Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

(2016) David T. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-3 mediates bone marrow microenvironment-induced drug resistance in acute leukemia cells via Wnt/β-catenin signaling pathway

(2015) Kaimin Hu et al.   Journal of Hematology & Oncology

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Folate Receptor-α (FOLR1) Expression and Function in Triple Negative Tumors

(2015) Brian M. Necela et al.   PLoS One

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Farletuzumab in lung cancer

(2013) Anish Thomas et al.   LUNG CANCER

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo

(2013) E. Lanitis et al.   Cancer Immunology Research

Mesothelin, a novel immunotherapy target for triple negative breast cancer

(2012) Julia Tchou et al.   BREAST CANCER RESEARCH AND TREATMENT

Multicenter Trial of EC145 in Advanced, Folate-Receptor Positive Adenocarcinoma of the Lung

(2012) Martin J. Edelman et al.   Journal of Thoracic Oncology

Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical Outcome

(2012) Michelle K. Y. Siu et al.   PLoS One

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)

(2012) Jennifer D. Stone et al.   OncoImmunology

Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease

(2012) Daniel J O’Shannessy et al.   SpringerPlus

CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo

(2011) D.-G. Song et al.   BLOOD

In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)

(2011) D.-G. Song et al.   CANCER RESEARCH

Folate receptor α: A storied past and promising future in immunotherapy

(2011) Guy T. Clifton et al.   Human vaccines & immunotherapeutics

Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor

(2011) Evripidis Lanitis et al.   MOLECULAR THERAPY

Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor  , in Epithelial Ovarian Cancer: a Phase I Study

(2010) J. A. Konner et al.   CLINICAL CANCER RESEARCH

Folate-Targeted Therapies for Cancer

(2010) Wei Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor

(2008) Mariangela Figini et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY