Article
Multidisciplinary Sciences
Michael D. Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Kyoko Watanabe, Anthony Marketta, Michael Van Meter, Stefan Semrau, Julie Horowitz, Jing Tang, Jack A. Kosmicki, Veera M. Rajagopal, Yuxin Zou, Yariv Houvras, Arkopravo Ghosh, Christopher Gillies, Joelle Mbatchou, Ryan R. White, Niek Verweij, Jonas Bovijn, Neelroop N. Parikshak, Michelle G. LeBlanc, Marcus Jones, David J. Glass, Luca A. Lotta, Michael N. Cantor, Gurinder S. Atwal, Adam E. Locke, Manuel A. R. Ferreira, Raquel Deering, Charles Paulding, Alan R. Shuldiner, Gavin Thurston, Adolfo A. Ferrando, Will Salerno, Jeffrey G. Reid, John D. Overton, Jonathan Marchini, Hyun M. Kang, Aris Baras, Goncalo R. Abecasis, Eric Jorgenson
Summary: Clonal haematopoiesis, associated with ageing and adverse health outcomes, involves the expansion of certain blood cell lineages. This study identified novel germline genetic variations influencing predisposition to clonal haematopoiesis using exome sequence data from over 600,000 individuals. The study also found associations between clonal haematopoiesis and severe COVID-19 outcomes, cardiovascular disease, and malignancy.
Correction
Biochemistry & Molecular Biology
Jeong-Yub Kim, Hee-Jin Kim, Chan-Woong Jung, Byung-Il Choi, Dae-Hee Lee, Myung-Jin Park
Summary: A correction to this paper has been published.
Article
Oncology
Xiaomei Li, Min Lin, Juan Xu, Yu Pang, Hongzhi Chen, Peng Sun, Gang Hou
Summary: This article describes a case of invasive lobular carcinoma with solid and encapsulated papillary carcinoma growth pattern, which may present a diagnostic challenge, but the diagnosis was ultimately confirmed through immunohistochemistry and next-generation sequencing. Immunohistochemical analysis is crucial for differential diagnosis. The understanding of this newly discovered variant expands the morphological spectrum of invasive lobular carcinoma and helps to prevent misdiagnosis.
Article
Medicine, General & Internal
Michal Budzik, Maciej Sobieraj, Maria Sobol, Janusz Patera, Aleksandra Czerw, Andrzej Deptala, Anna Badowska-Kozakiewicz
Summary: Medullary breast cancer (MdBC) is a rare and highly malignant type of breast cancer. MdBC patients tend to be younger, have higher histological grade, larger tumor size, and less frequent lymph node involvement. Most MdBCs are triple-negative (not expressing estrogen receptor, progesterone receptor, and HER2 receptor), while IDCs are predominantly luminal (expressing estrogen receptor and/or progesterone receptor).
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Zhuo Wang, Yanjun Huang, Zhihua Zhou, Jian Huang, Yitong He, Pingming Qiu
Summary: This study finds that iron deficiency in the substantia nigra directly contributes to hyperlocomotion and sleep disturbances. By injecting the iron chelator deferiprone into the substantia nigra, researchers successfully reduced the iron content and observed behavioral changes. This study offers a promising direction for research and treatment of iron-related neuropsychiatric diseases.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Cell Biology
Yongguang Yang, Marissa Leonard, Zhenhua Luo, Syn Yeo, Gregory Bick, Mingang Hao, Chunmiao Cai, Mahmoud Charif, Jiang Wang, Jun-Lin Guan, Elyse E. Lower, Xiaoting Zhang
Summary: The study reveals the crucial role of MED1 in HER2-driven mammary tumorigenesis, showing that its overexpression can significantly promote the onset, growth, metastasis, and multiplicity of HER2 tumors. Further investigations demonstrate that MED1 is involved in epithelial-mesenchymal transition, cancer stem cell formation, and response to anti-HER2 therapy. Additionally, the research identifies Jab1 as the key target gene of MED1 contributing to these processes and shows a reciprocal regulation between Jab1 and MED1.
Article
Cell Biology
Tung-Wei Hsu, Hsin-An Chen, Po-Hsiang Liao, Yen-Hao Su, Ching-Feng Chiu, Chih-Yang Huang, Yu-Jung Lin, Chih-Chiang Hung, Ming-Hsin Yeh, Shian-Ying Sun, Chih-Ming Su
Summary: The study investigated the role of Dicer in regulating the migration, invasion, and stemness of breast cancer cells. The findings revealed that Dicer expression levels were associated with breast cancer risk, and inhibition of Dicer enhanced the migratory, invasive, and cancer stem cell properties of breast cancer cells.
Article
Cell Biology
Tung-Wei Hsu, Hsin-An Chen, Po-Hsiang Liao, Yen-Hao Su, Ching-Feng Chiu, Chih-Yang Huang, Yu-Jung Lin, Chih-Chiang Hung, Ming-Hsin Yeh, Shian-Ying Sung, Chih-Ming Su
Summary: The study revealed that Dicer plays a crucial role in regulating the migration, invasion, and stemness of breast cancer cells, and low levels of Dicer are associated with an increased risk of breast cancer.
Article
Multidisciplinary Sciences
Rashmi Rana, Vaishnavi Rathi, Kirti Chauhan, Kriti Jain, Satnam Singh Chhabra, Rajesh Acharya, Samir Kumar Kalra, Anshul Gupta, Sunila Jain, Nirmal Kumar Ganguly, Dharmendra Kumar Yadav
Summary: In meningiomas, the expression of EGFR vIII is significantly higher in benign tumors, with a high intensity observed in low-grade meningiomas, suggesting its oncogenic properties. Additionally, high Ki 67 values may serve as a predictive marker for patient survival and prognosis.
Article
Oncology
Vedita Bobde, Satish Helwatkar, Waman Raut
Summary: Synchronous or metachronous associations of multiple malignancies are commonly seen in syndromic cases. Double malignancies with thyroid carcinomas are more common with papillary thyroid carcinoma (PTC) than with other differentiated thyroid cancers. It is important to rule out the presence of double malignancy before treatment, as it may require different and multiple treatment modalities. We report a case of a columnar cell variant of PTC with invasive breast carcinoma in a 56-year-old female patient. The columnar cell variant of PTC is rare and exhibits inconspicuous classical nuclear features of conventional PTC.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Surgery
Fatima Z. Arif, Rebecca O. Breese, Kara Friend
Summary: This report describes a rare case of tall cell variant of invasive papillary breast carcinoma, with only 30 cases reported in the literature. The patient presented with bilateral breast masses on a screening mammogram and was lost to follow-up. After 4 years, she presented again with significant growth of the right breast mass and was diagnosed with triple negative invasive carcinoma of the tall cell papillary variant. She underwent surgical excision and chemotherapy.
Article
Medicine, General & Internal
Jiaqiang Zhang, Chang-Yun Lu, Ho-Min Chen, Szu-Yuan Wu
Summary: The study suggests that for patients with strongly HR-positive and ERBB2-negative IDC, NACT may be considered the first choice for neoadjuvant treatment.
Article
Biochemistry & Molecular Biology
Jeong-Yub Kim, Hee-Jin Kim, Chan-Woong Jung, Byung-Il Choi, Dae-Hee Lee, Myung-Jin Park
Summary: The study demonstrates that PARK7 plays a crucial role in maintaining stemness and therapeutic resistance in GSCs. Knockdown of PARK7 inhibits self-renewal and invasion abilities of GSCs, increases sensitivity to ionizing radiation, and suppresses the expression of GSC signatures. Overexpression of PARK7 in non-GSCs enhances self-renewal activities, migration, and IR resistance.
Article
Biochemistry & Molecular Biology
Yu-De Chu, Kwong-Ming Kee, Wey-Ran Lin, Ming-Wei Lai, Sheng-Nan Lu, Wen-Hung Chung, See-Tong Pang, Chau-Ting Yeh
Summary: The SYNE1-rs9479297 genotypes were found to be associated with the co-occurrence of HCC/TCC DPC and correlated with SYNE1 expression, which in turn impacted the proliferation and migration of HCC/TCC cells, thus affecting clinical outcomes.
Article
Oncology
Angeleke Saridakis, Elizabeth R. Berger, Malini Harigopal, Tristen Park, Nina Horowitz, Justin Le Blanc, Gregory Zanieski, Anees Chagpar, Rachel Greenup, Mehra Golshan, Donald R. Lannin
Summary: Invasive apocrine carcinomas have more aggressive features than non-apocrine carcinomas but the breast cancer-specific survival is the same. Half of these apocrine tumors are triple negative but these have more favorable features and much better survival than non-apocrine triple-negative cancers. The characteristics of apocrine carcinomas vary dramatically by molecular type, with triple-negative apocrine patients having better survival outcomes compared to non-apocrine triple-negative patients, while luminal apocrine patients have worse survival outcomes compared to non-apocrine luminal patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mu Zhou, Ann Leung, Sebastian Echegaray, Andrew Gentles, Joseph B. Shrager, Kristin C. Jensen, Gerald J. Berry, Sylvia K. Plevritis, Daniel L. Rubin, Sandy Napel, Olivier Gevaert
Article
Dermatology
Shyam S. Raghavan, Melissa Clark, Christine Y. Louie, Kristin C. Jensen, Brian Dietrich, Beth Michelle Beadle, Tarek El-Sawy, Fred Baik, Christian A. Kunder, Ryanne A. Brown
JOURNAL OF CUTANEOUS PATHOLOGY
(2020)
Article
Multidisciplinary Sciences
Jacob J. Chabon, Emily G. Hamilton, David M. Kurtz, Mohammad S. Esfahani, Everett J. Moding, Henning Stehr, Joseph Schroers-Martin, Barzin Y. Nabet, Binbin Chen, Aadel A. Chaudhuri, Chih Long Liu, Angela B. Hui, Michael C. Jin, Tej D. Azad, Diego Almanza, Young-Jun Jeon, Monica C. Nesselbush, Lyron Co Ting Keh, Rene F. Bonilla, Christopher H. Yoo, Ryan B. Ko, Emily L. Chen, David J. Merriott, Pierre P. Massion, Aaron S. Mansfield, Jin Jen, Hong Z. Ren, Steven H. Lin, Christina L. Costantino, Risa Burr, Robert Tibshirani, Sanjiv S. Gambhir, Gerald J. Berry, Kristin C. Jensen, Robert B. West, Joel W. Neal, Heather A. Wakelee, Billy W. Loo, Christian A. Kunder, Ann N. Leung, Natalie S. Lui, Mark F. Berry, Joseph B. Shrager, Viswam S. Nair, Daniel A. Haber, Lecia V. Sequist, Ash A. Alizadeh, Maximilian Diehn
Article
Genetics & Heredity
Alex H. Wagner, Brian Walsh, Georgia Mayfield, David Tamborero, Dmitriy Sonkin, Kilannin Krysiak, Jordi Deu-Pons, Ryan P. Duren, Jianjiong Gao, Julie McMurry, Sara Patterson, Catherine Fitz, Beth A. Pitel, Ozman U. Sezerman, Kyle Ellrott, Jeremy L. Warner, Damian T. Rieke, Tero Aittokallio, Ethan Cerami, Deborah I. Ritter, Lynn M. Schriml, Robert R. Freimuth, Melissa Haendel, Gordana Raca, Subha Madhavan, Michael Baudis, Jacques S. Beckmann, Rodrigo Dienstmann, Debyani Chakravarty, Xuan Shirley Li, Susan Mockus, Olivier Elemento, Nikolaus Schultz, Nuria Lopez-Bigas, Mark Lawler, Jeremy Goecks, Malachi Griffith, Obi L. Griffith, Adam A. Margolin
Article
Health Care Sciences & Services
Varun Suraj, Catherine Del Vecchio Fitz, Laura B. Kleiman, Suresh K. Bhavnani, Chinmay Jani, Surbhi Shah, Rana R. McKay, Jeremy Warner, Gil Alterovitz
Summary: This paper describes the creation of the SMART COVID Navigator, a clinical decision support tool designed to assist physicians in treating COVID-19 patients. The tool connects electronic health records with data from observational studies to predict the fatality and severity of COVID-19 progression based on a patient's medical conditions, allowing physicians to determine appropriate treatment strategies.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Mike T. Wei, Christine Y. Louie, Yu Chen, Jennifer Y. Pan, Susan Y. Quan, Robert Wong, Ryanne Brown, Melissa Clark, Kristin Jensen, Hubert Lau, Shai Friedland
Summary: This study compared the efficacy of cold snare polypectomy (CSP) and cold forceps polypectomy (CFP) in removing small colon polyps. The results showed that CFP was noninferior to CSP in achieving complete resection of nonpedunculated polyps <= 3 mm, with CFP requiring less time for the procedure. Therefore, CFP can be considered as an acceptable alternative for the removal of small colon polyps.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Barry M. Berger, Glenn J. Hanna, Marshall R. Posner, Eric M. Genden, Julio Lautersztain, Stephen P. Naber, Catherine Del Vecchio Fitz, Charlotte Kuperwasser
Summary: This study evaluated the clinical potential of circulating TTMV-HPV DNA testing in routine practice for patients with HPV-driven OPSCC. The findings suggest that TTMV-HPV DNA testing could be a valuable surveillance tool and may inform future strategies for HPV-driven malignancy surveillance.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Harry Klein, Tali Mazor, Ethan Siegel, Pavel Trukhanov, Andrea Ovalle, Catherine Del Vecchio Fitz, Zachary Zwiesler, Priti Kumari, Bernd Van Der Veen, Eric Marriott, Jason Hansel, Joyce Yu, Adem Albayrak, Susan Barry, Rachel B. Keller, Laura E. MacConaill, Neal Lindeman, Bruce E. Johnson, Barrett J. Rollins, Khanh T. Do, Brian Beardslee, Geoffrey Shapiro, Suzanne Hector-Barry, John Methot, Lynette Sholl, James Lindsay, Michael J. Hassett, Ethan Cerami
Summary: This article introduces an open-source platform called MatchMiner, which computationally matches genomically profiled cancer patients to precision medicine trials, accelerating the trial enrollment process. It provides data to demonstrate the impact of MatchMiner on trial consents.
NPJ PRECISION ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
T. Jessie Ge, Daniel Massana Roquero, Grace H. Holton, Kathleen E. Mach, Kris Prado, Hubert Lau, Kristin Jensen, Timothy C. Chang, Simon Conti, Kunj Sheth, Shan X. Wang, Joseph C. Liao
Summary: The researchers demonstrate a magnetic hydrogel that selectively coats kidney stone fragments for easy retrieval. The hydrogel shows good biocompatibility and antimicrobial activity, leading to improved stone clearance rates and patient outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Alicia Gunning, Sunil Kumar, Cassin Kimmel Williams, Barry M. Berger, Stephen P. Naber, Piyush B. Gupta, Catherine Del Vecchio Fitz, Charlotte Kuperwasser
Summary: The NavDx blood test is a reliable method for detecting and monitoring HPV-driven cancers by analyzing tumor tissue modified viral-HPV DNA. It has been clinically validated and integrated into clinical practice by over 1000 healthcare providers at over 400 medical sites in the US. The test is accredited by the College of American Pathologists and the New York State Department of Health and has demonstrated high sensitivity and specificity.
Article
Pathology
Cynthia K. Harris, Yigu Chen, Kristin C. Jensen, Jason L. Hornick, Claire Kilfoyle, Laura W. Lamps, Yael K. Heher
Summary: The United States and Canadian Academy of Pathology (USCAP) conducted a review of educational product outcomes data using high reliability organization (HRO) principles, identifying challenges and emerging fields in the education sector and providing data-driven decision support for future pathology education strategy.
ACADEMIC PATHOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Mike Wei, Christine Louie, Yu Chen, Jennifer Y. Pan, Susan Quan, Robert Wong, Ryanne Brown, Melissa Clark, Kristin C. Jensen, Hubert D. Lau, Shai Friedland
Article
Gastroenterology & Hepatology
Mike T. Wei, Christine Y. Louie, Yu Chen, Jennifer Y. Pan, Susan Y. Quan, Robert Wong, Ryanne Brown, Melissa Clark, Kristin Jensen, Hubert Lau, Shai Friedland
Summary: In this study, the use of EverLift (TM) in cold snare polypectomy for 4-9 mm non-pedunculated polyps was found to be non-inferior to the procedure without injection, with similar complete resection rates. However, injection of EverLift (TM) was associated with increased procedure time and frequency of hemostatic clip usage.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Mike T. Wei, Christine Louie, Yu Chen, Jennifer Y. Pan, Susan Y. Quan, Robert Wong, Ryanne Brown, Melissa Clark, Kristin Jensen, Hubert Lau, Shai Friedland
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Ilana B. Solomon, Sarah McGraw, Jenny Shen, Adem Albayrak, Gil Alterovitz, Melanie Davies, Catherine Del Vecchio Fitz, Rachel A. Freedman, Lisa N. Lopez, Lynette M. Sholl, Eliezer Van Allen, Joanne Mortimer, Marwan Fakih, Sumanta Pal, Karen L. Reckamp, Yuan Yuan, Stacy W. Gray
JCO PRECISION ONCOLOGY
(2020)