen et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Bifunctional αHER2/CD3 RNA-engineered CART-like human T cells specifically eliminate HER2+ gastric cancer
- (2016) Feifei Luo et al. CELL RESEARCH
- Immune targets and neoantigens for cancer immunotherapy and precision medicine
- (2016) Rong-Fu Wang et al. CELL RESEARCH
- Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility
- (2016) Annette Künkele et al. CLINICAL CANCER RESEARCH
- Chimeric Antigen Receptor T Cell Therapy Targeting CD19-Positive Leukemia and Lymphoma in the Context of Stem Cell Transplantation
- (2016) Maria-Luisa Schubert et al. HUMAN GENE THERAPY
- Targeting of Tumor-Associated Glycoforms of MUC1 with CAR T Cells
- (2016) John Maher et al. IMMUNITY
- New Strategies for the Treatment of Solid Tumors with CAR-T Cells
- (2016) Hao Zhang et al. International Journal of Biological Sciences
- Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer
- (2016) Peter B. Alexander et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
- (2016) Leonid Cherkassky et al. JOURNAL OF CLINICAL INVESTIGATION
- Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
- (2016) Meenakshi Hegde et al. JOURNAL OF CLINICAL INVESTIGATION
- Mesothelin Immunotherapy for Cancer: Ready for Prime Time?
- (2016) Raffit Hassan et al. JOURNAL OF CLINICAL ONCOLOGY
- Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34+ cells of juvenile myelomonocytic leukemia
- (2016) Yozo Nakazawa et al. Journal of Hematology & Oncology
- Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia
- (2016) Bo Cai et al. Journal of Hematology & Oncology
- Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level
- (2016) De-Gang Song et al. Journal of Hematology & Oncology
- EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation
- (2016) Eskil Eskilsson et al. NEURO-ONCOLOGY
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects
- (2016) Shengmeng Di et al. Science China-Life Sciences
- Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells
- (2016) Fengtao You et al. Science China-Life Sciences
- Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
- (2016) Kaichao Feng et al. Science China-Life Sciences
- CD133, Selectively Targeting the Root of Cancer
- (2016) Jörg Schmohl et al. Toxins
- Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment
- (2016) Tetsuro Sasada et al. Frontiers in Pharmacology
- Toxicity and management in CAR T-cell therapy
- (2016) Challice L Bonifant et al. Molecular Therapy-Oncolytics
- Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies
- (2015) Xuequn Ren et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Bioactivity and Safety of IL13R 2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma
- (2015) C. E. Brown et al. CLINICAL CANCER RESEARCH
- Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
- (2015) Nabil Ahmed et al. JOURNAL OF CLINICAL ONCOLOGY
- A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer
- (2015) Mythili Koneru et al. Journal of Translational Medicine
- Enhancing Antitumor Efficacy of Chimeric Antigen Receptor T Cells Through Constitutive CD40L Expression
- (2015) Kevin J Curran et al. MOLECULAR THERAPY
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
- (2015) N. A. Rizvi et al. SCIENCE
- Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma
- (2015) Laura A. Johnson et al. Science Translational Medicine
- Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors
- (2015) A. Morello et al. Cancer Discovery
- CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells
- (2015) Alexander J. Davenport et al. Cancer Immunology Research
- Designing CAR T cells for glioblastoma
- (2015) Marcela V Maus OncoImmunology
- IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumorsin vivo
- (2015) Mythili Koneru et al. OncoImmunology
- Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFN
- (2014) A. Textor et al. CANCER RESEARCH
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Diverse Solid Tumors Expressing a Restricted Epitope of L1-CAM Can Be Targeted by Chimeric Antigen Receptor Redirected T Lymphocytes
- (2014) Hao Hong et al. JOURNAL OF IMMUNOTHERAPY
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma
- (2014) Hongsheng Miao et al. PLoS One
- Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
- (2014) P. S. Adusumilli et al. Science Translational Medicine
- Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor
- (2014) Agnes Shuk-Yee Lo et al. Molecular Therapy-Oncolytics
- T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: Towards tumor-directed oligoclonal T cell therapy
- (2013) Fatemeh Rahimi Jamnani et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Epidermal growth factor receptor targeting in cancer: A review of trends and strategies
- (2013) Chetan Yewale et al. BIOMATERIALS
- Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial
- (2013) Ryan D. Guest et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases
- (2013) M. J. Riese et al. CANCER RESEARCH
- Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-Free and Overall Survival in Early-Stage Lung Adenocarcinoma
- (2013) S. S. Kachala et al. CLINICAL CANCER RESEARCH
- Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
- (2013) Markus Chmielewski et al. IMMUNOLOGICAL REVIEWS
- Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor–Resistant Disease
- (2013) Kadoaki Ohashi et al. JOURNAL OF CLINICAL ONCOLOGY
- Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
- (2013) Petra C Schuberth et al. Journal of Translational Medicine
- Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma
- (2013) Meenakshi Hegde et al. MOLECULAR THERAPY
- The quest to overcome resistance to EGFR-targeted therapies in cancer
- (2013) Curtis R Chong et al. NATURE MEDICINE
- EGFRvIII Mediates Hepatocellular Carcinoma Cell Invasion by Promoting S100 Calcium Binding Protein A11 Expression
- (2013) Xiaoying Luo et al. PLoS One
- Advanced generation anti-prostate specific membrane antigen designer T Cells for prostate cancer immunotherapy
- (2013) Qiangzhong Ma et al. PROSTATE
- Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression
- (2013) R. Hassan et al. Science Translational Medicine
- Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
- (2013) G. L. Beatty et al. Cancer Immunology Research
- Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo
- (2013) E. Lanitis et al. Cancer Immunology Research
- T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
- (2013) M. V. Maus et al. Cancer Immunology Research
- Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
- (2012) H. J. Pegram et al. BLOOD
- Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)
- (2012) Ulf Petrausch et al. BMC CANCER
- Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma
- (2012) C. A. Del Vecchio et al. CANCER RESEARCH
- Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma
- (2012) Richard A. Morgan et al. HUMAN GENE THERAPY
- A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer
- (2012) Lana E Kandalaft et al. Journal of Translational Medicine
- Mesothelin-Targeted Agents in Clinical Trials and in Preclinical Development
- (2012) R. J. Kelly et al. MOLECULAR CANCER THERAPEUTICS
- Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
- (2012) Christopher C Kloss et al. NATURE BIOTECHNOLOGY
- HER-2/neu Gene Amplification in Esophageal Adenocarcinoma and Its Influence on Survival
- (2011) Sarah K. Thompson et al. ANNALS OF SURGICAL ONCOLOGY
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
- (2011) M. Chmielewski et al. CANCER RESEARCH
- In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)
- (2011) D.-G. Song et al. CANCER RESEARCH
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
- (2011) E. K. Moon et al. CLINICAL CANCER RESEARCH
- PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor
- (2011) Yozo Nakazawa et al. MOLECULAR THERAPY
- Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor
- (2011) Evripidis Lanitis et al. MOLECULAR THERAPY
- Cancer immunotherapy comes of age
- (2011) Ira Mellman et al. NATURE
- Immunology and immunotherapy of neuroblastoma
- (2011) Robert C. Seeger SEMINARS IN CANCER BIOLOGY
- Addition of GM-CSF to trastuzumab stabilises disease in trastuzumab-resistant HER2+ metastatic breast cancer patients
- (2010) Y C Cheng et al. BRITISH JOURNAL OF CANCER
- Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
- (2010) S. P. Kerkar et al. CANCER RESEARCH
- Phase I Clinical Trial of the Chimeric Anti-Mesothelin Monoclonal Antibody MORAb-009 in Patients with Mesothelin-Expressing Cancers
- (2010) R. Hassan et al. CLINICAL CANCER RESEARCH
- HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors
- (2010) N. Ahmed et al. CLINICAL CANCER RESEARCH
- Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer
- (2010) Marc Cartellieri et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- L1 is Highly Expressed in Tumors of the Nervous System: A Study of Over 8000 Human Tissues
- (2010) Tamina Rawnaq et al. JOURNAL OF SURGICAL RESEARCH
- High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
- (2009) W-F Cheng et al. BRITISH JOURNAL OF CANCER
- Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells
- (2009) E. Yvon et al. CLINICAL CANCER RESEARCH
- ErbB receptors and signaling pathways in cancer
- (2009) Nancy E Hynes et al. CURRENT OPINION IN CELL BIOLOGY
- A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity
- (2009) Y. Zhao et al. JOURNAL OF IMMUNOLOGY
- Immunotherapy for Osteosarcoma: Genetic Modification of T cells Overcomes Low Levels of Tumor Antigen Expression
- (2009) Nabil Ahmed et al. MOLECULAR THERAPY
- Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication
- (2009) Xiao-Song Zhong et al. MOLECULAR THERAPY
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
- (2009) C. Carpenito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Folate receptor alpha as a tumor target in epithelial ovarian cancer
- (2008) Kimberly R. Kalli et al. GYNECOLOGIC ONCOLOGY
- Tumor antigen precursor protein profiles of adult and pediatric brain tumors identify potential targets for immunotherapy
- (2008) Jian Gang Zhang et al. JOURNAL OF NEURO-ONCOLOGY
- Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
- (2008) M. Li et al. MOLECULAR CANCER THERAPEUTICS
- Mesothelin targeted cancer immunotherapy
- (2007) Raffit Hassan et al. EUROPEAN JOURNAL OF CANCER
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search